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Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis and Shock.

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Title: Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis and Shock.
Authors: Serpa Neto A; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care, Austin Hospital, Heidelberg, VIC, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Austin Hospital, Melbourne, VIC, Australia.; Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo., McNamara M; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., White K; School of Clinical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Australia.; Intensive Care Unit, Princess Alexandra Hospital, Woolloongabba, QLD, Australia., Cooper DJ; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care and Hyperbaric Medicine, Alfred Hospital, Melbourne, VIC, Australia., Fujii T; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care, Jikei University Hospital, Tokyo., Higgins AM; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., Hodgson CL; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Austin Hospital, Melbourne, VIC, Australia.; Department of Intensive Care and Hyperbaric Medicine, Alfred Hospital, Melbourne, VIC, Australia., Navarra L; Intensive Care Unit, Wellington Hospital, Wellington, New Zealand.; Medical Research Institute of New Zealand, Wellington., Nichol A; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care and Hyperbaric Medicine, Alfred Hospital, Melbourne, VIC, Australia.; Clinical Research Centre, University College Dublin Clinical Research Centre at St. Vincent's University Hospital, Dublin., Peake S; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care Medicine, Queen Elizabeth Hospital, Woodville South, SA, Australia.; Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia., Réa-Neto A; Department of Clinical Medicine, Universidade Federal do Parana, Curitiba, Brazil., Secombe P; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Intensive Care Unit, Alice Springs Hospital, Alice Springs, NT, Australia.; Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation, Prahran, VIC, Australia., Osborne F; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., Burrill H; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., See E; Department of Critical Care, Melbourne Medical School, University of Melbourne, Austin Hospital, Melbourne, VIC, Australia.; Department of Intensive Care, Royal Melbourne Hospital, Melbourne, VIC, Australia., Young M; Department of Intensive Care and Hyperbaric Medicine, Alfred Hospital, Melbourne, VIC, Australia., Zampieri FG; Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada., Plummer M; Department of Critical Care, Melbourne Medical School, University of Melbourne, Austin Hospital, Melbourne, VIC, Australia.; Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia.; Department of Intensive Care Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia., Christie C; Department of Intensive Care Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia., Nunnink L; Intensive Care Unit, Princess Alexandra Hospital, Woolloongabba, QLD, Australia.; Faculty of Medicine, Mayne Academy of Critical Care, University of Queensland, St. Lucia, Australia., Mackay J; Intensive Care Unit, Princess Alexandra Hospital, Woolloongabba, QLD, Australia., McGuinness S; Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital, Auckland, New Zealand., Marmol J; Intensive Care Unit, Wellington Hospital, Wellington, New Zealand., Tiruvoipati R; Department of Intensive Care Medicine, Frankston Hospital, Frankston, VIC, Australia.; Division of Medicine, Peninsula Clinical School, Monash University, Frankston, VIC, Australia.; Department of Intensive Care Medicine, Peninsula Private Hospital, Ramsay Health, Langwarrin, VIC, Australia., Bailey M; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation, Prahran, VIC, Australia., Young PJ; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Austin Hospital, Melbourne, VIC, Australia.; Intensive Care Unit, Wellington Hospital, Wellington, New Zealand.; Medical Research Institute of New Zealand, Wellington., Bellomo R; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care, Austin Hospital, Heidelberg, VIC, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Austin Hospital, Melbourne, VIC, Australia., Udy A; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care and Hyperbaric Medicine, Alfred Hospital, Melbourne, VIC, Australia.
Corporate Authors: SODa-BIC Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group
Source: The New England journal of medicine [N Engl J Med] 2026 Jun 12. Date of Electronic Publication: 2026 Jun 12.
Publication Type: Journal Article
Journal Info: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE
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  Data: Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis and Shock.
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  Data: <searchLink fieldCode="AU" term="%22Serpa+Neto+A%22">Serpa Neto A</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care, Austin Hospital, Heidelberg, VIC, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Austin Hospital, Melbourne, VIC, Australia.; Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo.<br /><searchLink fieldCode="AU" term="%22McNamara+M%22">McNamara M</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22White+K%22">White K</searchLink>; School of Clinical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Australia.; Intensive Care Unit, Princess Alexandra Hospital, Woolloongabba, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Cooper+DJ%22">Cooper DJ</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care and Hyperbaric Medicine, Alfred Hospital, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Fujii+T%22">Fujii T</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care, Jikei University Hospital, Tokyo.<br /><searchLink fieldCode="AU" term="%22Higgins+AM%22">Higgins AM</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hodgson+CL%22">Hodgson CL</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Austin Hospital, Melbourne, VIC, Australia.; Department of Intensive Care and Hyperbaric Medicine, Alfred Hospital, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Navarra+L%22">Navarra L</searchLink>; Intensive Care Unit, Wellington Hospital, Wellington, New Zealand.; Medical Research Institute of New Zealand, Wellington.<br /><searchLink fieldCode="AU" term="%22Nichol+A%22">Nichol A</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care and Hyperbaric Medicine, Alfred Hospital, Melbourne, VIC, Australia.; Clinical Research Centre, University College Dublin Clinical Research Centre at St. Vincent's University Hospital, Dublin.<br /><searchLink fieldCode="AU" term="%22Peake+S%22">Peake S</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care Medicine, Queen Elizabeth Hospital, Woodville South, SA, Australia.; Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Réa-Neto+A%22">Réa-Neto A</searchLink>; Department of Clinical Medicine, Universidade Federal do Parana, Curitiba, Brazil.<br /><searchLink fieldCode="AU" term="%22Secombe+P%22">Secombe P</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Intensive Care Unit, Alice Springs Hospital, Alice Springs, NT, Australia.; Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation, Prahran, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Osborne+F%22">Osborne F</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Burrill+H%22">Burrill H</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22See+E%22">See E</searchLink>; Department of Critical Care, Melbourne Medical School, University of Melbourne, Austin Hospital, Melbourne, VIC, Australia.; Department of Intensive Care, Royal Melbourne Hospital, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Young+M%22">Young M</searchLink>; Department of Intensive Care and Hyperbaric Medicine, Alfred Hospital, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Zampieri+FG%22">Zampieri FG</searchLink>; Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.<br /><searchLink fieldCode="AU" term="%22Plummer+M%22">Plummer M</searchLink>; Department of Critical Care, Melbourne Medical School, University of Melbourne, Austin Hospital, Melbourne, VIC, Australia.; Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia.; Department of Intensive Care Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Christie+C%22">Christie C</searchLink>; Department of Intensive Care Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Nunnink+L%22">Nunnink L</searchLink>; Intensive Care Unit, Princess Alexandra Hospital, Woolloongabba, QLD, Australia.; Faculty of Medicine, Mayne Academy of Critical Care, University of Queensland, St. Lucia, Australia.<br /><searchLink fieldCode="AU" term="%22Mackay+J%22">Mackay J</searchLink>; Intensive Care Unit, Princess Alexandra Hospital, Woolloongabba, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22McGuinness+S%22">McGuinness S</searchLink>; Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Marmol+J%22">Marmol J</searchLink>; Intensive Care Unit, Wellington Hospital, Wellington, New Zealand.<br /><searchLink fieldCode="AU" term="%22Tiruvoipati+R%22">Tiruvoipati R</searchLink>; Department of Intensive Care Medicine, Frankston Hospital, Frankston, VIC, Australia.; Division of Medicine, Peninsula Clinical School, Monash University, Frankston, VIC, Australia.; Department of Intensive Care Medicine, Peninsula Private Hospital, Ramsay Health, Langwarrin, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Bailey+M%22">Bailey M</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation, Prahran, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Young+PJ%22">Young PJ</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Austin Hospital, Melbourne, VIC, Australia.; Intensive Care Unit, Wellington Hospital, Wellington, New Zealand.; Medical Research Institute of New Zealand, Wellington.<br /><searchLink fieldCode="AU" term="%22Bellomo+R%22">Bellomo R</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care, Austin Hospital, Heidelberg, VIC, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Austin Hospital, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Udy+A%22">Udy A</searchLink>; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care and Hyperbaric Medicine, Alfred Hospital, Melbourne, VIC, Australia.
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