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Influence of protein aggregates, extracellular vesicles, and lipoprotein fusion on ionizable lipid nanoparticles protein corona analysis.

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Title: Influence of protein aggregates, extracellular vesicles, and lipoprotein fusion on ionizable lipid nanoparticles protein corona analysis.
Authors: Borhan B; Department of Chemistry, Michigan State University, East Lansing, MI, 48824, USA. babak@chemistry.msu.edu., Murray AM; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA., Saei AA; Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, 171 77, Sweden., Ghaffari B; Department of Chemistry, Michigan State University, East Lansing, MI, 48824, USA., Jackson JE; Department of Chemistry, Michigan State University, East Lansing, MI, 48824, USA., Mohammed N; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA., Mitchell MJ; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Vali H; Department of Anatomy and Cell Biology, McGill University, Montreal, QC, H3A 0C7, Canada.; Facility for Electron Microscopy Research, McGill University, Montreal, QC, H3A 0C7, Canada., Whitehead KA; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA. kawhite@andrew.cmu.edu.; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA. kawhite@andrew.cmu.edu., Mahmoudi M; Precision Health Program, Michigan State University, East Lansing, MI, 48823, USA. mahmou22@msu.edu.; Department of Radiology, College of Human Medicine, Michigan State University, East Lansing, MI, 48823, USA. mahmou22@msu.edu.
Source: Nature communications [Nat Commun] 2026 Jun 12; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 12.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Borhan+B%22">Borhan B</searchLink>; Department of Chemistry, Michigan State University, East Lansing, MI, 48824, USA. babak@chemistry.msu.edu.<br /><searchLink fieldCode="AU" term="%22Murray+AM%22">Murray AM</searchLink>; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Saei+AA%22">Saei AA</searchLink>; Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, 171 77, Sweden.<br /><searchLink fieldCode="AU" term="%22Ghaffari+B%22">Ghaffari B</searchLink>; Department of Chemistry, Michigan State University, East Lansing, MI, 48824, USA.<br /><searchLink fieldCode="AU" term="%22Jackson+JE%22">Jackson JE</searchLink>; Department of Chemistry, Michigan State University, East Lansing, MI, 48824, USA.<br /><searchLink fieldCode="AU" term="%22Mohammed+N%22">Mohammed N</searchLink>; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mitchell+MJ%22">Mitchell MJ</searchLink>; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Vali+H%22">Vali H</searchLink>; Department of Anatomy and Cell Biology, McGill University, Montreal, QC, H3A 0C7, Canada.; Facility for Electron Microscopy Research, McGill University, Montreal, QC, H3A 0C7, Canada.<br /><searchLink fieldCode="AU" term="%22Whitehead+KA%22">Whitehead KA</searchLink>; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA. kawhite@andrew.cmu.edu.; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA. kawhite@andrew.cmu.edu.<br /><searchLink fieldCode="AU" term="%22Mahmoudi+M%22">Mahmoudi M</searchLink>; Precision Health Program, Michigan State University, East Lansing, MI, 48823, USA. mahmou22@msu.edu.; Department of Radiology, College of Human Medicine, Michigan State University, East Lansing, MI, 48823, USA. mahmou22@msu.edu.
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