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Decoding cryptic defluorinases through a latent generative sequence landscape.

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Title: Decoding cryptic defluorinases through a latent generative sequence landscape.
Authors: Ji K; Department of Chemistry and Biochemistry, The University of Texas at Dallas Richardson TX 75080 USA sheel.dodani@utdallas.edu., Barnes SS; Department of Chemistry and Biochemistry, The University of Texas at Dallas Richardson TX 75080 USA sheel.dodani@utdallas.edu., Ziegler C; Department of Biological Sciences, The University of Texas at Dallas Richardson TX 75080 USA faruckm@utdallas.edu., Nikpey M; Department of Bioengineering, The University of Texas at Dallas Richardson TX 75080 USA., de la Paz JA; Department of Biological Sciences, The University of Texas at Dallas Richardson TX 75080 USA faruckm@utdallas.edu., Pack EK; Department of Chemistry and Biochemistry, The University of Texas at Dallas Richardson TX 75080 USA sheel.dodani@utdallas.edu., Kvasovs N; Department of Chemistry and Biochemistry, The University of Texas at Dallas Richardson TX 75080 USA sheel.dodani@utdallas.edu., Morcos F; Department of Biological Sciences, The University of Texas at Dallas Richardson TX 75080 USA faruckm@utdallas.edu.; Department of Bioengineering, The University of Texas at Dallas Richardson TX 75080 USA.; Department of Physics, The University of Texas at Dallas Richardson TX 75080 USA.; Center for Systems Biology, The University of Texas at Dallas Richardson TX 75080 USA., Dodani SC; Department of Chemistry and Biochemistry, The University of Texas at Dallas Richardson TX 75080 USA sheel.dodani@utdallas.edu.
Source: Chemical science [Chem Sci] 2026 May 26. Date of Electronic Publication: 2026 May 26.
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Ji+K%22">Ji K</searchLink>; Department of Chemistry and Biochemistry, The University of Texas at Dallas Richardson TX 75080 USA sheel.dodani@utdallas.edu.<br /><searchLink fieldCode="AU" term="%22Barnes+SS%22">Barnes SS</searchLink>; Department of Chemistry and Biochemistry, The University of Texas at Dallas Richardson TX 75080 USA sheel.dodani@utdallas.edu.<br /><searchLink fieldCode="AU" term="%22Ziegler+C%22">Ziegler C</searchLink>; Department of Biological Sciences, The University of Texas at Dallas Richardson TX 75080 USA faruckm@utdallas.edu.<br /><searchLink fieldCode="AU" term="%22Nikpey+M%22">Nikpey M</searchLink>; Department of Bioengineering, The University of Texas at Dallas Richardson TX 75080 USA.<br /><searchLink fieldCode="AU" term="%22de+la+Paz+JA%22">de la Paz JA</searchLink>; Department of Biological Sciences, The University of Texas at Dallas Richardson TX 75080 USA faruckm@utdallas.edu.<br /><searchLink fieldCode="AU" term="%22Pack+EK%22">Pack EK</searchLink>; Department of Chemistry and Biochemistry, The University of Texas at Dallas Richardson TX 75080 USA sheel.dodani@utdallas.edu.<br /><searchLink fieldCode="AU" term="%22Kvasovs+N%22">Kvasovs N</searchLink>; Department of Chemistry and Biochemistry, The University of Texas at Dallas Richardson TX 75080 USA sheel.dodani@utdallas.edu.<br /><searchLink fieldCode="AU" term="%22Morcos+F%22">Morcos F</searchLink>; Department of Biological Sciences, The University of Texas at Dallas Richardson TX 75080 USA faruckm@utdallas.edu.; Department of Bioengineering, The University of Texas at Dallas Richardson TX 75080 USA.; Department of Physics, The University of Texas at Dallas Richardson TX 75080 USA.; Center for Systems Biology, The University of Texas at Dallas Richardson TX 75080 USA.<br /><searchLink fieldCode="AU" term="%22Dodani+SC%22">Dodani SC</searchLink>; Department of Chemistry and Biochemistry, The University of Texas at Dallas Richardson TX 75080 USA sheel.dodani@utdallas.edu.
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        Value: 10.1039/d6sc02671k
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              Text: 2026 May 26
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