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Current knowledge and challenges of sepsis-associated encephalopathy.

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Title: Current knowledge and challenges of sepsis-associated encephalopathy.
Authors: Shankar-Hari M; Centre for Critical Illness Research, School of Immunology and Microbial Sciences, King's College London, London, UK., Benghanem S; Medical Intensive Care Unit, Cochin Hospital, Assistance Publique-Hôpitaux de Paris-Centre (APHP-Centre), Paris, France.; Université Paris Cité, Institute of Psychiatry and Neurosciences of Paris (IPNP), INSERM U1266, Stroke Team, Paris, France., Bourhy L; Nervous System Development and Homeostasis Laboratory, The Francis Crick Institute, London, UK., Cunningham C; School of Biochemistry and Immunology Trinity Biomedical Sciences Institute, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland., Ehler J; Department of Anaesthesiology and Intensive Care Medicine, University Hospital Jena, Jena, Germany., Girard TD; Center for Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) in the Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, USA., Gofton TE; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Canada., Hermann B; Université Paris Cité, Institute of Psychiatry and Neurosciences of Paris (IPNP), INSERM U1266, Stroke Team, Paris, France.; Medical ICU, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris (AP-HP), Centre-Université Paris Cité, Paris, France., Jiwaji Z; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH16 4SB, UK., Mazeraud A; Université Paris Cité, Institute of Psychiatry and Neurosciences of Paris (IPNP), INSERM U1266, Stroke Team, Paris, France.; Neuro-Anesthesiology and Intensive Care Medicine, Anesthesia and Intensive Care Department GHU Paris Psychiatrie et Neurosciences, Pole Neuro, Sainte‑Anne Hospital, Paris, France., Needham E; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Rosa RG; Serviço de Medicina Interna, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil.; Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Singer M; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK., Slooter AJC; Department of Psychiatry, and Research School of Behavioural and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Intensive Care Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Department of Neurology, UZ Brussel and Vrije Universiteit Brussel, Brussels, Belgium., Sonneville R; Université Paris Cité, IAME, INSERM U1137, 75018, Paris, France.; APHP.Nord, Médecine Intensive Réanimation, Hôpital Bichat-Claude Bernard, Paris, France., Stevens RD; Departments of Anesthesiology and Critical Care Medicine, Neurology, Biomedical Engineering, Johns Hopkins University, Baltimore, USA., Taccone FS; Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Brussels, Belgium., Sharshar T; Université Paris Cité, Institute of Psychiatry and Neurosciences of Paris (IPNP), INSERM U1266, Stroke Team, Paris, France. t.sharshar@ghu-paris.fr.; Neuro-Anesthesiology and Intensive Care Medicine, Anesthesia and Intensive Care Department GHU Paris Psychiatrie et Neurosciences, Pole Neuro, Sainte‑Anne Hospital, Paris, France. t.sharshar@ghu-paris.fr.
Source: Intensive care medicine [Intensive Care Med] 2026 Jun 16. Date of Electronic Publication: 2026 Jun 16.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7704851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1238 (Electronic) Linking ISSN: 03424642 NLM ISO Abbreviation: Intensive Care Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Shankar-Hari+M%22">Shankar-Hari M</searchLink>; Centre for Critical Illness Research, School of Immunology and Microbial Sciences, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Benghanem+S%22">Benghanem S</searchLink>; Medical Intensive Care Unit, Cochin Hospital, Assistance Publique-Hôpitaux de Paris-Centre (APHP-Centre), Paris, France.; Université Paris Cité, Institute of Psychiatry and Neurosciences of Paris (IPNP), INSERM U1266, Stroke Team, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bourhy+L%22">Bourhy L</searchLink>; Nervous System Development and Homeostasis Laboratory, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Cunningham+C%22">Cunningham C</searchLink>; School of Biochemistry and Immunology Trinity Biomedical Sciences Institute, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Ehler+J%22">Ehler J</searchLink>; Department of Anaesthesiology and Intensive Care Medicine, University Hospital Jena, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Girard+TD%22">Girard TD</searchLink>; Center for Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) in the Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Gofton+TE%22">Gofton TE</searchLink>; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Canada.<br /><searchLink fieldCode="AU" term="%22Hermann+B%22">Hermann B</searchLink>; Université Paris Cité, Institute of Psychiatry and Neurosciences of Paris (IPNP), INSERM U1266, Stroke Team, Paris, France.; Medical ICU, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris (AP-HP), Centre-Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Jiwaji+Z%22">Jiwaji Z</searchLink>; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH16 4SB, UK.<br /><searchLink fieldCode="AU" term="%22Mazeraud+A%22">Mazeraud A</searchLink>; Université Paris Cité, Institute of Psychiatry and Neurosciences of Paris (IPNP), INSERM U1266, Stroke Team, Paris, France.; Neuro-Anesthesiology and Intensive Care Medicine, Anesthesia and Intensive Care Department GHU Paris Psychiatrie et Neurosciences, Pole Neuro, Sainte‑Anne Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Needham+E%22">Needham E</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Rosa+RG%22">Rosa RG</searchLink>; Serviço de Medicina Interna, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil.; Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Singer+M%22">Singer M</searchLink>; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Slooter+AJC%22">Slooter AJC</searchLink>; Department of Psychiatry, and Research School of Behavioural and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Intensive Care Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Department of Neurology, UZ Brussel and Vrije Universiteit Brussel, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Sonneville+R%22">Sonneville R</searchLink>; Université Paris Cité, IAME, INSERM U1137, 75018, Paris, France.; APHP.Nord, Médecine Intensive Réanimation, Hôpital Bichat-Claude Bernard, Paris, France.<br /><searchLink fieldCode="AU" term="%22Stevens+RD%22">Stevens RD</searchLink>; Departments of Anesthesiology and Critical Care Medicine, Neurology, Biomedical Engineering, Johns Hopkins University, Baltimore, USA.<br /><searchLink fieldCode="AU" term="%22Taccone+FS%22">Taccone FS</searchLink>; Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Sharshar+T%22">Sharshar T</searchLink>; Université Paris Cité, Institute of Psychiatry and Neurosciences of Paris (IPNP), INSERM U1266, Stroke Team, Paris, France. t.sharshar@ghu-paris.fr.; Neuro-Anesthesiology and Intensive Care Medicine, Anesthesia and Intensive Care Department GHU Paris Psychiatrie et Neurosciences, Pole Neuro, Sainte‑Anne Hospital, Paris, France. t.sharshar@ghu-paris.fr.
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