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Predicting accumulation and age at onset of amyloid-β from genetic risk and resilience for Alzheimer's disease.

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Title: Predicting accumulation and age at onset of amyloid-β from genetic risk and resilience for Alzheimer's disease.
Authors: O'Brien EK; Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. Electronic address: e.obrien@ecu.edu.au., Cox T; Australian e-Health Research Centre, CSIRO, Parkville, Victoria, Australia., Fernandez S; Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia., Bourgeat P; Australian e-Health Research Centre, CSIRO, Herston, Queensland, Australia., Porter T; Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Curtin Medical School, Curtin University, Bentley, Western Australia, Australia., Goudey B; Australia BioCommons, The University of Melbourne, North Melbourne, Victoria, Australia; Florey Institute, The University of Melbourne, Parkville, Victoria, Australia., Doecke JD; Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia; Australian e-Health Research Centre, CSIRO, Herston, Queensland, Australia., Masters CL; Florey Institute, The University of Melbourne, Parkville, Victoria, Australia., Fripp J; Australian e-Health Research Centre, CSIRO, Herston, Queensland, Australia., Nho K; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA., Villemagne VL; Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Cruchaga C; Department of Psychiatry, Washington University, St. Louis, MO, 63110, USA; NeuroGenomics and Informatics, Washington University, St. Louis, MO, 63110, USA., Rowe CC; Florey Institute, The University of Melbourne, Parkville, Victoria, Australia; Department of Molecular Imaging & Therapy and Centre for PET, Austin Health, Heidelberg, Victoria, Australia., Saykin AJ; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA., Doré V; Australian e-Health Research Centre, CSIRO, Parkville, Victoria, Australia; Department of Molecular Imaging & Therapy and Centre for PET, Austin Health, Heidelberg, Victoria, Australia., Laws SM; Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Curtin Medical School, Curtin University, Bentley, Western Australia, Australia. Electronic address: s.laws@ecu.edu.au.
Source: EBioMedicine [EBioMedicine] 2026 Jul; Vol. 129, pp. 106329. Date of Electronic Publication: 2026 Jun 12.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Predicting accumulation and age at onset of amyloid-β from genetic risk and resilience for Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22O'Brien+EK%22">O'Brien EK</searchLink>; Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. Electronic address: e.obrien@ecu.edu.au.<br /><searchLink fieldCode="AU" term="%22Cox+T%22">Cox T</searchLink>; Australian e-Health Research Centre, CSIRO, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Fernandez+S%22">Fernandez S</searchLink>; Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Bourgeat+P%22">Bourgeat P</searchLink>; Australian e-Health Research Centre, CSIRO, Herston, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Porter+T%22">Porter T</searchLink>; Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Curtin Medical School, Curtin University, Bentley, Western Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Goudey+B%22">Goudey B</searchLink>; Australia BioCommons, The University of Melbourne, North Melbourne, Victoria, Australia; Florey Institute, The University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Doecke+JD%22">Doecke JD</searchLink>; Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia; Australian e-Health Research Centre, CSIRO, Herston, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Masters+CL%22">Masters CL</searchLink>; Florey Institute, The University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Fripp+J%22">Fripp J</searchLink>; Australian e-Health Research Centre, CSIRO, Herston, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Nho+K%22">Nho K</searchLink>; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Villemagne+VL%22">Villemagne VL</searchLink>; Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cruchaga+C%22">Cruchaga C</searchLink>; Department of Psychiatry, Washington University, St. Louis, MO, 63110, USA; NeuroGenomics and Informatics, Washington University, St. Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Rowe+CC%22">Rowe CC</searchLink>; Florey Institute, The University of Melbourne, Parkville, Victoria, Australia; Department of Molecular Imaging & Therapy and Centre for PET, Austin Health, Heidelberg, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Saykin+AJ%22">Saykin AJ</searchLink>; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Doré+V%22">Doré V</searchLink>; Australian e-Health Research Centre, CSIRO, Parkville, Victoria, Australia; Department of Molecular Imaging & Therapy and Centre for PET, Austin Health, Heidelberg, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Laws+SM%22">Laws SM</searchLink>; Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Curtin Medical School, Curtin University, Bentley, Western Australia, Australia. Electronic address: s.laws@ecu.edu.au.
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        Value: 10.1016/j.ebiom.2026.106329
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        Text: English
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              Text: 2026 Jul
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