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Analysis of monoclonal antibodies against the malaria invasion complex protein RIPR reveals the structural basis for synergistic antibody protection.

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Title: Analysis of monoclonal antibodies against the malaria invasion complex protein RIPR reveals the structural basis for synergistic antibody protection.
Authors: Williams BG; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK., Barrett JR; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK., Scott JB; Kymab Ltd., a Sanofi Company, Babraham Research Campus, Cambridge, UK., Rigby CA; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK., Cagiada M; Department of Statistics, University of Oxford, Oxford, UK; Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Quinkert D; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK., McHugh K; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK., Huhn A; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK., Burnap SA; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK., Gourjault C; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK., Byrne F; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK., Raghavan SSR; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Rodrigues A; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK., Bergamaschi L; Kymab Ltd., a Sanofi Company, Babraham Research Campus, Cambridge, UK., Balzarotti B; Kymab Ltd., a Sanofi Company, Babraham Research Campus, Cambridge, UK., Watson S; Kymab Ltd., a Sanofi Company, Babraham Research Campus, Cambridge, UK., Miller N; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK., King LDW; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK., Donnellan FR; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK., Gladstone CA; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK., Paterson J; Kymab Ltd., a Sanofi Company, Babraham Research Campus, Cambridge, UK., Scalabrino S; Kymab Ltd., a Sanofi Company, Babraham Research Campus, Cambridge, UK., Silk SE; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK., Salkeld J; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK., Minassian AM; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Skinner K; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK., Struwe WB; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK., Deane CM; Department of Statistics, University of Oxford, Oxford, UK., Reece ST; Kymab Ltd., a Sanofi Company, Babraham Research Campus, Cambridge, UK., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Draper SJ; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK. Electronic address: simon.draper@paediatrics.ox.ac.uk.
Source: Immunity [Immunity] 2026 Jun 12. Date of Electronic Publication: 2026 Jun 12.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
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  Data: Analysis of monoclonal antibodies against the malaria invasion complex protein RIPR reveals the structural basis for synergistic antibody protection.
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  Data: <searchLink fieldCode="AU" term="%22Williams+BG%22">Williams BG</searchLink>; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Barrett+JR%22">Barrett JR</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Scott+JB%22">Scott JB</searchLink>; Kymab Ltd., a Sanofi Company, Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Rigby+CA%22">Rigby CA</searchLink>; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Cagiada+M%22">Cagiada M</searchLink>; Department of Statistics, University of Oxford, Oxford, UK; Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Quinkert+D%22">Quinkert D</searchLink>; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22McHugh+K%22">McHugh K</searchLink>; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Huhn+A%22">Huhn A</searchLink>; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Burnap+SA%22">Burnap SA</searchLink>; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Gourjault+C%22">Gourjault C</searchLink>; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Byrne+F%22">Byrne F</searchLink>; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Raghavan+SSR%22">Raghavan SSR</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rodrigues+A%22">Rodrigues A</searchLink>; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bergamaschi+L%22">Bergamaschi L</searchLink>; Kymab Ltd., a Sanofi Company, Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Balzarotti+B%22">Balzarotti B</searchLink>; Kymab Ltd., a Sanofi Company, Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Watson+S%22">Watson S</searchLink>; Kymab Ltd., a Sanofi Company, Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Miller+N%22">Miller N</searchLink>; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22King+LDW%22">King LDW</searchLink>; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Donnellan+FR%22">Donnellan FR</searchLink>; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Gladstone+CA%22">Gladstone CA</searchLink>; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Paterson+J%22">Paterson J</searchLink>; Kymab Ltd., a Sanofi Company, Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Scalabrino+S%22">Scalabrino S</searchLink>; Kymab Ltd., a Sanofi Company, Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Silk+SE%22">Silk SE</searchLink>; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Salkeld+J%22">Salkeld J</searchLink>; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Minassian+AM%22">Minassian AM</searchLink>; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Skinner+K%22">Skinner K</searchLink>; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Struwe+WB%22">Struwe WB</searchLink>; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Deane+CM%22">Deane CM</searchLink>; Department of Statistics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Reece+ST%22">Reece ST</searchLink>; Kymab Ltd., a Sanofi Company, Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Ward+AB%22">Ward AB</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Draper+SJ%22">Draper SJ</searchLink>; Department of Paediatrics, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK. 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