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Evaluating statistical models for overdispersed multi-omics data: a multiplex immunofluorescence case study.

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Title: Evaluating statistical models for overdispersed multi-omics data: a multiplex immunofluorescence case study.
Authors: Thomas CE; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States., Wesselink E; Division of Molecular Pathology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands., Takashima Y; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States., Huyghe JR; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States., Buchanan DD; Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Parkville, Australia.; Collaborative Centre for Genomic Cancer Medicine, The University of Melbourne, Victorian Comprehensive Cancer Centre, Parkville, Australia.; Genomic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Parkville, Victoria, Australia., Grant RC; Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Costa AD; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, United States., Ugai T; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States., Ogino S; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States.; Institute of Science Tokyo, Tokyo, Japan., Nowak JA; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States.; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States., Peters U; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States.; Department of Epidemiology, University of Washington, Seattle, Washington, United States., Phipps AI; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States.; Department of Epidemiology, University of Washington, Seattle, Washington, United States., Hsu L; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States.; Department of Biostatistics, University of Washington, Seattle, Washington, United States.
Source: American journal of epidemiology [Am J Epidemiol] 2026 Jun 15. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 7910653 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-6256 (Electronic) Linking ISSN: 00029262 NLM ISO Abbreviation: Am J Epidemiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Thomas+CE%22">Thomas CE</searchLink>; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States.<br /><searchLink fieldCode="AU" term="%22Wesselink+E%22">Wesselink E</searchLink>; Division of Molecular Pathology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Takashima+Y%22">Takashima Y</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Huyghe+JR%22">Huyghe JR</searchLink>; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States.<br /><searchLink fieldCode="AU" term="%22Buchanan+DD%22">Buchanan DD</searchLink>; Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Parkville, Australia.; Collaborative Centre for Genomic Cancer Medicine, The University of Melbourne, Victorian Comprehensive Cancer Centre, Parkville, Australia.; Genomic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Grant+RC%22">Grant RC</searchLink>; Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Costa+AD%22">Costa AD</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, United States.<br /><searchLink fieldCode="AU" term="%22Ugai+T%22">Ugai T</searchLink>; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States.<br /><searchLink fieldCode="AU" term="%22Ogino+S%22">Ogino S</searchLink>; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States.; Institute of Science Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nowak+JA%22">Nowak JA</searchLink>; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States.; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States.<br /><searchLink fieldCode="AU" term="%22Peters+U%22">Peters U</searchLink>; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States.; Department of Epidemiology, University of Washington, Seattle, Washington, United States.<br /><searchLink fieldCode="AU" term="%22Phipps+AI%22">Phipps AI</searchLink>; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States.; Department of Epidemiology, University of Washington, Seattle, Washington, United States.<br /><searchLink fieldCode="AU" term="%22Hsu+L%22">Hsu L</searchLink>; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States.; Department of Biostatistics, University of Washington, Seattle, Washington, United States.
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              Text: 2026 Jun 15
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