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mRNA-based influenza vaccine expands the B cell response breadth in humans.

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Title: mRNA-based influenza vaccine expands the B cell response breadth in humans.
Authors: Matz HC; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Yu TG; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA., Dixit K; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Kikawa C; Department of Genome Sciences, Medical Scientist Training Program, University of Washington, Seattle, WA, USA., Zhou JQ; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Pena Alzua G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA., Peyton L; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.; Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Madsen A; Influenza Centre, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Microbiology, Haukeland University Hospital, Bergen, Norway., Han F; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Farrell AG; Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA, USA., Hoelzl R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Schmitz AJ; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Horvath SC; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Keplinger HK; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Strnad BS; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Hoegger MJ; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Middleton WD; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Klebert MK; Infectious Disease Clinical Research Unit, Washington University School of Medicine, St. Louis, MO, USA., Lin NH; Moderna, Cambridge, MA, USA., Nachbagauer R; Moderna, Cambridge, MA, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ignaz Semmelweis Institute, Interuniversity Institute for Infection Research, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Science Outreach and Pandemic Preparedness at the Medical University of Vienna, Medical University of Vienna, Vienna, Austria., Paris R; Moderna, Cambridge, MA, USA., Bloom JD; Fred Hutch Cancer Center, Seattle, WA, USA.; Howard Hughes Medical Institute, Seattle, WA, USA., Turner JS; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Presti RM; Infectious Disease Clinical Research Unit, Washington University School of Medicine, St. Louis, MO, USA.; Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA., Lee J; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA. jiwonjlee@korea.ac.kr.; Department of Convergence Medicine, Korea University College of Medicine, Seoul, Republic of Korea. jiwonjlee@korea.ac.kr.; Vaccine Innovation Center, Korea University College of Medicine, Seoul, Republic of Korea. jiwonjlee@korea.ac.kr., Ellebedy AH; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. ellebedy@wustl.edu.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO, USA. ellebedy@wustl.edu.; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA. ellebedy@wustl.edu.
Source: Nature immunology [Nat Immunol] 2026 Aug; Vol. 27 (8), pp. 1666-1677. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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  Data: mRNA-based influenza vaccine expands the B cell response breadth in humans.
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  Data: <searchLink fieldCode="AU" term="%22Matz+HC%22">Matz HC</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Yu+TG%22">Yu TG</searchLink>; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.<br /><searchLink fieldCode="AU" term="%22Dixit+K%22">Dixit K</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Kikawa+C%22">Kikawa C</searchLink>; Department of Genome Sciences, Medical Scientist Training Program, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+JQ%22">Zhou JQ</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Pena+Alzua+G%22">Pena Alzua G</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Peyton+L%22">Peyton L</searchLink>; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.; Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.<br /><searchLink fieldCode="AU" term="%22Madsen+A%22">Madsen A</searchLink>; Influenza Centre, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Microbiology, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Han+F%22">Han F</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Farrell+AG%22">Farrell AG</searchLink>; Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Hoelzl+R%22">Hoelzl R</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Schmitz+AJ%22">Schmitz AJ</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Horvath+SC%22">Horvath SC</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Keplinger+HK%22">Keplinger HK</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Strnad+BS%22">Strnad BS</searchLink>; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Hoegger+MJ%22">Hoegger MJ</searchLink>; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Middleton+WD%22">Middleton WD</searchLink>; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Klebert+MK%22">Klebert MK</searchLink>; Infectious Disease Clinical Research Unit, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Lin+NH%22">Lin NH</searchLink>; Moderna, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nachbagauer+R%22">Nachbagauer R</searchLink>; Moderna, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Krammer+F%22">Krammer F</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ignaz Semmelweis Institute, Interuniversity Institute for Infection Research, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Science Outreach and Pandemic Preparedness at the Medical University of Vienna, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Paris+R%22">Paris R</searchLink>; Moderna, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bloom+JD%22">Bloom JD</searchLink>; Fred Hutch Cancer Center, Seattle, WA, USA.; Howard Hughes Medical Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Turner+JS%22">Turner JS</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Presti+RM%22">Presti RM</searchLink>; Infectious Disease Clinical Research Unit, Washington University School of Medicine, St. Louis, MO, USA.; Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA. jiwonjlee@korea.ac.kr.; Department of Convergence Medicine, Korea University College of Medicine, Seoul, Republic of Korea. jiwonjlee@korea.ac.kr.; Vaccine Innovation Center, Korea University College of Medicine, Seoul, Republic of Korea. jiwonjlee@korea.ac.kr.<br /><searchLink fieldCode="AU" term="%22Ellebedy+AH%22">Ellebedy AH</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. ellebedy@wustl.edu.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO, USA. ellebedy@wustl.edu.; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA. ellebedy@wustl.edu.
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  Data: <searchLink fieldCode="JN" term="%22100941354%22">Nature immunology</searchLink> [Nat Immunol] 2026 Aug; Vol. 27 (8), pp. 1666-1677. <i>Date of Electronic Publication: </i>2026 Jun 15.
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