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Fibroblastic aspartoacylase suppresses TGFβ-mediated responses and cancer progression.

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Title: Fibroblastic aspartoacylase suppresses TGFβ-mediated responses and cancer progression.
Authors: Astobiza I; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain., Capó-Serra C; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Cantabria, Santander, Spain., Viera C; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain., Rodríguez J; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Cantabria, Santander, Spain., Carnicero P; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Cantabria, Santander, Spain., Juliá M; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Cantabria, Santander, Spain., Martinez A; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain., Pérez-López C; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Cantabria, Santander, Spain., Subijana M; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Cantabria, Santander, Spain., Ortiz-Sanz C; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain., Garcia-Longarte S; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain., Mendizabal I; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.; Traslational Prostate Cancer Research lab, CIC bioGUNE-Basurto, Biobizkaia Health Research Institute, Bilbao, Spain., Kay EJ; CRUK Scotland Institute, Glasgow, UK., Riera-Domingo C; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium., Rivis S; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium., Carlevaris O; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain., Egia-Mendikute L; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain., Cascais S; Department of Pathology, Fundação Champalimaud, Lisboa, Portugal., Martín-Martín N; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain.; Traslational Prostate Cancer Research lab, CIC bioGUNE-Basurto, Biobizkaia Health Research Institute, Bilbao, Spain., Fernandez-Ruiz S; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain., Torrano V; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain.; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao, Spain., Crespo JR; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain., Pujana-Vaquerizo M; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain., Espinet E; Department of Pathology and Experimental Therapy, School of Medicine, University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, Spain.; Molecular Mechanisms and Experimental Therapy in Oncology Program (Oncobell), Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain., Trumpp A; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Eiro N; Research Unit, Fundación Hospital de Jove, Avda. Eduardo Castro, Gijón, Spain., Vizoso FJ; Research Unit, Fundación Hospital de Jove, Avda. Eduardo Castro, Gijón, Spain., Vivancos A; Vall d Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Campus Hospital, Institució Catalana de Recerca i Estudis Avançats (ICREA), Universitat Autònoma de Barcelona (UAB), CIBERONC, Barcelona, Spain., Seoane J; Vall d Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Campus Hospital, Institució Catalana de Recerca i Estudis Avançats (ICREA), Universitat Autònoma de Barcelona (UAB), CIBERONC, Barcelona, Spain., Gonzalo D; Traslational Prostate Cancer Research lab, CIC bioGUNE-Basurto, Biobizkaia Health Research Institute, Bilbao, Spain.; Department of Urology, Basurto University Hospital, Bilbao, Spain., Rey S; Department of Urology, Basurto University Hospital, Bilbao, Spain., Santos-Martin A; Department of Urology, Basurto University Hospital, Bilbao, Spain., Ugalde-Olano A; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain.; Traslational Prostate Cancer Research lab, CIC bioGUNE-Basurto, Biobizkaia Health Research Institute, Bilbao, Spain.; Department of Pathology, Basurto University Hospital, Bilbao, Spain., Manini C; Department of Pathology, San Giovanni Bosco Hospital, Turin, Italy.; Department of Sciences of Public Health and Pediatrics, University of Turin, Turin, Italy., Lopez JI; Biobizkaia Health Research Institute, Barakaldo, Spain.; Department of Pathology of Cruces University Hospital, Barakaldo, Spain., Cabrera D; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain., Van Liempd SM; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain., Falcon-Perez JM; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.; Centro de Investigación Biomédica En Red de enfermedades hepáticas y digestivas (CIBEREHD), Madrid, Spain., Gomis RR; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain.; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology 08028, Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain., Palazon A; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain., Frezza C; Faculty of Medicine and University Hospital Cologne, Faculty of Mathematics and Natural Sciences, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany., Castillo-Martin M; Department of Pathology, Fundação Champalimaud, Lisboa, Portugal., Zanivan S; CRUK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK.; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Mazzone M; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium., Unda M; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain.; Traslational Prostate Cancer Research lab, CIC bioGUNE-Basurto, Biobizkaia Health Research Institute, Bilbao, Spain.; Department of Urology, Basurto University Hospital, Bilbao, Spain., Loizaga-Iriarte A; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain.; Traslational Prostate Cancer Research lab, CIC bioGUNE-Basurto, Biobizkaia Health Research Institute, Bilbao, Spain.; Department of Urology, Basurto University Hospital, Bilbao, Spain., Carracedo A; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain. acarracedo@cicbiogune.es.; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain. acarracedo@cicbiogune.es.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain. acarracedo@cicbiogune.es.; Traslational Prostate Cancer Research lab, CIC bioGUNE-Basurto, Biobizkaia Health Research Institute, Bilbao, Spain. acarracedo@cicbiogune.es.; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao, Spain. acarracedo@cicbiogune.es., Calvo F; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Cantabria, Santander, Spain. calvof@unican.es.
Source: Nature communications [Nat Commun] 2026 Jun 16; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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Items – Name: Title
  Label: Title
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  Data: Fibroblastic aspartoacylase suppresses TGFβ-mediated responses and cancer progression.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Astobiza+I%22">Astobiza I</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Capó-Serra+C%22">Capó-Serra C</searchLink>; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Cantabria, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Viera+C%22">Viera C</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez+J%22">Rodríguez J</searchLink>; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Cantabria, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Carnicero+P%22">Carnicero P</searchLink>; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Cantabria, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Juliá+M%22">Juliá M</searchLink>; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Cantabria, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Martinez+A%22">Martinez A</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Pérez-López+C%22">Pérez-López C</searchLink>; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Cantabria, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Subijana+M%22">Subijana M</searchLink>; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Cantabria, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Ortiz-Sanz+C%22">Ortiz-Sanz C</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Garcia-Longarte+S%22">Garcia-Longarte S</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Mendizabal+I%22">Mendizabal I</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.; Traslational Prostate Cancer Research lab, CIC bioGUNE-Basurto, Biobizkaia Health Research Institute, Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Kay+EJ%22">Kay EJ</searchLink>; CRUK Scotland Institute, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Riera-Domingo+C%22">Riera-Domingo C</searchLink>; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Rivis+S%22">Rivis S</searchLink>; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Carlevaris+O%22">Carlevaris O</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Egia-Mendikute+L%22">Egia-Mendikute L</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Cascais+S%22">Cascais S</searchLink>; Department of Pathology, Fundação Champalimaud, Lisboa, Portugal.<br /><searchLink fieldCode="AU" term="%22Martín-Martín+N%22">Martín-Martín N</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain.; Traslational Prostate Cancer Research lab, CIC bioGUNE-Basurto, Biobizkaia Health Research Institute, Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Fernandez-Ruiz+S%22">Fernandez-Ruiz S</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Torrano+V%22">Torrano V</searchLink>; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain.; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Crespo+JR%22">Crespo JR</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Pujana-Vaquerizo+M%22">Pujana-Vaquerizo M</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Espinet+E%22">Espinet E</searchLink>; Department of Pathology and Experimental Therapy, School of Medicine, University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, Spain.; Molecular Mechanisms and Experimental Therapy in Oncology Program (Oncobell), Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Trumpp+A%22">Trumpp A</searchLink>; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Eiro+N%22">Eiro N</searchLink>; Research Unit, Fundación Hospital de Jove, Avda. Eduardo Castro, Gijón, Spain.<br /><searchLink fieldCode="AU" term="%22Vizoso+FJ%22">Vizoso FJ</searchLink>; Research Unit, Fundación Hospital de Jove, Avda. Eduardo Castro, Gijón, Spain.<br /><searchLink fieldCode="AU" term="%22Vivancos+A%22">Vivancos A</searchLink>; Vall d Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Campus Hospital, Institució Catalana de Recerca i Estudis Avançats (ICREA), Universitat Autònoma de Barcelona (UAB), CIBERONC, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Seoane+J%22">Seoane J</searchLink>; Vall d Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Campus Hospital, Institució Catalana de Recerca i Estudis Avançats (ICREA), Universitat Autònoma de Barcelona (UAB), CIBERONC, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Gonzalo+D%22">Gonzalo D</searchLink>; Traslational Prostate Cancer Research lab, CIC bioGUNE-Basurto, Biobizkaia Health Research Institute, Bilbao, Spain.; Department of Urology, Basurto University Hospital, Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Rey+S%22">Rey S</searchLink>; Department of Urology, Basurto University Hospital, Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Santos-Martin+A%22">Santos-Martin A</searchLink>; Department of Urology, Basurto University Hospital, Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Ugalde-Olano+A%22">Ugalde-Olano A</searchLink>; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain.; Traslational Prostate Cancer Research lab, CIC bioGUNE-Basurto, Biobizkaia Health Research Institute, Bilbao, Spain.; Department of Pathology, Basurto University Hospital, Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Manini+C%22">Manini C</searchLink>; Department of Pathology, San Giovanni Bosco Hospital, Turin, Italy.; Department of Sciences of Public Health and Pediatrics, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Lopez+JI%22">Lopez JI</searchLink>; Biobizkaia Health Research Institute, Barakaldo, Spain.; Department of Pathology of Cruces University Hospital, Barakaldo, Spain.<br /><searchLink fieldCode="AU" term="%22Cabrera+D%22">Cabrera D</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Van+Liempd+SM%22">Van Liempd SM</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Falcon-Perez+JM%22">Falcon-Perez JM</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.; Centro de Investigación Biomédica En Red de enfermedades hepáticas y digestivas (CIBEREHD), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Gomis+RR%22">Gomis RR</searchLink>; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain.; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology 08028, Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Palazon+A%22">Palazon A</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Frezza+C%22">Frezza C</searchLink>; Faculty of Medicine and University Hospital Cologne, Faculty of Mathematics and Natural Sciences, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Castillo-Martin+M%22">Castillo-Martin M</searchLink>; Department of Pathology, Fundação Champalimaud, Lisboa, Portugal.<br /><searchLink fieldCode="AU" term="%22Zanivan+S%22">Zanivan S</searchLink>; CRUK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK.; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Mazzone+M%22">Mazzone M</searchLink>; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Unda+M%22">Unda M</searchLink>; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain.; Traslational Prostate Cancer Research lab, CIC bioGUNE-Basurto, Biobizkaia Health Research Institute, Bilbao, Spain.; Department of Urology, Basurto University Hospital, Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Loizaga-Iriarte+A%22">Loizaga-Iriarte A</searchLink>; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain.; Traslational Prostate Cancer Research lab, CIC bioGUNE-Basurto, Biobizkaia Health Research Institute, Bilbao, Spain.; Department of Urology, Basurto University Hospital, Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Carracedo+A%22">Carracedo A</searchLink>; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain. acarracedo@cicbiogune.es.; Centro de Investigación Biomédica En Red de Cáncer (CIBERONC), Madrid, Spain. acarracedo@cicbiogune.es.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain. acarracedo@cicbiogune.es.; Traslational Prostate Cancer Research lab, CIC bioGUNE-Basurto, Biobizkaia Health Research Institute, Bilbao, Spain. acarracedo@cicbiogune.es.; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao, Spain. acarracedo@cicbiogune.es.<br /><searchLink fieldCode="AU" term="%22Calvo+F%22">Calvo F</searchLink>; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Cantabria, Santander, Spain. calvof@unican.es.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jun 16; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Jun 16.
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      – TitleFull: Fibroblastic aspartoacylase suppresses TGFβ-mediated responses and cancer progression.
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          Dates:
            – D: 16
              M: 06
              Text: 2026 Jun 16
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1