Amphiregulin drives EGFR-dependent genome stability in colorectal cancer and represents a targetable vulnerability.

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Title: Amphiregulin drives EGFR-dependent genome stability in colorectal cancer and represents a targetable vulnerability.
Authors: Park SJ; Department of Physiology, Jeonbuk National University Medical School, Jeonju, Republic of Korea., Lee SW; BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, Republic of Korea.; School of Life Sciences & Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea., Moon H; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea., Jung SM; BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, Republic of Korea.; School of Life Sciences & Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea., Kim JM; Department of Pathology, Konyang University College of Medicine, Daejeon, Republic of Korea., Lee DS; BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, Republic of Korea. lee1@knu.ac.kr.; School of Life Sciences & Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea. lee1@knu.ac.kr., Choi EH; Department of Biotechnology, Korea National University of Transportation, Chungbuk, Republic of Korea. ehchoi@ut.ac.kr.
Source: Oncogene [Oncogene] 2026 Aug; Vol. 45 (29), pp. 2914-2931. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Amphiregulin drives EGFR-dependent genome stability in colorectal cancer and represents a targetable vulnerability.
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  Data: <searchLink fieldCode="AU" term="%22Park+SJ%22">Park SJ</searchLink>; Department of Physiology, Jeonbuk National University Medical School, Jeonju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+SW%22">Lee SW</searchLink>; BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, Republic of Korea.; School of Life Sciences & Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Moon+H%22">Moon H</searchLink>; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jung+SM%22">Jung SM</searchLink>; BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, Republic of Korea.; School of Life Sciences & Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+JM%22">Kim JM</searchLink>; Department of Pathology, Konyang University College of Medicine, Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+DS%22">Lee DS</searchLink>; BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, Republic of Korea. lee1@knu.ac.kr.; School of Life Sciences & Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea. lee1@knu.ac.kr.<br /><searchLink fieldCode="AU" term="%22Choi+EH%22">Choi EH</searchLink>; Department of Biotechnology, Korea National University of Transportation, Chungbuk, Republic of Korea. ehchoi@ut.ac.kr.
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  Data: <searchLink fieldCode="JN" term="%228711562%22">Oncogene</searchLink> [Oncogene] 2026 Aug; Vol. 45 (29), pp. 2914-2931. <i>Date of Electronic Publication: </i>2026 Jun 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8711562 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5594 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209509232%22">09509232 </searchLink><i>NLM ISO Abbreviation: </i>Oncogene <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1038/s41388-026-03850-5
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      – Code: eng
        Text: English
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        StartPage: 2914
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      – TitleFull: Amphiregulin drives EGFR-dependent genome stability in colorectal cancer and represents a targetable vulnerability.
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            NameFull: Park SJ
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            NameFull: Lee SW
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            NameFull: Moon H
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            – D: 01
              M: 08
              Text: 2026 Aug
              Type: published
              Y: 2026
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              Value: 45
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