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Oncogenic KRAS-driven type I interferon signalling primes pancreatic cancer for necroptosis.

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Title: Oncogenic KRAS-driven type I interferon signalling primes pancreatic cancer for necroptosis.
Authors: Tishina S; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Dahlhaus A; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Manik M; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Mulalic L; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Murr J; Translational Pancreatic Cancer Research Centre, TUM School of Medicine and Health, Department of Clinical Medicine - Clinical Department for Internal Medicine II, TUM University Hospital, Technical University of Munich, Munich, Germany.; Centre for Organoid Systems (COS), Technical University Munich (TUM), Garching, Germany., Kotliar M; Cincinnati Children's Hospital Medical Center, Division of Allergy and Immunology, Cincinnati, OH, USA., Rakhsh-Khorshid H; University of Cologne, Faculty of Medicine and University Hospital Cologne, Centre for Biochemistry, Cologne, Germany., Kostopoulou M; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Hocher F; University of Kiel, Institute for Experimental Cancer Research, Kiel, Germany., Stroh J; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Beck J; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Williams RM; Fox Chase Cancer Center, Cancer Signaling and Microenvironment Program, Philadelphia, PA, USA., Balta GG; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Liu F; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Abdallah AT; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Institute of Medical Statistics and Computational Biology, Faculty of Medicine, University of Cologne, Cologne, Germany., Bebber CM; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Reese M; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Lim JKM; Heinrich Heine University, Medical Faculty and University Hospital Düsseldorf, Institute of Neuropathology, Düsseldorf, Germany., Quaas A; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany., Brägelmann J; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; University Hospital Cologne, Mildred Scheel School of Oncology, Cologne, Germany.; University Hospital Cologne, Centre for Molecular Medicine Cologne (CMMC), Cologne, Germany., Pasparakis M; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; University Hospital Cologne, Centre for Molecular Medicine Cologne (CMMC), Cologne, Germany.; University of Cologne, Institute for Genetics, Cologne, Germany., Beleggia F; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Balachandran S; Fox Chase Cancer Center, Cancer Signaling and Microenvironment Program, Philadelphia, PA, USA., Trauzold A; University of Kiel, Institute for Experimental Cancer Research, Kiel, Germany.; University Hospital Schleswig-Holstein (UKSH), Department of Gynecology and Obstetrics, Campus Kiel, Kiel, Germany., Liccardi G; University of Cologne, Faculty of Medicine and University Hospital Cologne, Centre for Biochemistry, Cologne, Germany., Astsaturov I; Fox Chase Cancer Center, Molecular Therapeutics Program, Philadelphia, PA, USA., Reichert M; Translational Pancreatic Cancer Research Centre, TUM School of Medicine and Health, Department of Clinical Medicine - Clinical Department for Internal Medicine II, TUM University Hospital, Technical University of Munich, Munich, Germany.; Cincinnati Children's Hospital Medical Center, Division of Allergy and Immunology, Cincinnati, OH, USA.; German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and TUM University Hospital, Munich, Germany.; Bavarian Cancer Research Centre (BZKF), Munich, Germany., Androulidaki A; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., von Karstedt S; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany. s.vonkarstedt@uni-koeln.de.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. s.vonkarstedt@uni-koeln.de.; University Hospital Cologne, Centre for Molecular Medicine Cologne (CMMC), Cologne, Germany. s.vonkarstedt@uni-koeln.de.
Source: Nature communications [Nat Commun] 2026 Jun 15; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Oncogenic KRAS-driven type I interferon signalling primes pancreatic cancer for necroptosis.
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  Data: <searchLink fieldCode="AU" term="%22Tishina+S%22">Tishina S</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Dahlhaus+A%22">Dahlhaus A</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Manik+M%22">Manik M</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Mulalic+L%22">Mulalic L</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Murr+J%22">Murr J</searchLink>; Translational Pancreatic Cancer Research Centre, TUM School of Medicine and Health, Department of Clinical Medicine - Clinical Department for Internal Medicine II, TUM University Hospital, Technical University of Munich, Munich, Germany.; Centre for Organoid Systems (COS), Technical University Munich (TUM), Garching, Germany.<br /><searchLink fieldCode="AU" term="%22Kotliar+M%22">Kotliar M</searchLink>; Cincinnati Children's Hospital Medical Center, Division of Allergy and Immunology, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Rakhsh-Khorshid+H%22">Rakhsh-Khorshid H</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Centre for Biochemistry, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Kostopoulou+M%22">Kostopoulou M</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Hocher+F%22">Hocher F</searchLink>; University of Kiel, Institute for Experimental Cancer Research, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Stroh+J%22">Stroh J</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Beck+J%22">Beck J</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Williams+RM%22">Williams RM</searchLink>; Fox Chase Cancer Center, Cancer Signaling and Microenvironment Program, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Balta+GG%22">Balta GG</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Liu+F%22">Liu F</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Abdallah+AT%22">Abdallah AT</searchLink>; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Institute of Medical Statistics and Computational Biology, Faculty of Medicine, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Bebber+CM%22">Bebber CM</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Reese+M%22">Reese M</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Lim+JKM%22">Lim JKM</searchLink>; Heinrich Heine University, Medical Faculty and University Hospital Düsseldorf, Institute of Neuropathology, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Quaas+A%22">Quaas A</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Brägelmann+J%22">Brägelmann J</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; University Hospital Cologne, Mildred Scheel School of Oncology, Cologne, Germany.; University Hospital Cologne, Centre for Molecular Medicine Cologne (CMMC), Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Pasparakis+M%22">Pasparakis M</searchLink>; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; University Hospital Cologne, Centre for Molecular Medicine Cologne (CMMC), Cologne, Germany.; University of Cologne, Institute for Genetics, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Beleggia+F%22">Beleggia F</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Balachandran+S%22">Balachandran S</searchLink>; Fox Chase Cancer Center, Cancer Signaling and Microenvironment Program, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Trauzold+A%22">Trauzold A</searchLink>; University of Kiel, Institute for Experimental Cancer Research, Kiel, Germany.; University Hospital Schleswig-Holstein (UKSH), Department of Gynecology and Obstetrics, Campus Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Liccardi+G%22">Liccardi G</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Centre for Biochemistry, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Astsaturov+I%22">Astsaturov I</searchLink>; Fox Chase Cancer Center, Molecular Therapeutics Program, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Reichert+M%22">Reichert M</searchLink>; Translational Pancreatic Cancer Research Centre, TUM School of Medicine and Health, Department of Clinical Medicine - Clinical Department for Internal Medicine II, TUM University Hospital, Technical University of Munich, Munich, Germany.; Cincinnati Children's Hospital Medical Center, Division of Allergy and Immunology, Cincinnati, OH, USA.; German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and TUM University Hospital, Munich, Germany.; Bavarian Cancer Research Centre (BZKF), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Androulidaki+A%22">Androulidaki A</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22von+Karstedt+S%22">von Karstedt S</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany. s.vonkarstedt@uni-koeln.de.; CECAD Cluster of Excellence, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. s.vonkarstedt@uni-koeln.de.; University Hospital Cologne, Centre for Molecular Medicine Cologne (CMMC), Cologne, Germany. s.vonkarstedt@uni-koeln.de.
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