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Acidic bile salts induce APE1-dependent PRDX2 activation to drive oxaliplatin resistance via ferroptosis inhibition.

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Title: Acidic bile salts induce APE1-dependent PRDX2 activation to drive oxaliplatin resistance via ferroptosis inhibition.
Authors: Chen L; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA., Ballout F; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA., Chen Z; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA., Thangaretnam K; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA., Que J; Division of Digestive and Liver Diseases and Center for Human Development, Department of Medicine, Columbia University, New York, NY, USA., Chen XS; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA., McDonald OG; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA; Department of Pathology, Miller School of Medicine, University of Miami, Miami, FL, USA., Zaika A; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA., Livingstone A; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA., Giordano S; Department of Oncology, University of Torino and Candiolo Cancer Institute, Candiolo, Italy., Shiekhattar R; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA; Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA., Lu H; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. Electronic address: heng.lu@med.miami.edu., Peng D; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. Electronic address: dxp737@miami.edu., El-Rifai W; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA; Department of Veterans Affairs, Miami Healthcare System, Miami, FL, USA. Electronic address: wxe45@miami.edu.
Source: Redox biology [Redox Biol] 2026 Sep; Vol. 95, pp. 104254. Date of Electronic Publication: 2026 Jun 09.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
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  Data: Acidic bile salts induce APE1-dependent PRDX2 activation to drive oxaliplatin resistance via ferroptosis inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Ballout+F%22">Ballout F</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Thangaretnam+K%22">Thangaretnam K</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Que+J%22">Que J</searchLink>; Division of Digestive and Liver Diseases and Center for Human Development, Department of Medicine, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chen+XS%22">Chen XS</searchLink>; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22McDonald+OG%22">McDonald OG</searchLink>; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA; Department of Pathology, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Zaika+A%22">Zaika A</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Livingstone+A%22">Livingstone A</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Giordano+S%22">Giordano S</searchLink>; Department of Oncology, University of Torino and Candiolo Cancer Institute, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Shiekhattar+R%22">Shiekhattar R</searchLink>; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA; Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Lu+H%22">Lu H</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. Electronic address: heng.lu@med.miami.edu.<br /><searchLink fieldCode="AU" term="%22Peng+D%22">Peng D</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. Electronic address: dxp737@miami.edu.<br /><searchLink fieldCode="AU" term="%22El-Rifai+W%22">El-Rifai W</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA; Department of Veterans Affairs, Miami Healthcare System, Miami, FL, USA. Electronic address: wxe45@miami.edu.
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