Acidic bile salts induce APE1-dependent PRDX2 activation to drive oxaliplatin resistance via ferroptosis inhibition.
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| Title: | Acidic bile salts induce APE1-dependent PRDX2 activation to drive oxaliplatin resistance via ferroptosis inhibition. |
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| Authors: | Chen L; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA., Ballout F; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA., Chen Z; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA., Thangaretnam K; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA., Que J; Division of Digestive and Liver Diseases and Center for Human Development, Department of Medicine, Columbia University, New York, NY, USA., Chen XS; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA., McDonald OG; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA; Department of Pathology, Miller School of Medicine, University of Miami, Miami, FL, USA., Zaika A; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA., Livingstone A; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA., Giordano S; Department of Oncology, University of Torino and Candiolo Cancer Institute, Candiolo, Italy., Shiekhattar R; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA; Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA., Lu H; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. Electronic address: heng.lu@med.miami.edu., Peng D; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. Electronic address: dxp737@miami.edu., El-Rifai W; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA; Department of Veterans Affairs, Miami Healthcare System, Miami, FL, USA. Electronic address: wxe45@miami.edu. |
| Source: | Redox biology [Redox Biol] 2026 Sep; Vol. 95, pp. 104254. Date of Electronic Publication: 2026 Jun 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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