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Abrupt discontinuation and tapering of antipsychotics in older adults with dementia: a target trial emulation study.

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Title: Abrupt discontinuation and tapering of antipsychotics in older adults with dementia: a target trial emulation study.
Authors: Hopkinson OK; Research Department of Practice and Policy, School of Pharmacy, University College London, London, UK., Chobanov J; Research Department of Practice and Policy, School of Pharmacy, University College London, London, UK., Goordeen D; Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia., Man KKC; Research Department of Practice and Policy, School of Pharmacy, University College London, London, UK; Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, London, UK; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Laboratory of Data Discovery for Health (D(2)4H), Hong Kong Special Administrative Region, China., Wong ICK; Research Department of Practice and Policy, School of Pharmacy, University College London, London, UK; Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, London, UK; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Laboratory of Data Discovery for Health (D(2)4H), Hong Kong Special Administrative Region, China; School of Pharmacy, Aston University, Birmingham, UK., Reeve E; Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia; School of Pharmacy and Biomedical Science, Adelaide University, Adelaide, SA, Australia., Bell JS; Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia., Wei L; Research Department of Practice and Policy, School of Pharmacy, University College London, London, UK; Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, London, UK., Howard R; Division of Psychiatry, University College London, London, UK., Lau WCY; Research Department of Practice and Policy, School of Pharmacy, University College London, London, UK; Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, London, UK; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Laboratory of Data Discovery for Health (D(2)4H), Hong Kong Special Administrative Region, China. Electronic address: wallis.lau@ucl.ac.uk.
Source: The lancet. Healthy longevity [Lancet Healthy Longev] 2026 May; Vol. 7 (5), pp. 100852.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101773309 Publication Model: Print Cited Medium: Internet ISSN: 2666-7568 (Electronic) Linking ISSN: 26667568 NLM ISO Abbreviation: Lancet Healthy Longev Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Hopkinson+OK%22">Hopkinson OK</searchLink>; Research Department of Practice and Policy, School of Pharmacy, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Chobanov+J%22">Chobanov J</searchLink>; Research Department of Practice and Policy, School of Pharmacy, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Goordeen+D%22">Goordeen D</searchLink>; Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Man+KKC%22">Man KKC</searchLink>; Research Department of Practice and Policy, School of Pharmacy, University College London, London, UK; Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, London, UK; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Laboratory of Data Discovery for Health (D(2)4H), Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Wong+ICK%22">Wong ICK</searchLink>; Research Department of Practice and Policy, School of Pharmacy, University College London, London, UK; Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, London, UK; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Laboratory of Data Discovery for Health (D(2)4H), Hong Kong Special Administrative Region, China; School of Pharmacy, Aston University, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Reeve+E%22">Reeve E</searchLink>; Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia; School of Pharmacy and Biomedical Science, Adelaide University, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Bell+JS%22">Bell JS</searchLink>; Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Wei+L%22">Wei L</searchLink>; Research Department of Practice and Policy, School of Pharmacy, University College London, London, UK; Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Howard+R%22">Howard R</searchLink>; Division of Psychiatry, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Lau+WCY%22">Lau WCY</searchLink>; Research Department of Practice and Policy, School of Pharmacy, University College London, London, UK; Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, London, UK; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Laboratory of Data Discovery for Health (D(2)4H), Hong Kong Special Administrative Region, China. Electronic address: wallis.lau@ucl.ac.uk.
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        Value: 10.1016/j.lanhl.2026.100852
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              Text: 2026 May
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