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A quantitative method to estimate free interleukin-6 among patients treated with the interleukin-6 ligand inhibitor ziltivekimab: comparison to C-reactive protein with implications for the ZEUS, HERMES, and ARTEMIS cardiovascular outcomes trials.

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Title: A quantitative method to estimate free interleukin-6 among patients treated with the interleukin-6 ligand inhibitor ziltivekimab: comparison to C-reactive protein with implications for the ZEUS, HERMES, and ARTEMIS cardiovascular outcomes trials.
Authors: Nolain P; Novo Nordisk A/S, Søborg, Denmark., Fugger M; Novo Nordisk A/S, Søborg, Denmark., Hellinghus BT; Novo Nordisk A/S, Søborg, Denmark., Hilgendorf I; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Virchow Klinikum, Charité-Universitaetsmedizin, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany., Højen JF; Novo Nordisk A/S, Søborg, Denmark., Libby P; Heart and Vascular Institute, Mass General Brigham, Harvard Medical School, Boston, MA, USA., Liuzzo G; Department of Cardiovascular and Pulmonary Sciences, Catholic University of Sacred Heart, Rome, Italy; Department of Cardiovascular Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Matter CM; Department of Cardiology, Zurich University Hospital, Zurich, Switzerland., Tuttle KR; Providence Medical Research Center, Providence Inland Northwest Health, Spokane, WA, USA; Nephrology Division, University of Washington School of Medicine, Seattle, WA, USA., Ridker PM; Center for Cardiovascular Disease Prevention and the Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA. Electronic address: pridker@bwh.harvard.edu.
Source: Atherosclerosis [Atherosclerosis] 2026 Jun; Vol. 417, pp. 120742. Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0242543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1484 (Electronic) Linking ISSN: 00219150 NLM ISO Abbreviation: Atherosclerosis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A quantitative method to estimate free interleukin-6 among patients treated with the interleukin-6 ligand inhibitor ziltivekimab: comparison to C-reactive protein with implications for the ZEUS, HERMES, and ARTEMIS cardiovascular outcomes trials.
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  Data: <searchLink fieldCode="AU" term="%22Nolain+P%22">Nolain P</searchLink>; Novo Nordisk A/S, Søborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Fugger+M%22">Fugger M</searchLink>; Novo Nordisk A/S, Søborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Hellinghus+BT%22">Hellinghus BT</searchLink>; Novo Nordisk A/S, Søborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Hilgendorf+I%22">Hilgendorf I</searchLink>; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Virchow Klinikum, Charité-Universitaetsmedizin, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Højen+JF%22">Højen JF</searchLink>; Novo Nordisk A/S, Søborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Libby+P%22">Libby P</searchLink>; Heart and Vascular Institute, Mass General Brigham, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Liuzzo+G%22">Liuzzo G</searchLink>; Department of Cardiovascular and Pulmonary Sciences, Catholic University of Sacred Heart, Rome, Italy; Department of Cardiovascular Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Matter+CM%22">Matter CM</searchLink>; Department of Cardiology, Zurich University Hospital, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tuttle+KR%22">Tuttle KR</searchLink>; Providence Medical Research Center, Providence Inland Northwest Health, Spokane, WA, USA; Nephrology Division, University of Washington School of Medicine, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Ridker+PM%22">Ridker PM</searchLink>; Center for Cardiovascular Disease Prevention and the Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA. Electronic address: pridker@bwh.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%220242543%22">Atherosclerosis</searchLink> [Atherosclerosis] 2026 Jun; Vol. 417, pp. 120742. <i>Date of Electronic Publication: </i>2026 May 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>0242543 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-1484 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219150%22">00219150 </searchLink><i>NLM ISO Abbreviation: </i>Atherosclerosis <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun
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