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Application of the 2024 McDonald Criteria in Individuals With Nonspecific Symptoms or Incidental Imaging Findings in a Multicenter Study.

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Title: Application of the 2024 McDonald Criteria in Individuals With Nonspecific Symptoms or Incidental Imaging Findings in a Multicenter Study.
Authors: Scharf A; Mellen Center for MS Treatment and Research, Cleveland Clinic, OH.; School of Medicine, Case Western Reserve University, Cleveland, OH., Cohen JA; Mellen Center for MS Treatment and Research, Cleveland Clinic, OH., Marrie RA; Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Canada., Miller AE; Corinne Goldsmith Dickinson Center for MS, Mount Sinai, New York, NY., Waubant E; UCSF MS and Neuroinflammation Center, University of California San Francisco., Kilbane M; Mellen Center for MS Treatment and Research, Cleveland Clinic, OH., Luskin E; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA., Azevedo CJ; Department of Neurology, University of Southern California, Los Angeles., Dever M; Mellen Center for MS Treatment and Research, Cleveland Clinic, OH., Alvarez E; UCHealth Neurosciences Center - Anschutz Medical Campus, University of Colorado, Aurora., Calabresi PA; Department of Neurology, Johns Hopkins University, Baltimore, MD., Chahin S; Department of Neurology, Barnes-Jewish Hospital, St. Louis, MO., Freeman L; Department of Neurology, Dell Medical School, University of Texas at Austin., Nakamura K; Department of Biomedical Engineering, Cleveland Clinic, OH., Longbrake EE; Yale University, New Haven, CT., Mowry EM; Department of Neurology, Johns Hopkins University, Baltimore, MD., Oh J; Division of Neurology, St. Michael's Hospital, Toronto, Canada., Rodrigues PR; QMENTA, Boston, MA., Ramos M; QMENTA, Boston, MA., Sotirchos ES; Department of Neurology, Johns Hopkins University, Baltimore, MD., Cutter GR; UAB School of Public Health, Birmingham, AL., Kaisey M; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA., Amin M; Mellen Center for MS Treatment and Research, Cleveland Clinic, OH., Toljan K; Mellen Center for MS Treatment and Research, Cleveland Clinic, OH., Illenberger N; Department of Population Health, NYU Langone Health, New York, NY., Bilello M; Department of Radiology, University of Pennsylvania, Philadelphia., Lee J; Imaging Institute, Cleveland Clinic, OH., Maya M; Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA., Obusez EC; Imaging Institute, Cleveland Clinic, OH., Schindler MK; Department of Neurology, University of Pennsylvania, Philadelphia., Suthiphosuwan S; Department of Medical Imaging, St. Michael's Hospital, Toronto, Canada., Ulano A; Department of Radiology, Larner College of Medicine at the University of Vermont, Burlington., Shinohara RT; Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia., Reich DS; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; and., Solomon AJ; Department of Neurological Sciences, Larner College of Medicine at the University of Vermont, Burlington., Sicotte NL; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA., Sati P; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA., Ontaneda D; Mellen Center for MS Treatment and Research, Cleveland Clinic, OH.
Source: Neurology [Neurology] 2026 Jul 14; Vol. 107 (1), pp. e218183. Date of Electronic Publication: 2026 Jun 12.
Publication Type: Journal Article; Multicenter Study; Observational Study
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-632X (Electronic) Linking ISSN: 00283878 NLM ISO Abbreviation: Neurology Subsets: MEDLINE
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  Data: Application of the 2024 McDonald Criteria in Individuals With Nonspecific Symptoms or Incidental Imaging Findings in a Multicenter Study.
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  Data: <searchLink fieldCode="AU" term="%22Scharf+A%22">Scharf A</searchLink>; Mellen Center for MS Treatment and Research, Cleveland Clinic, OH.; School of Medicine, Case Western Reserve University, Cleveland, OH.<br /><searchLink fieldCode="AU" term="%22Cohen+JA%22">Cohen JA</searchLink>; Mellen Center for MS Treatment and Research, Cleveland Clinic, OH.<br /><searchLink fieldCode="AU" term="%22Marrie+RA%22">Marrie RA</searchLink>; Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Canada.<br /><searchLink fieldCode="AU" term="%22Miller+AE%22">Miller AE</searchLink>; Corinne Goldsmith Dickinson Center for MS, Mount Sinai, New York, NY.<br /><searchLink fieldCode="AU" term="%22Waubant+E%22">Waubant E</searchLink>; UCSF MS and Neuroinflammation Center, University of California San Francisco.<br /><searchLink fieldCode="AU" term="%22Kilbane+M%22">Kilbane M</searchLink>; Mellen Center for MS Treatment and Research, Cleveland Clinic, OH.<br /><searchLink fieldCode="AU" term="%22Luskin+E%22">Luskin E</searchLink>; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Azevedo+CJ%22">Azevedo CJ</searchLink>; Department of Neurology, University of Southern California, Los Angeles.<br /><searchLink fieldCode="AU" term="%22Dever+M%22">Dever M</searchLink>; Mellen Center for MS Treatment and Research, Cleveland Clinic, OH.<br /><searchLink fieldCode="AU" term="%22Alvarez+E%22">Alvarez E</searchLink>; UCHealth Neurosciences Center - Anschutz Medical Campus, University of Colorado, Aurora.<br /><searchLink fieldCode="AU" term="%22Calabresi+PA%22">Calabresi PA</searchLink>; Department of Neurology, Johns Hopkins University, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Chahin+S%22">Chahin S</searchLink>; Department of Neurology, Barnes-Jewish Hospital, St. Louis, MO.<br /><searchLink fieldCode="AU" term="%22Freeman+L%22">Freeman L</searchLink>; Department of Neurology, Dell Medical School, University of Texas at Austin.<br /><searchLink fieldCode="AU" term="%22Nakamura+K%22">Nakamura K</searchLink>; Department of Biomedical Engineering, Cleveland Clinic, OH.<br /><searchLink fieldCode="AU" term="%22Longbrake+EE%22">Longbrake EE</searchLink>; Yale University, New Haven, CT.<br /><searchLink fieldCode="AU" term="%22Mowry+EM%22">Mowry EM</searchLink>; Department of Neurology, Johns Hopkins University, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Oh+J%22">Oh J</searchLink>; Division of Neurology, St. Michael's Hospital, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Rodrigues+PR%22">Rodrigues PR</searchLink>; QMENTA, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Ramos+M%22">Ramos M</searchLink>; QMENTA, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Sotirchos+ES%22">Sotirchos ES</searchLink>; Department of Neurology, Johns Hopkins University, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Cutter+GR%22">Cutter GR</searchLink>; UAB School of Public Health, Birmingham, AL.<br /><searchLink fieldCode="AU" term="%22Kaisey+M%22">Kaisey M</searchLink>; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Amin+M%22">Amin M</searchLink>; Mellen Center for MS Treatment and Research, Cleveland Clinic, OH.<br /><searchLink fieldCode="AU" term="%22Toljan+K%22">Toljan K</searchLink>; Mellen Center for MS Treatment and Research, Cleveland Clinic, OH.<br /><searchLink fieldCode="AU" term="%22Illenberger+N%22">Illenberger N</searchLink>; Department of Population Health, NYU Langone Health, New York, NY.<br /><searchLink fieldCode="AU" term="%22Bilello+M%22">Bilello M</searchLink>; Department of Radiology, University of Pennsylvania, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Imaging Institute, Cleveland Clinic, OH.<br /><searchLink fieldCode="AU" term="%22Maya+M%22">Maya M</searchLink>; Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Obusez+EC%22">Obusez EC</searchLink>; Imaging Institute, Cleveland Clinic, OH.<br /><searchLink fieldCode="AU" term="%22Schindler+MK%22">Schindler MK</searchLink>; Department of Neurology, University of Pennsylvania, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Suthiphosuwan+S%22">Suthiphosuwan S</searchLink>; Department of Medical Imaging, St. Michael's Hospital, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Ulano+A%22">Ulano A</searchLink>; Department of Radiology, Larner College of Medicine at the University of Vermont, Burlington.<br /><searchLink fieldCode="AU" term="%22Shinohara+RT%22">Shinohara RT</searchLink>; Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Reich+DS%22">Reich DS</searchLink>; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; and.<br /><searchLink fieldCode="AU" term="%22Solomon+AJ%22">Solomon AJ</searchLink>; Department of Neurological Sciences, Larner College of Medicine at the University of Vermont, Burlington.<br /><searchLink fieldCode="AU" term="%22Sicotte+NL%22">Sicotte NL</searchLink>; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Sati+P%22">Sati P</searchLink>; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Ontaneda+D%22">Ontaneda D</searchLink>; Mellen Center for MS Treatment and Research, Cleveland Clinic, OH.
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  Data: <searchLink fieldCode="JN" term="%220401060%22">Neurology</searchLink> [Neurology] 2026 Jul 14; Vol. 107 (1), pp. e218183. <i>Date of Electronic Publication: </i>2026 Jun 12.
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