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TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells.

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Title: TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells.
Authors: Wang Y; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Liang J; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; California Institute of Technology, Pasadena, CA, USA., Lange KS; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Demmerle J; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Liu EA; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Black E; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., He BJ; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Scripps Research Institute, San Diego, CA, USA., Ricketts CJ; Urologic Oncology Branch, National Cancer Institute, Bethesda, MD, USA., Yoshida SR; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Chong S; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA., Linehan WM; Urologic Oncology Branch, National Cancer Institute, Bethesda, MD, USA., Kavran JM; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Zang C; Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA.; University of Virginia Comprehensive Cancer Center, University of Virginia, Charlottesville, VA, USA., Cai D; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. danfeng.cai@jhu.edu.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, USA. danfeng.cai@jhu.edu.; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA. danfeng.cai@jhu.edu.
Source: Nature cell biology [Nat Cell Biol] 2026 Jul; Vol. 28 (7), pp. 1480-1495. Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
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  Data: TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells.
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  Data: <searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Liang+J%22">Liang J</searchLink>; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lange+KS%22">Lange KS</searchLink>; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Demmerle+J%22">Demmerle J</searchLink>; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Liu+EA%22">Liu EA</searchLink>; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Black+E%22">Black E</searchLink>; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22He+BJ%22">He BJ</searchLink>; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Scripps Research Institute, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ricketts+CJ%22">Ricketts CJ</searchLink>; Urologic Oncology Branch, National Cancer Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Yoshida+SR%22">Yoshida SR</searchLink>; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chong+S%22">Chong S</searchLink>; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Linehan+WM%22">Linehan WM</searchLink>; Urologic Oncology Branch, National Cancer Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kavran+JM%22">Kavran JM</searchLink>; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Zang+C%22">Zang C</searchLink>; Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA.; University of Virginia Comprehensive Cancer Center, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Cai+D%22">Cai D</searchLink>; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. danfeng.cai@jhu.edu.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, USA. danfeng.cai@jhu.edu.; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA. danfeng.cai@jhu.edu.
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