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Lonvoguran Ziclumeran - In Vivo CRISPR Gene Editing in Hereditary Angioedema.

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Title: Lonvoguran Ziclumeran - In Vivo CRISPR Gene Editing in Hereditary Angioedema.
Authors: Cohn DM; Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam., Gurugama P; Cambridge University Hospitals, NHS Foundation Trust, Cambridge, United Kingdom., Longhurst HJ; Te Toka Tumai, Department of Immunology, Auckland City Hospital, Auckland, New Zealand.; Department of Medicine, University of Auckland, Auckland, New Zealand., Aygören-Pürsün E; Department of Children and Adolescents, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany., Craig TJ; Penn State University Departments of Medicine, Pediatrics, OB/GYN Maternal Fetal Medicine, and Biomedical Sciences, Hershey, PA.; Health Allergy, Asthma, and Immunology, Department of Immunology, Vinmec Times City and VinUniversity, Hanoi., Farkas H; Hungarian Angioedema Center of Reference and Excellence, Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary., Jacobs J; Allergy and Asthma Clinical Research, Walnut Creek, CA., Lumry WR; Allergy and Asthma Research Associates Research Center, Dallas., Magerl M; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin.; Fraunhofer Institute for Translational Medicine and Pharmacology, Immunology and Allergology, Berlin., Peter J; Division of Allergology and Clinical Immunology, Department of Medicine, Groote Schuur Hospital, University of Cape Town and Allergy and Immunology Unit, University of Cape Town Lung Institute, Cape Town, South Africa., Riedl MA; University of California, San Diego, La Jolla., Maag D; Intellia Therapeutics, Cambridge, MA., Golden A; Intellia Therapeutics, Cambridge, MA., Shah MY; Intellia Therapeutics, Cambridge, MA., Sutherland A; Intellia Therapeutics, Cambridge, MA., Miller CR; Intellia Therapeutics, Cambridge, MA., Abdelhady AM; Intellia Therapeutics, Cambridge, MA., Xu Y; Intellia Therapeutics, Cambridge, MA., Butler JS; Intellia Therapeutics, Cambridge, MA., Lebwohl D; Intellia Therapeutics, Cambridge, MA., Leonard J; Intellia Therapeutics, Cambridge, MA., Banerji A; Massachusetts General Hospital, Boston.; Harvard Medical School, Boston.
Corporate Authors: HAELO Investigators
Source: The New England journal of medicine [N Engl J Med] 2026 Jun 13. Date of Electronic Publication: 2026 Jun 13.
Publication Type: Journal Article
Journal Info: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE
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  Data: Lonvoguran Ziclumeran - In Vivo CRISPR Gene Editing in Hereditary Angioedema.
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  Data: <searchLink fieldCode="AU" term="%22Cohn+DM%22">Cohn DM</searchLink>; Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam.<br /><searchLink fieldCode="AU" term="%22Gurugama+P%22">Gurugama P</searchLink>; Cambridge University Hospitals, NHS Foundation Trust, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Longhurst+HJ%22">Longhurst HJ</searchLink>; Te Toka Tumai, Department of Immunology, Auckland City Hospital, Auckland, New Zealand.; Department of Medicine, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Aygören-Pürsün+E%22">Aygören-Pürsün E</searchLink>; Department of Children and Adolescents, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Craig+TJ%22">Craig TJ</searchLink>; Penn State University Departments of Medicine, Pediatrics, OB/GYN Maternal Fetal Medicine, and Biomedical Sciences, Hershey, PA.; Health Allergy, Asthma, and Immunology, Department of Immunology, Vinmec Times City and VinUniversity, Hanoi.<br /><searchLink fieldCode="AU" term="%22Farkas+H%22">Farkas H</searchLink>; Hungarian Angioedema Center of Reference and Excellence, Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Jacobs+J%22">Jacobs J</searchLink>; Allergy and Asthma Clinical Research, Walnut Creek, CA.<br /><searchLink fieldCode="AU" term="%22Lumry+WR%22">Lumry WR</searchLink>; Allergy and Asthma Research Associates Research Center, Dallas.<br /><searchLink fieldCode="AU" term="%22Magerl+M%22">Magerl M</searchLink>; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin.; Fraunhofer Institute for Translational Medicine and Pharmacology, Immunology and Allergology, Berlin.<br /><searchLink fieldCode="AU" term="%22Peter+J%22">Peter J</searchLink>; Division of Allergology and Clinical Immunology, Department of Medicine, Groote Schuur Hospital, University of Cape Town and Allergy and Immunology Unit, University of Cape Town Lung Institute, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Riedl+MA%22">Riedl MA</searchLink>; University of California, San Diego, La Jolla.<br /><searchLink fieldCode="AU" term="%22Maag+D%22">Maag D</searchLink>; Intellia Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Golden+A%22">Golden A</searchLink>; Intellia Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Shah+MY%22">Shah MY</searchLink>; Intellia Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Sutherland+A%22">Sutherland A</searchLink>; Intellia Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Miller+CR%22">Miller CR</searchLink>; Intellia Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Abdelhady+AM%22">Abdelhady AM</searchLink>; Intellia Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Intellia Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Butler+JS%22">Butler JS</searchLink>; Intellia Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Lebwohl+D%22">Lebwohl D</searchLink>; Intellia Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Leonard+J%22">Leonard J</searchLink>; Intellia Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Banerji+A%22">Banerji A</searchLink>; Massachusetts General Hospital, Boston.; Harvard Medical School, Boston.
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