Polyethylene glycol-maleimide amphiphilic carboxymethyl-hexanoyl chitosan enables cadherin-11-targeted hyaluronan synthase 2 delivery and hyaluronan biosynthesis in osteoarthritis.

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Title: Polyethylene glycol-maleimide amphiphilic carboxymethyl-hexanoyl chitosan enables cadherin-11-targeted hyaluronan synthase 2 delivery and hyaluronan biosynthesis in osteoarthritis.
Authors: Chen YJ; Department of Biomedical Engineering, I-Shou University, Kaohsiung City, 82445, Taiwan. Electronic address: ygchen2021@gmail.com., Tsai JH; Department of Biomedical Engineering, I-Shou University, Kaohsiung City, 82445, Taiwan. Electronic address: harelove0423@gmail.com., Hu JL; Department of Biomedical Engineering, I-Shou University, Kaohsiung City, 82445, Taiwan. Electronic address: alanhu0812@gmail.com., Wu CH; Department of Biomedical Engineering, I-Shou University, Kaohsiung City, 82445, Taiwan. Electronic address: azx11223456@gmail.com., Yang SW; Department of Orthopedics, Kaohsiung Veterans General Hospital, Kaohsiung City, 81341, Taiwan. Electronic address: swyang3028@gmail.com., Chen SY; Department of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu City, 30010, Taiwan; Graduate Institute of Biomedical Science, China Medical University, Taichung City, 40604, Taiwan; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung City, 80708, Taiwan. Electronic address: sanyuanchen@nycu.edu.tw., Chang SJ; Department of Biomedical Engineering, I-Shou University, Kaohsiung City, 82445, Taiwan. Electronic address: sjchang@isu.edu.tw.
Source: Carbohydrate polymers [Carbohydr Polym] 2026 Sep 01; Vol. 387, pp. 125472. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8307156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1344 (Electronic) Linking ISSN: 01448617 NLM ISO Abbreviation: Carbohydr Polym Subsets: MEDLINE
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  Data: Polyethylene glycol-maleimide amphiphilic carboxymethyl-hexanoyl chitosan enables cadherin-11-targeted hyaluronan synthase 2 delivery and hyaluronan biosynthesis in osteoarthritis.
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  Data: <searchLink fieldCode="AU" term="%22Chen+YJ%22">Chen YJ</searchLink>; Department of Biomedical Engineering, I-Shou University, Kaohsiung City, 82445, Taiwan. Electronic address: ygchen2021@gmail.com.<br /><searchLink fieldCode="AU" term="%22Tsai+JH%22">Tsai JH</searchLink>; Department of Biomedical Engineering, I-Shou University, Kaohsiung City, 82445, Taiwan. Electronic address: harelove0423@gmail.com.<br /><searchLink fieldCode="AU" term="%22Hu+JL%22">Hu JL</searchLink>; Department of Biomedical Engineering, I-Shou University, Kaohsiung City, 82445, Taiwan. Electronic address: alanhu0812@gmail.com.<br /><searchLink fieldCode="AU" term="%22Wu+CH%22">Wu CH</searchLink>; Department of Biomedical Engineering, I-Shou University, Kaohsiung City, 82445, Taiwan. Electronic address: azx11223456@gmail.com.<br /><searchLink fieldCode="AU" term="%22Yang+SW%22">Yang SW</searchLink>; Department of Orthopedics, Kaohsiung Veterans General Hospital, Kaohsiung City, 81341, Taiwan. Electronic address: swyang3028@gmail.com.<br /><searchLink fieldCode="AU" term="%22Chen+SY%22">Chen SY</searchLink>; Department of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu City, 30010, Taiwan; Graduate Institute of Biomedical Science, China Medical University, Taichung City, 40604, Taiwan; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung City, 80708, Taiwan. Electronic address: sanyuanchen@nycu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chang+SJ%22">Chang SJ</searchLink>; Department of Biomedical Engineering, I-Shou University, Kaohsiung City, 82445, Taiwan. Electronic address: sjchang@isu.edu.tw.
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              Text: 2026 Sep 01
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