Recurrent COPA mutation drives R-spondin-independent Wnt activation in intestinal tumors.
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| Title: | Recurrent COPA mutation drives R-spondin-independent Wnt activation in intestinal tumors. |
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| Authors: | Fujii M; Department of Integrated Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan., Abeto N; Department of Pathology, Keio University School of Medicine, Tokyo, Japan.; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.; Course of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Tokyo, Japan., Kishimoto S; Department of Integrated Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan., Shiraishi K; Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.; Department of Clinical Genomics, National Cancer Center Research Institute, Tokyo, Japan., Hashimoto T; Department of Pathology, Keio University School of Medicine, Tokyo, Japan.; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.; Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan., Hiraoka N; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.; Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan., Nonaka S; Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan., Kojima M; Division of Pathology, Research Center for Innovative Oncology, National Cancer Center, Chiba, Japan.; Department of Surgical Pathology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Matano M; Department of Integrated Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan., Takahashi S; Department of Integrated Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan., Colozza G; Unit of Cell and Developmental Biology, Department of Biology, University of Pisa, Pisa, Italy., Koo BK; Center for Genome Engineering, Institute for Basic Science, Daejeon, Republic of Korea.; Graduate School of Stem Cell & Regenerative Biology, KAIST, Daejeon, Republic of Korea.; Department of Life Science, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea., Yatabe Y; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.; Course of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Tokyo, Japan.; Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan., Kato M; Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Tokyo, Japan., Sato T; Department of Integrated Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan. t.sato@keio.jp.; Human Biology Microbiome Quantum Research Center (Bio2Q), Keio University, Tokyo, Japan. t.sato@keio.jp., Sekine S; Department of Pathology, Keio University School of Medicine, Tokyo, Japan. shsekine@keio.jp.; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan. shsekine@keio.jp.; Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan. shsekine@keio.jp. |
| Source: | Nature genetics [Nat Genet] 2026 Jun; Vol. 58 (6), pp. 1341-1352. Date of Electronic Publication: 2026 Jun 12. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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