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Mechanisms of increased Alzheimer's disease pathology with R47H and R62H TREM2 variants.

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Title: Mechanisms of increased Alzheimer's disease pathology with R47H and R62H TREM2 variants.
Authors: Fancy NN; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Willumsen N; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Chau VMN; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Boulger SL; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Whitwell HJ; Department of Metabolism, Digestion and Reproduction, Section of Bioanalytical Chemistry, Division of Systems Medicine, Sir Alexander Fleming Building, Imperial College London, London, UK.; Department of Metabolism, Digestion and Reproduction, National Phenome Centre and Imperial Clinical Phenotyping Centre, Imperial College London, London, UK., Wang W; Department of Metabolism, Digestion and Reproduction, Section of Bioanalytical Chemistry, Division of Systems Medicine, Sir Alexander Fleming Building, Imperial College London, London, UK.; Department of Metabolism, Digestion and Reproduction, National Phenome Centre and Imperial Clinical Phenotyping Centre, Imperial College London, London, UK., Avot B; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Thomas M; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Talbot-Martin J; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Tsartsalis S; Department of Psychiatry, University Hospitals of Geneva, Switzerland+ Centre for Psychiatric Neuroscience, Lausanne University Hospitals, Lausanne, Switzerland., Khozoie C; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., McGarry A; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.; Department of Basic and Clinical Neuroscience, Institute of Psychology, Psychiatry and Neuroscience, King's College London, London, UK., Schneegans E; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Yagoubi R; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Cheung TKD; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Papageorgopoulou M; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Adair E; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Cooper B; Department of Metabolism, Digestion and Reproduction, National Phenome Centre and Imperial Clinical Phenotyping Centre, Imperial College London, London, UK., Davey K; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.; Department of Basic and Clinical Neuroscience, Institute of Psychology, Psychiatry and Neuroscience, King's College London, London, UK.; UK Dementia Research Institute at King's College London, London, UK., Smith AM; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.; Department of Pharmacology and Clinical Pharmacology and Centre for Brain Research, University of Auckland, Auckland, New Zealand., Scotton W; Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London, UK.; Department of Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK., Hardy J; Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London, UK., Matthews PM; UK Dementia Research Institute at Imperial College, London, UK. p.matthews@imperial.ac.uk.; Department of Brain Sciences, Imperial College London, London, UK. p.matthews@imperial.ac.uk.; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Didcot, Oxon, UK. p.matthews@imperial.ac.uk., Jackson JS; UK Dementia Research Institute at Imperial College, London, UK. johanna.jackson@imperial.ac.uk.; Department of Brain Sciences, Imperial College London, London, UK. johanna.jackson@imperial.ac.uk.
Source: Acta neuropathologica [Acta Neuropathol] 2026 Jun 15; Vol. 151 (1). Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
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  Data: Mechanisms of increased Alzheimer's disease pathology with R47H and R62H TREM2 variants.
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  Data: <searchLink fieldCode="AU" term="%22Fancy+NN%22">Fancy NN</searchLink>; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Willumsen+N%22">Willumsen N</searchLink>; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Chau+VMN%22">Chau VMN</searchLink>; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Boulger+SL%22">Boulger SL</searchLink>; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Whitwell+HJ%22">Whitwell HJ</searchLink>; Department of Metabolism, Digestion and Reproduction, Section of Bioanalytical Chemistry, Division of Systems Medicine, Sir Alexander Fleming Building, Imperial College London, London, UK.; Department of Metabolism, Digestion and Reproduction, National Phenome Centre and Imperial Clinical Phenotyping Centre, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Metabolism, Digestion and Reproduction, Section of Bioanalytical Chemistry, Division of Systems Medicine, Sir Alexander Fleming Building, Imperial College London, London, UK.; Department of Metabolism, Digestion and Reproduction, National Phenome Centre and Imperial Clinical Phenotyping Centre, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Avot+B%22">Avot B</searchLink>; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Thomas+M%22">Thomas M</searchLink>; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Talbot-Martin+J%22">Talbot-Martin J</searchLink>; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Tsartsalis+S%22">Tsartsalis S</searchLink>; Department of Psychiatry, University Hospitals of Geneva, Switzerland+ Centre for Psychiatric Neuroscience, Lausanne University Hospitals, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Khozoie+C%22">Khozoie C</searchLink>; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22McGarry+A%22">McGarry A</searchLink>; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.; Department of Basic and Clinical Neuroscience, Institute of Psychology, Psychiatry and Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Schneegans+E%22">Schneegans E</searchLink>; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Yagoubi+R%22">Yagoubi R</searchLink>; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Cheung+TKD%22">Cheung TKD</searchLink>; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Papageorgopoulou+M%22">Papageorgopoulou M</searchLink>; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Adair+E%22">Adair E</searchLink>; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Cooper+B%22">Cooper B</searchLink>; Department of Metabolism, Digestion and Reproduction, National Phenome Centre and Imperial Clinical Phenotyping Centre, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Davey+K%22">Davey K</searchLink>; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.; Department of Basic and Clinical Neuroscience, Institute of Psychology, Psychiatry and Neuroscience, King's College London, London, UK.; UK Dementia Research Institute at King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Smith+AM%22">Smith AM</searchLink>; UK Dementia Research Institute at Imperial College, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.; Department of Pharmacology and Clinical Pharmacology and Centre for Brain Research, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Scotton+W%22">Scotton W</searchLink>; Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London, UK.; Department of Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Hardy+J%22">Hardy J</searchLink>; Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Matthews+PM%22">Matthews PM</searchLink>; UK Dementia Research Institute at Imperial College, London, UK. p.matthews@imperial.ac.uk.; Department of Brain Sciences, Imperial College London, London, UK. p.matthews@imperial.ac.uk.; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Didcot, Oxon, UK. p.matthews@imperial.ac.uk.<br /><searchLink fieldCode="AU" term="%22Jackson+JS%22">Jackson JS</searchLink>; UK Dementia Research Institute at Imperial College, London, UK. johanna.jackson@imperial.ac.uk.; Department of Brain Sciences, Imperial College London, London, UK. johanna.jackson@imperial.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%220412041%22">Acta neuropathologica</searchLink> [Acta Neuropathol] 2026 Jun 15; Vol. 151 (1). <i>Date of Electronic Publication: </i>2026 Jun 15.
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