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Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial.

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Title: Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial.
Authors: Rozemeijer S; Department of Anesthesiology, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands. s.rozemeijer@amsterdamumc.nl.; Department of Intensive Care Medicine, Amsterdam Cardiovascular Science (ACS), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands. s.rozemeijer@amsterdamumc.nl., Dubois EA; Department of Intensive Care, Erasmus MC, Rotterdam, The Netherlands.; Department of Cardiology, Cardiovascular Institute, Rotterdam, The Netherlands., de Grooth HJ; Department of Intensive Care Medicine, Amsterdam Cardiovascular Science (ACS), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.; Intensive Care Center, University Medical Center Utrecht, Utrecht, The Netherlands., den Uil CA; Department of Intensive Care, Erasmus MC, Rotterdam, The Netherlands.; Department of Intensive Care Medicine, Maasstad Hospital, Rotterdam, The Netherlands., Rettig TCD; Department of Anesthesiology, Intensive Care and Pain Medicine, Amphia Hospital, Breda, The Netherlands., Rijpstra TA; Department of Anesthesiology, Intensive Care and Pain Medicine, Amphia Hospital, Breda, The Netherlands., van den Bogaard B; Department of Intensive Care Medicine, OLVG, Amsterdam, The Netherlands., van Zanten ARH; Department of Intensive Care Medicine, Gelderse Vallei Hospital, Ede, The Netherlands.; Division of Human Nutrition and Health, Wageningen University & Research, HELIX (Building 124), Wageningen, The Netherlands., Bosman RJ; Department of Intensive Care Medicine, OLVG, Amsterdam, The Netherlands., Elbers PWG; Department of Intensive Care Medicine, Amsterdam Medical Data Science (AMDS), Amsterdam Public Health (APH), Amsterdam Cardiovascular Science (ACS), Amsterdam Institute for Infection and Immunity (AI&I), Amsterdam UMC, University of Amsterdam, Vrije Universiteit, Amsterdam, The Netherlands., Girbes ARJ; Department of Intensive Care Medicine, Amsterdam Cardiovascular Science (ACS), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands., Vlaar APJ; Department of Intensive Care Medicine, Amsterdam Cardiovascular Science (ACS), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands., Twisk JWR; Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, The Netherlands., Christopher KB; Division of Renal Medicine, Brigham and Women's Hospital, Boston, USA., Schober P; Department of Anesthesiology, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands., Oudemans-van Straaten HM; Department of Intensive Care Medicine, Amsterdam Cardiovascular Science (ACS), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands., de Man AME; Department of Intensive Care Medicine, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands. ame.deman@amsterdamumc.nl.
Source: Intensive care medicine [Intensive Care Med] 2026 Jul; Vol. 52 (7), pp. 1447-1457. Date of Electronic Publication: 2026 Jun 16.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase II
Journal Info: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7704851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1238 (Electronic) Linking ISSN: 03424642 NLM ISO Abbreviation: Intensive Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Rozemeijer+S%22">Rozemeijer S</searchLink>; Department of Anesthesiology, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands. s.rozemeijer@amsterdamumc.nl.; Department of Intensive Care Medicine, Amsterdam Cardiovascular Science (ACS), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands. s.rozemeijer@amsterdamumc.nl.<br /><searchLink fieldCode="AU" term="%22Dubois+EA%22">Dubois EA</searchLink>; Department of Intensive Care, Erasmus MC, Rotterdam, The Netherlands.; Department of Cardiology, Cardiovascular Institute, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Grooth+HJ%22">de Grooth HJ</searchLink>; Department of Intensive Care Medicine, Amsterdam Cardiovascular Science (ACS), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.; Intensive Care Center, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22den+Uil+CA%22">den Uil CA</searchLink>; Department of Intensive Care, Erasmus MC, Rotterdam, The Netherlands.; Department of Intensive Care Medicine, Maasstad Hospital, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rettig+TCD%22">Rettig TCD</searchLink>; Department of Anesthesiology, Intensive Care and Pain Medicine, Amphia Hospital, Breda, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rijpstra+TA%22">Rijpstra TA</searchLink>; Department of Anesthesiology, Intensive Care and Pain Medicine, Amphia Hospital, Breda, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Bogaard+B%22">van den Bogaard B</searchLink>; Department of Intensive Care Medicine, OLVG, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Zanten+ARH%22">van Zanten ARH</searchLink>; Department of Intensive Care Medicine, Gelderse Vallei Hospital, Ede, The Netherlands.; Division of Human Nutrition and Health, Wageningen University & Research, HELIX (Building 124), Wageningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bosman+RJ%22">Bosman RJ</searchLink>; Department of Intensive Care Medicine, OLVG, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Elbers+PWG%22">Elbers PWG</searchLink>; Department of Intensive Care Medicine, Amsterdam Medical Data Science (AMDS), Amsterdam Public Health (APH), Amsterdam Cardiovascular Science (ACS), Amsterdam Institute for Infection and Immunity (AI&I), Amsterdam UMC, University of Amsterdam, Vrije Universiteit, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Girbes+ARJ%22">Girbes ARJ</searchLink>; Department of Intensive Care Medicine, Amsterdam Cardiovascular Science (ACS), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vlaar+APJ%22">Vlaar APJ</searchLink>; Department of Intensive Care Medicine, Amsterdam Cardiovascular Science (ACS), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Twisk+JWR%22">Twisk JWR</searchLink>; Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Christopher+KB%22">Christopher KB</searchLink>; Division of Renal Medicine, Brigham and Women's Hospital, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Schober+P%22">Schober P</searchLink>; Department of Anesthesiology, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Oudemans-van+Straaten+HM%22">Oudemans-van Straaten HM</searchLink>; Department of Intensive Care Medicine, Amsterdam Cardiovascular Science (ACS), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Man+AME%22">de Man AME</searchLink>; Department of Intensive Care Medicine, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam Medical Data Science (AMDS), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands. ame.deman@amsterdamumc.nl.
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  Data: <searchLink fieldCode="JN" term="%227704851%22">Intensive care medicine</searchLink> [Intensive Care Med] 2026 Jul; Vol. 52 (7), pp. 1447-1457. <i>Date of Electronic Publication: </i>2026 Jun 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7704851 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-1238 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203424642%22">03424642 </searchLink><i>NLM ISO Abbreviation: </i>Intensive Care Med <i>Subsets: </i>MEDLINE
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