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The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma.

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Title: The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma.
Authors: Bayanjargal A; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, United States.; Medical Scientist Training Program, The Ohio State University, Columbus, United States.; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, United States., Taslim C; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, United States., Showpnil IA; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, United States., Selich-Anderson J; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, United States., Crow JC; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, United States., Zhou R; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, United States.; Ohio State Biochemistry Program, Columbus, United States., Lessnick SL; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, United States.; Medical Scientist Training Program, The Ohio State University, Columbus, United States.; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, United States.; Department of Pediatrics, The Ohio State Univeristy, Columbus, United States.; Division of Pediatric Heme/Onc/BMT, The Ohio State University College of Medicine, Columbus, United States., Theisen ER; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, United States.; Medical Scientist Training Program, The Ohio State University, Columbus, United States.; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, United States.; Ohio State Biochemistry Program, Columbus, United States.; Department of Pediatrics, The Ohio State Univeristy, Columbus, United States.
Source: ELife [Elife] 2026 Jun 15; Vol. 13. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma.
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  Data: <searchLink fieldCode="AU" term="%22Bayanjargal+A%22">Bayanjargal A</searchLink>; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, United States.; Medical Scientist Training Program, The Ohio State University, Columbus, United States.; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, United States.<br /><searchLink fieldCode="AU" term="%22Taslim+C%22">Taslim C</searchLink>; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, United States.<br /><searchLink fieldCode="AU" term="%22Showpnil+IA%22">Showpnil IA</searchLink>; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, United States.<br /><searchLink fieldCode="AU" term="%22Selich-Anderson+J%22">Selich-Anderson J</searchLink>; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, United States.<br /><searchLink fieldCode="AU" term="%22Crow+JC%22">Crow JC</searchLink>; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, United States.<br /><searchLink fieldCode="AU" term="%22Zhou+R%22">Zhou R</searchLink>; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, United States.; Ohio State Biochemistry Program, Columbus, United States.<br /><searchLink fieldCode="AU" term="%22Lessnick+SL%22">Lessnick SL</searchLink>; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, United States.; Medical Scientist Training Program, The Ohio State University, Columbus, United States.; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, United States.; Department of Pediatrics, The Ohio State Univeristy, Columbus, United States.; Division of Pediatric Heme/Onc/BMT, The Ohio State University College of Medicine, Columbus, United States.<br /><searchLink fieldCode="AU" term="%22Theisen+ER%22">Theisen ER</searchLink>; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, United States.; Medical Scientist Training Program, The Ohio State University, Columbus, United States.; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, United States.; Ohio State Biochemistry Program, Columbus, United States.; Department of Pediatrics, The Ohio State Univeristy, Columbus, United States.
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  Data: <searchLink fieldCode="JN" term="%22101579614%22">ELife</searchLink> [Elife] 2026 Jun 15; Vol. 13. <i>Date of Electronic Publication: </i>2026 Jun 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22eLife+Sciences+Publications%2C+Ltd%22">eLife Sciences Publications, Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101579614 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2050-084X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222050084X%22">2050084X </searchLink><i>NLM ISO Abbreviation: </i>Elife <i>Subsets: </i>MEDLINE
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        Value: 10.7554/eLife.95626
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        Text: English
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      – TitleFull: The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma.
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              Text: 2026 Jun 15
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