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Power and sample-size estimation in human microbiome research.

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Title: Power and sample-size estimation in human microbiome research.
Authors: Zhou Q; Department of Periodontics, Shanghai Stomatological Hospital, Center on Phenomics and Precision Medicine, Intelligent Medicine Institute, Fudan University, Shanghai 200433, China., Lu Y; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94035, USA., Wang L; Department of Health Informatics and Management, School of Health Humanities, Peking University, Beijing 100191, China., Zhou W; Department of Integrative Immunobiology, Duke University, Durham, NC 27705, USA., Oba H; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94035, USA., Zhou Y; Department of Medicine, UConn Health, Farmington, CT 06032, USA; The Jackson Laboratory for Genome Medicine, Farmington, CT 06032, USA., Shen M; Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, 900 N. Glebe Road, Arlington, VA 22203, USA., Qu X; Computer Science Department, George Washington University, Washington, DC 20052, USA., De Souza C; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94035, USA., Rayner A; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94035, USA; College of Computing, Data Science, and Society, UC Berkeley, Berkeley, CA 94720, USA., Chen Y; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, China-Singapore Belt and Road Joint Laboratory on Infection Research and Drug Development, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China., Cheng TY; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94035, USA., Ling Z; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, China-Singapore Belt and Road Joint Laboratory on Infection Research and Drug Development, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China., Li L; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, China-Singapore Belt and Road Joint Laboratory on Infection Research and Drug Development, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China., Liu C; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94035, USA., Voigt AY; Department of Dermatology, Duke University School of Medicine, Durham, NC 27710, USA., Xiong R; Department of Integrative Immunobiology, Duke University, Durham, NC 27705, USA., Oh J; Department of Integrative Immunobiology, Duke University, Durham, NC 27705, USA; Department of Dermatology, Duke University School of Medicine, Durham, NC 27710, USA., Spakowicz D; Division of Medical Oncology, Ohio State University Wexner Medical Center, James Cancer Hospital and Solove Research Institute, Columbus, OH 43210, USA., Dravillas C; Division of Medical Oncology, Ohio State University Wexner Medical Center, James Cancer Hospital and Solove Research Institute, Columbus, OH 43210, USA., Tian AW; Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University School of Medicine, Stanford, CA 94035, USA; Veteran Affairs Palo Alto Health Care System, Palo Alto, CA 94035, USA., Nicolls MR; Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University School of Medicine, Stanford, CA 94035, USA; Veteran Affairs Palo Alto Health Care System, Palo Alto, CA 94035, USA., Huynh AT; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94035, USA., Chen X; Institute for Immunity, Transplantation, and Infection, Stanford University, Stanford, CA 94035, USA., Hu J; Division of Biostatistics, Department of Population Health, New York University School of Medicine, New York, NY 10003, USA., He M; PolyU-Stanford Joint Research Centre for Longitudinal Deep Omics (JCRLDO), The Kong Kong Polytechnic University, Kowloon, Hong Kong SAR 999077, China., He F; State Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Research Unit of Proteomics Driven Cancer Precision Medicine(Chinese Academy of Medical Sciences), Beijing 102206, China; International Academy of Phronesis Medicine (Guangdong), Guangzhou 510000, China., Snyder MP; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94035, USA., Yang J; State Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Research Unit of Proteomics Driven Cancer Precision Medicine(Chinese Academy of Medical Sciences), Beijing 102206, China; International Academy of Phronesis Medicine (Guangdong), Guangzhou 510000, China; Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong 510005, China. Electronic address: yang_jing@gzlab.ac.cn., Zhou X; Department of Periodontics, Shanghai Stomatological Hospital, Center on Phenomics and Precision Medicine, Intelligent Medicine Institute, Fudan University, Shanghai 200433, China; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94035, USA; PolyU-Stanford Joint Research Centre for Longitudinal Deep Omics (JCRLDO), The Kong Kong Polytechnic University, Kowloon, Hong Kong SAR 999077, China. Electronic address: xin_zhou@fudan.edu.cn.
Source: Med (New York, N.Y.) [Med] 2026 Jul 10; Vol. 7 (7), pp. 101174. Date of Electronic Publication: 2026 Jun 16.
Publication Type: Journal Article; Review
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101769215 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-6340 (Electronic) Linking ISSN: 26666340 NLM ISO Abbreviation: Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Zhou+Q%22">Zhou Q</searchLink>; Department of Periodontics, Shanghai Stomatological Hospital, Center on Phenomics and Precision Medicine, Intelligent Medicine Institute, Fudan University, Shanghai 200433, China.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94035, USA.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Health Informatics and Management, School of Health Humanities, Peking University, Beijing 100191, China.<br /><searchLink fieldCode="AU" term="%22Zhou+W%22">Zhou W</searchLink>; Department of Integrative Immunobiology, Duke University, Durham, NC 27705, USA.<br /><searchLink fieldCode="AU" term="%22Oba+H%22">Oba H</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94035, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Department of Medicine, UConn Health, Farmington, CT 06032, USA; The Jackson Laboratory for Genome Medicine, Farmington, CT 06032, USA.<br /><searchLink fieldCode="AU" term="%22Shen+M%22">Shen M</searchLink>; Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, 900 N. 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Department of Genetics, Stanford University School of Medicine, Stanford, CA 94035, USA.<br /><searchLink fieldCode="AU" term="%22Voigt+AY%22">Voigt AY</searchLink>; Department of Dermatology, Duke University School of Medicine, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Xiong+R%22">Xiong R</searchLink>; Department of Integrative Immunobiology, Duke University, Durham, NC 27705, USA.<br /><searchLink fieldCode="AU" term="%22Oh+J%22">Oh J</searchLink>; Department of Integrative Immunobiology, Duke University, Durham, NC 27705, USA; Department of Dermatology, Duke University School of Medicine, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Spakowicz+D%22">Spakowicz D</searchLink>; Division of Medical Oncology, Ohio State University Wexner Medical Center, James Cancer Hospital and Solove Research Institute, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Dravillas+C%22">Dravillas C</searchLink>; Division of Medical Oncology, Ohio State University Wexner Medical Center, James Cancer Hospital and Solove Research Institute, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Tian+AW%22">Tian AW</searchLink>; Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University School of Medicine, Stanford, CA 94035, USA; Veteran Affairs Palo Alto Health Care System, Palo Alto, CA 94035, USA.<br /><searchLink fieldCode="AU" term="%22Nicolls+MR%22">Nicolls MR</searchLink>; Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University School of Medicine, Stanford, CA 94035, USA; Veteran Affairs Palo Alto Health Care System, Palo Alto, CA 94035, USA.<br /><searchLink fieldCode="AU" term="%22Huynh+AT%22">Huynh AT</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94035, USA.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Institute for Immunity, Transplantation, and Infection, Stanford University, Stanford, CA 94035, USA.<br /><searchLink fieldCode="AU" term="%22Hu+J%22">Hu J</searchLink>; Division of Biostatistics, Department of Population Health, New York University School of Medicine, New York, NY 10003, USA.<br /><searchLink fieldCode="AU" term="%22He+M%22">He M</searchLink>; PolyU-Stanford Joint Research Centre for Longitudinal Deep Omics (JCRLDO), The Kong Kong Polytechnic University, Kowloon, Hong Kong SAR 999077, China.<br /><searchLink fieldCode="AU" term="%22He+F%22">He F</searchLink>; State Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Research Unit of Proteomics Driven Cancer Precision Medicine(Chinese Academy of Medical Sciences), Beijing 102206, China; International Academy of Phronesis Medicine (Guangdong), Guangzhou 510000, China.<br /><searchLink fieldCode="AU" term="%22Snyder+MP%22">Snyder MP</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94035, USA.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; State Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Research Unit of Proteomics Driven Cancer Precision Medicine(Chinese Academy of Medical Sciences), Beijing 102206, China; International Academy of Phronesis Medicine (Guangdong), Guangzhou 510000, China; Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong 510005, China. Electronic address: yang_jing@gzlab.ac.cn.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Department of Periodontics, Shanghai Stomatological Hospital, Center on Phenomics and Precision Medicine, Intelligent Medicine Institute, Fudan University, Shanghai 200433, China; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94035, USA; PolyU-Stanford Joint Research Centre for Longitudinal Deep Omics (JCRLDO), The Kong Kong Polytechnic University, Kowloon, Hong Kong SAR 999077, China. Electronic address: xin_zhou@fudan.edu.cn.
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