AlphaFold reveals how pathogenic Leptospira use cross-kingdom thiol-disulfide exchange to evade the complement membrane attack complex.

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Title: AlphaFold reveals how pathogenic Leptospira use cross-kingdom thiol-disulfide exchange to evade the complement membrane attack complex.
Authors: Hinds A; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Chester, Neston, United Kingdom., Johnson E; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom.; Computational Biology Facility, LIV-SRF, MerseyBio, University of Liverpool, Liverpool, United Kingdom., Staton G; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Chester, Neston, United Kingdom., Njume FN; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Chester, Neston, United Kingdom., Crosby-Durrani HE; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Chester, Neston, United Kingdom., Nally JE; Infectious Bacterial Disease Research Unit, National Animal Disease Centre, United States Department of Agriculture, Agricultural Research Service, Ames, Iowa, USA., Carter S; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Chester, Neston, United Kingdom., Rigden DJ; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom., Evans NJ; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Chester, Neston, United Kingdom.
Source: MBio [mBio] 2026 Jul 08; Vol. 17 (7), pp. e0087826. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2150-7511
DOI:10.1128/mbio.00878-26