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Activity-dependent adaptive deep brain stimulation improves gait in Parkinson's disease.

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Title: Activity-dependent adaptive deep brain stimulation improves gait in Parkinson's disease.
Authors: Scafa S; Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; Institute of Digital Technologies for Personalized Healthcare (MeDiTech), University of Southern Switzerland (SUPSI), Viganello, Switzerland., de Seta V; Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Wang R; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; Neuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland., Sánchez López P; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; Neuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland., Sánchez López A; Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Varescon C; Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Sakr I; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; Neuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland., Bérard N; Department of Neurosurgery, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland., Bole-Feysot L; Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Deschenaux C; Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Enderli I; Neuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland., Thenaisie Y; Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Burri M; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Merlos F; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Fleury V; Department of Neurology, Hôpitaux Universitaires de Genève (HUG), Geneva, Switzerland.; Faculty of Medicine, University of Geneva, Geneva, Switzerland., Wicki B; Department of Neurology, Hôpital du Valais, Sion, Switzerland., Accolla E; Department of Neurology, Hôpital Fribourgeois, Fribourg, Switzerland.; Department of Neurology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland., Tziakouri A; Department of Neurology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland., Hübsch C; Department of Neurology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland., Castro Jiménez M; Department of Neurology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland., Bally JF; Department of Neurology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland., Puiatti A; Institute of Digital Technologies for Personalized Healthcare (MeDiTech), University of Southern Switzerland (SUPSI), Viganello, Switzerland., Lee K; Wyss Center for Bio and Neuroengineering, Geneva, Switzerland., Lorach H; Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Collomb-Clerc A; Neuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland., Bloch J; Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; Neuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.; Department of Neurosurgery, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland., Moraud EM; Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland. Eduardo.Moraud@epfl.ch.; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. Eduardo.Moraud@epfl.ch.; Neuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland. Eduardo.Moraud@epfl.ch.
Source: Nature medicine [Nat Med] 2026 Jun 15. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: Activity-dependent adaptive deep brain stimulation improves gait in Parkinson's disease.
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  Data: <searchLink fieldCode="AU" term="%22Scafa+S%22">Scafa S</searchLink>; Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; Institute of Digital Technologies for Personalized Healthcare (MeDiTech), University of Southern Switzerland (SUPSI), Viganello, Switzerland.<br /><searchLink fieldCode="AU" term="%22de+Seta+V%22">de Seta V</searchLink>; Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wang+R%22">Wang R</searchLink>; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; 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NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; Neuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bérard+N%22">Bérard N</searchLink>; Department of Neurosurgery, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bole-Feysot+L%22">Bole-Feysot L</searchLink>; Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Deschenaux+C%22">Deschenaux C</searchLink>; Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Enderli+I%22">Enderli I</searchLink>; 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Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; Neuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.; Department of Neurosurgery, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Moraud+EM%22">Moraud EM</searchLink>; Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland. Eduardo.Moraud@epfl.ch.; NeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. Eduardo.Moraud@epfl.ch.; Neuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland. Eduardo.Moraud@epfl.ch.
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