Increasing intrinsic protein disorder improves CD8+ immunogenicity for a SARS CoV2 vaccine candidate antigen.

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Title: Increasing intrinsic protein disorder improves CD8+ immunogenicity for a SARS CoV2 vaccine candidate antigen.
Authors: Wan L; Cancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA., Xie B; Immunology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA., Shuda M; Cancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA., O'Malley ME; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15232, USA., Camacho CJ; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15232, USA., Delgoffe GM; Immunology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA., Chang Y; Cancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA. Electronic address: yc70@pitt.edu., Moore PS; Cancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA. Electronic address: psm9@pitt.edu.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Jun 15. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Wan+L%22">Wan L</searchLink>; Cancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA.<br /><searchLink fieldCode="AU" term="%22Xie+B%22">Xie B</searchLink>; Immunology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA.<br /><searchLink fieldCode="AU" term="%22Shuda+M%22">Shuda M</searchLink>; Cancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA.<br /><searchLink fieldCode="AU" term="%22O'Malley+ME%22">O'Malley ME</searchLink>; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15232, USA.<br /><searchLink fieldCode="AU" term="%22Camacho+CJ%22">Camacho CJ</searchLink>; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15232, USA.<br /><searchLink fieldCode="AU" term="%22Delgoffe+GM%22">Delgoffe GM</searchLink>; Immunology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA.<br /><searchLink fieldCode="AU" term="%22Chang+Y%22">Chang Y</searchLink>; Cancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA. Electronic address: yc70@pitt.edu.<br /><searchLink fieldCode="AU" term="%22Moore+PS%22">Moore PS</searchLink>; Cancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA. Electronic address: psm9@pitt.edu.
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  Data: <searchLink fieldCode="JN" term="%22100890581%22">Molecular therapy : the journal of the American Society of Gene Therapy</searchLink> [Mol Ther] 2026 Jun 15. <i>Date of Electronic Publication: </i>2026 Jun 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100890581 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1525-0024 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215250016%22">15250016 </searchLink><i>NLM ISO Abbreviation: </i>Mol Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ymthe.2026.06.027
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              Text: 2026 Jun 15
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