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Pharmacological inhibition of perforin dampens CD8+ T cell-mediated beta cell destruction in autoimmune diabetes in mice.

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Title: Pharmacological inhibition of perforin dampens CD8+ T cell-mediated beta cell destruction in autoimmune diabetes in mice.
Authors: Trivedi PM; St Vincent's Institute of Medical Research, Fitzroy, VIC, Australia. ptrivedi@svi.edu.au., Catterall T; St Vincent's Institute of Medical Research, Fitzroy, VIC, Australia., Sutton VR; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia., Moshovakis V; St Vincent's Institute of Medical Research, Fitzroy, VIC, Australia., Elkerbout L; St Vincent's Institute of Medical Research, Fitzroy, VIC, Australia., Akhlaghi H; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia., Spicer JA; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Boon L; JJP Biologics, Warsaw, Poland., Kay TWH; St Vincent's Institute of Medical Research, Fitzroy, VIC, Australia.; Department of Medicine, St Vincent's Hospital, The University of Melbourne, Fitzroy, VIC, Australia., Trapani JA; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. joe.trapani@petermac.org.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia. joe.trapani@petermac.org., Thomas HE; St Vincent's Institute of Medical Research, Fitzroy, VIC, Australia.; Department of Medicine, St Vincent's Hospital, The University of Melbourne, Fitzroy, VIC, Australia.
Source: Diabetologia [Diabetologia] 2026 Jun 11. Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
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  Data: Pharmacological inhibition of perforin dampens CD8<superscript>+</superscript> T cell-mediated beta cell destruction in autoimmune diabetes in mice.
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  Data: <searchLink fieldCode="AU" term="%22Trivedi+PM%22">Trivedi PM</searchLink>; St Vincent's Institute of Medical Research, Fitzroy, VIC, Australia. ptrivedi@svi.edu.au.<br /><searchLink fieldCode="AU" term="%22Catterall+T%22">Catterall T</searchLink>; St Vincent's Institute of Medical Research, Fitzroy, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Sutton+VR%22">Sutton VR</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Moshovakis+V%22">Moshovakis V</searchLink>; St Vincent's Institute of Medical Research, Fitzroy, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Elkerbout+L%22">Elkerbout L</searchLink>; St Vincent's Institute of Medical Research, Fitzroy, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Akhlaghi+H%22">Akhlaghi H</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Spicer+JA%22">Spicer JA</searchLink>; Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Boon+L%22">Boon L</searchLink>; JJP Biologics, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Kay+TWH%22">Kay TWH</searchLink>; St Vincent's Institute of Medical Research, Fitzroy, VIC, Australia.; Department of Medicine, St Vincent's Hospital, The University of Melbourne, Fitzroy, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Trapani+JA%22">Trapani JA</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. joe.trapani@petermac.org.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia. joe.trapani@petermac.org.<br /><searchLink fieldCode="AU" term="%22Thomas+HE%22">Thomas HE</searchLink>; St Vincent's Institute of Medical Research, Fitzroy, VIC, Australia.; Department of Medicine, St Vincent's Hospital, The University of Melbourne, Fitzroy, VIC, Australia.
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  Data: <searchLink fieldCode="JN" term="%220006777%22">Diabetologia</searchLink> [Diabetologia] 2026 Jun 11. <i>Date of Electronic Publication: </i>2026 Jun 11.
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              Text: 2026 Jun 11
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