E-cigarette aerosols induce the hydrolysis of lysosomal glycerophospholipids through PLA2G4A activation initiated by nicotine binding to CHRNA3/α3 nAChR in airway epithelial cells.

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Title: E-cigarette aerosols induce the hydrolysis of lysosomal glycerophospholipids through PLA2G4A activation initiated by nicotine binding to CHRNA3/α3 nAChR in airway epithelial cells.
Authors: Yu Y; Key Lab of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, China.; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China., Xu S; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.; State Key Lab of Reproductive Medicine and Offspring Health, Institute of Toxicology, Nanjing Medical University, Nanjing, China., Yang L; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China., Shu S; Key Lab of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, China., Zhou H; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China., Hua Z; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China., Wang L; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China., Zhu Y; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.; Department of Cadre Respiratory, The Affiliated Jinling Hospital of Nanjing Medical University, Nanjing, China., Shi A; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China., Xia R; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Chen C; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China., Wang SL; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.; State Key Lab of Reproductive Medicine and Offspring Health, Institute of Toxicology, Nanjing Medical University, Nanjing, China.
Source: Autophagy [Autophagy] 2026 Jun 21, pp. 1-25. Date of Electronic Publication: 2026 Jun 21.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265188 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8635 (Electronic) Linking ISSN: 15548627 NLM ISO Abbreviation: Autophagy Subsets: MEDLINE
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  Data: E-cigarette aerosols induce the hydrolysis of lysosomal glycerophospholipids through PLA2G4A activation initiated by nicotine binding to CHRNA3/α3 nAChR in airway epithelial cells.
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  Data: <searchLink fieldCode="AU" term="%22Yu+Y%22">Yu Y</searchLink>; Key Lab of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, China.; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Xu+S%22">Xu S</searchLink>; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.; State Key Lab of Reproductive Medicine and Offspring Health, Institute of Toxicology, Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Shu+S%22">Shu S</searchLink>; Key Lab of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zhou+H%22">Zhou H</searchLink>; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Hua+Z%22">Hua Z</searchLink>; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.; Department of Cadre Respiratory, The Affiliated Jinling Hospital of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Shi+A%22">Shi A</searchLink>; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Xia+R%22">Xia R</searchLink>; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Wang+SL%22">Wang SL</searchLink>; Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.; State Key Lab of Reproductive Medicine and Offspring Health, Institute of Toxicology, Nanjing Medical University, Nanjing, China.
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              Text: 2026 Jun 21
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