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ActiTect: a generalizable machine learning pipeline for REM sleep behavior disorder screening through standardized actigraphy.

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Title: ActiTect: a generalizable machine learning pipeline for REM sleep behavior disorder screening through standardized actigraphy.
Authors: Bertram D; Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany. dbertram@uni-koeln.de.; Institute for Biomedical Informatics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. dbertram@uni-koeln.de.; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. dbertram@uni-koeln.de., Ophey A; Medical Psychology | Neuropsychology and Gender Studies, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Cognitive Neuroscience, Insitute for Neuroscience and Medicine, INM-3, Research Center Juelich, Juelich, Germany., Röttgen S; Cognitive Neuroscience, Insitute for Neuroscience and Medicine, INM-3, Research Center Juelich, Juelich, Germany.; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Kufer K; Center of Neurology, Department of Parkinson, Sleep and Movement Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Merten N; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Fink GR; Cognitive Neuroscience, Insitute for Neuroscience and Medicine, INM-3, Research Center Juelich, Juelich, Germany.; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Kalbe E; Medical Psychology | Neuropsychology and Gender Studies, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Hansen C; Department of Neurology, University Medical Center Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany., Maetzler W; Department of Neurology, University Medical Center Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany., Kapsecker M; Department of Informatics, Technical University of Munich, Munich, Germany.; Institute for Digital Medicine, University Hospital Bonn, Bonn, Germany., Reimer LM; Institute for Digital Medicine, University Hospital Bonn, Bonn, Germany., Jonas S; Institute for Digital Medicine, University Hospital Bonn, Bonn, Germany., Damgaard AT; Lundbeck Foundation Parkinson's Disease Research Center (PACE), Aarhus University, Aarhus, Denmark.; Department of Electrical and Computer Engineering, Aarhus University, Aarhus, Denmark., Bertelsen NB; Lundbeck Foundation Parkinson's Disease Research Center (PACE), Aarhus University, Aarhus, Denmark., Skjaerbaek C; Lundbeck Foundation Parkinson's Disease Research Center (PACE), Aarhus University, Aarhus, Denmark., Borghammer P; Lundbeck Foundation Parkinson's Disease Research Center (PACE), Aarhus University, Aarhus, Denmark.; Department of Nuclear Medicine, Aarhus University Hospital, Aarhus, Denmark., Groenewald K; Oxford Parkinson's Disease Centre and Division of Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Ratti PL; Oxford Parkinson's Disease Centre and Division of Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Hu MT; Oxford Parkinson's Disease Centre and Division of Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Moreau N; Institute for Biomedical Informatics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Sommerauer M; Cognitive Neuroscience, Insitute for Neuroscience and Medicine, INM-3, Research Center Juelich, Juelich, Germany. michael.sommerauer@ukbonn.de.; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. michael.sommerauer@ukbonn.de.; Center of Neurology, Department of Parkinson, Sleep and Movement Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany. michael.sommerauer@ukbonn.de.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. michael.sommerauer@ukbonn.de., Bozek K; Institute for Biomedical Informatics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. k.bozek@uni-koeln.de.; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. k.bozek@uni-koeln.de.; Cluster of Excellence for Aging and Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. k.bozek@uni-koeln.de.
Source: NPJ digital medicine [NPJ Digit Med] 2026 Jun 13. Date of Electronic Publication: 2026 Jun 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101731738 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2398-6352 (Electronic) Linking ISSN: 23986352 NLM ISO Abbreviation: NPJ Digit Med
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  Data: <searchLink fieldCode="AU" term="%22Bertram+D%22">Bertram D</searchLink>; Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany. dbertram@uni-koeln.de.; Institute for Biomedical Informatics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. dbertram@uni-koeln.de.; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. dbertram@uni-koeln.de.<br /><searchLink fieldCode="AU" term="%22Ophey+A%22">Ophey A</searchLink>; Medical Psychology | Neuropsychology and Gender Studies, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Cognitive Neuroscience, Insitute for Neuroscience and Medicine, INM-3, Research Center Juelich, Juelich, Germany.<br /><searchLink fieldCode="AU" term="%22Röttgen+S%22">Röttgen S</searchLink>; Cognitive Neuroscience, Insitute for Neuroscience and Medicine, INM-3, Research Center Juelich, Juelich, Germany.; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Kufer+K%22">Kufer K</searchLink>; Center of Neurology, Department of Parkinson, Sleep and Movement Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Merten+N%22">Merten N</searchLink>; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Fink+GR%22">Fink GR</searchLink>; Cognitive Neuroscience, Insitute for Neuroscience and Medicine, INM-3, Research Center Juelich, Juelich, Germany.; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Kalbe+E%22">Kalbe E</searchLink>; Medical Psychology | Neuropsychology and Gender Studies, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Hansen+C%22">Hansen C</searchLink>; Department of Neurology, University Medical Center Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Maetzler+W%22">Maetzler W</searchLink>; Department of Neurology, University Medical Center Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Kapsecker+M%22">Kapsecker M</searchLink>; Department of Informatics, Technical University of Munich, Munich, Germany.; Institute for Digital Medicine, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Reimer+LM%22">Reimer LM</searchLink>; Institute for Digital Medicine, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Jonas+S%22">Jonas S</searchLink>; Institute for Digital Medicine, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Damgaard+AT%22">Damgaard AT</searchLink>; Lundbeck Foundation Parkinson's Disease Research Center (PACE), Aarhus University, Aarhus, Denmark.; Department of Electrical and Computer Engineering, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Bertelsen+NB%22">Bertelsen NB</searchLink>; Lundbeck Foundation Parkinson's Disease Research Center (PACE), Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Skjaerbaek+C%22">Skjaerbaek C</searchLink>; Lundbeck Foundation Parkinson's Disease Research Center (PACE), Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Borghammer+P%22">Borghammer P</searchLink>; Lundbeck Foundation Parkinson's Disease Research Center (PACE), Aarhus University, Aarhus, Denmark.; Department of Nuclear Medicine, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Groenewald+K%22">Groenewald K</searchLink>; Oxford Parkinson's Disease Centre and Division of Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ratti+PL%22">Ratti PL</searchLink>; Oxford Parkinson's Disease Centre and Division of Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hu+MT%22">Hu MT</searchLink>; Oxford Parkinson's Disease Centre and Division of Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Moreau+N%22">Moreau N</searchLink>; Institute for Biomedical Informatics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Sommerauer+M%22">Sommerauer M</searchLink>; Cognitive Neuroscience, Insitute for Neuroscience and Medicine, INM-3, Research Center Juelich, Juelich, Germany. michael.sommerauer@ukbonn.de.; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. michael.sommerauer@ukbonn.de.; Center of Neurology, Department of Parkinson, Sleep and Movement Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany. michael.sommerauer@ukbonn.de.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. michael.sommerauer@ukbonn.de.<br /><searchLink fieldCode="AU" term="%22Bozek+K%22">Bozek K</searchLink>; Institute for Biomedical Informatics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. k.bozek@uni-koeln.de.; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. k.bozek@uni-koeln.de.; Cluster of Excellence for Aging and Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. k.bozek@uni-koeln.de.
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