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Age-Dependent Remodeling of the Sciatic Nerve Proteome in 5xFAD Mice Can Be Attenuated by Exercise or Donepezil Treatment to Maintain Neuromuscular Function.

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Title: Age-Dependent Remodeling of the Sciatic Nerve Proteome in 5xFAD Mice Can Be Attenuated by Exercise or Donepezil Treatment to Maintain Neuromuscular Function.
Authors: Brisendine MH; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA., Nieves-Esparcia DQ; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA., Willoughby OS; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA., Brown B; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA., Brown JR; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA., Braxton DS; Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA., Henry SN; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA., McCoin CS; Department of Cellular Biology and Physiology and Department of Internal Medicine-Division of Endocrinology, University of Kansas Medical Center, Kansas City, Kansas, USA., Thyfault JP; Department of Cellular Biology and Physiology and Department of Internal Medicine-Division of Endocrinology, University of Kansas Medical Center, Kansas City, Kansas, USA.; Department of Neurology and KU Alzheimer's Disease Research Center, University of Kansas Medical Center, Kansas City, Kansas, USA., Morris JK; Department of Neurology and KU Alzheimer's Disease Research Center, University of Kansas Medical Center, Kansas City, Kansas, USA., Poelzing S; Translational Biology, Medicine, and Health Program, Virginia Polytechnic Institute and State University, Roanoke, Virginia, USA., Grange RW; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA., Jarome TJ; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.; School of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA., Najt CP; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.; Metabolism Core, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA., Drake JC; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.; Metabolism Core, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
Source: Aging cell [Aging Cell] 2026 Jun; Vol. 25 (6), pp. e70595.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Age-Dependent Remodeling of the Sciatic Nerve Proteome in 5xFAD Mice Can Be Attenuated by Exercise or Donepezil Treatment to Maintain Neuromuscular Function.
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