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Recurrent COPA mutation drives R-spondin-independent Wnt activation in intestinal tumors.

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Title: Recurrent COPA mutation drives R-spondin-independent Wnt activation in intestinal tumors.
Authors: Fujii M; Department of Integrated Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan., Abeto N; Department of Pathology, Keio University School of Medicine, Tokyo, Japan.; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.; Course of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Tokyo, Japan., Kishimoto S; Department of Integrated Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan., Shiraishi K; Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.; Department of Clinical Genomics, National Cancer Center Research Institute, Tokyo, Japan., Hashimoto T; Department of Pathology, Keio University School of Medicine, Tokyo, Japan.; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.; Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan., Hiraoka N; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.; Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan., Nonaka S; Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan., Kojima M; Division of Pathology, Research Center for Innovative Oncology, National Cancer Center, Chiba, Japan.; Department of Surgical Pathology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Matano M; Department of Integrated Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan., Takahashi S; Department of Integrated Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan., Colozza G; Unit of Cell and Developmental Biology, Department of Biology, University of Pisa, Pisa, Italy., Koo BK; Center for Genome Engineering, Institute for Basic Science, Daejeon, Republic of Korea.; Graduate School of Stem Cell & Regenerative Biology, KAIST, Daejeon, Republic of Korea.; Department of Life Science, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea., Yatabe Y; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.; Course of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Tokyo, Japan.; Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan., Kato M; Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Tokyo, Japan., Sato T; Department of Integrated Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan. t.sato@keio.jp.; Human Biology Microbiome Quantum Research Center (Bio2Q), Keio University, Tokyo, Japan. t.sato@keio.jp., Sekine S; Department of Pathology, Keio University School of Medicine, Tokyo, Japan. shsekine@keio.jp.; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan. shsekine@keio.jp.; Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan. shsekine@keio.jp.
Source: Nature genetics [Nat Genet] 2026 Jun; Vol. 58 (6), pp. 1341-1352. Date of Electronic Publication: 2026 Jun 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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  Data: Recurrent COPA mutation drives R-spondin-independent Wnt activation in intestinal tumors.
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  Data: <searchLink fieldCode="AU" term="%22Fujii+M%22">Fujii M</searchLink>; Department of Integrated Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Abeto+N%22">Abeto N</searchLink>; Department of Pathology, Keio University School of Medicine, Tokyo, Japan.; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.; Course of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kishimoto+S%22">Kishimoto S</searchLink>; Department of Integrated Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Shiraishi+K%22">Shiraishi K</searchLink>; Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.; Department of Clinical Genomics, National Cancer Center Research Institute, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hashimoto+T%22">Hashimoto T</searchLink>; Department of Pathology, Keio University School of Medicine, Tokyo, Japan.; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.; Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hiraoka+N%22">Hiraoka N</searchLink>; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.; Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nonaka+S%22">Nonaka S</searchLink>; Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kojima+M%22">Kojima M</searchLink>; Division of Pathology, Research Center for Innovative Oncology, National Cancer Center, Chiba, Japan.; Department of Surgical Pathology, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Matano+M%22">Matano M</searchLink>; Department of Integrated Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+S%22">Takahashi S</searchLink>; Department of Integrated Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Colozza+G%22">Colozza G</searchLink>; Unit of Cell and Developmental Biology, Department of Biology, University of Pisa, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Koo+BK%22">Koo BK</searchLink>; Center for Genome Engineering, Institute for Basic Science, Daejeon, Republic of Korea.; Graduate School of Stem Cell & Regenerative Biology, KAIST, Daejeon, Republic of Korea.; Department of Life Science, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yatabe+Y%22">Yatabe Y</searchLink>; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.; Course of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Tokyo, Japan.; Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kato+M%22">Kato M</searchLink>; Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+T%22">Sato T</searchLink>; Department of Integrated Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan. t.sato@keio.jp.; Human Biology Microbiome Quantum Research Center (Bio2Q), Keio University, Tokyo, Japan. t.sato@keio.jp.<br /><searchLink fieldCode="AU" term="%22Sekine+S%22">Sekine S</searchLink>; Department of Pathology, Keio University School of Medicine, Tokyo, Japan. shsekine@keio.jp.; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan. shsekine@keio.jp.; Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan. shsekine@keio.jp.
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2026 Jun; Vol. 58 (6), pp. 1341-1352. <i>Date of Electronic Publication: </i>2026 Jun 12.
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