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IRX3 depletion promotes early cardiac commitment of hiPSC-Derived Cardiomyocytes.

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Title: IRX3 depletion promotes early cardiac commitment of hiPSC-Derived Cardiomyocytes.
Authors: Ribeiro Kalthof A; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil., Ferreira ND; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil., Silva CM; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil., Cordeiro Valadão I; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil., Pinheiro de Sousa I; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, United Kingdom., Bertoldi ERM; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil., Lima VM; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil., Turaca LT; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil., Barbosa ABRA; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil., Fonseca-Alaniz MH; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil., Concordet JP; Laboratoire Structure et Instabilité des Génomes, Inserm U1154, CNRS UMR7196, Muséum National d'Histoire Naturelle, Paris, France., Neri EA; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil., Krieger JE; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Source: PloS one [PLoS One] 2026 Jun 16; Vol. 21 (6), pp. e0351704. Date of Electronic Publication: 2026 Jun 16 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: IRX3 depletion promotes early cardiac commitment of hiPSC-Derived Cardiomyocytes.
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  Data: <searchLink fieldCode="AU" term="%22Ribeiro+Kalthof+A%22">Ribeiro Kalthof A</searchLink>; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Ferreira+ND%22">Ferreira ND</searchLink>; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Silva+CM%22">Silva CM</searchLink>; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Cordeiro+Valadão+I%22">Cordeiro Valadão I</searchLink>; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Pinheiro+de+Sousa+I%22">Pinheiro de Sousa I</searchLink>; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bertoldi+ERM%22">Bertoldi ERM</searchLink>; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Lima+VM%22">Lima VM</searchLink>; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Turaca+LT%22">Turaca LT</searchLink>; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Barbosa+ABRA%22">Barbosa ABRA</searchLink>; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Fonseca-Alaniz+MH%22">Fonseca-Alaniz MH</searchLink>; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Concordet+JP%22">Concordet JP</searchLink>; Laboratoire Structure et Instabilité des Génomes, Inserm U1154, CNRS UMR7196, Muséum National d'Histoire Naturelle, Paris, France.<br /><searchLink fieldCode="AU" term="%22Neri+EA%22">Neri EA</searchLink>; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Krieger+JE%22">Krieger JE</searchLink>; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
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