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A dual-antigen mRNA-lipid polyplex vaccine elicits durable multistage immunity and sterile protection against malaria in mice.

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Title: A dual-antigen mRNA-lipid polyplex vaccine elicits durable multistage immunity and sterile protection against malaria in mice.
Authors: Wang X; State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China. xxwang1@simm.ac.cn., Wang A; State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China., Huang W; State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China., Tian P; State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China., Cao L; State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China., Xiao B; State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China., Han J; State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China., Huang Z; State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China. zhhuang@simm.ac.cn., Jiang L; State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China. lbjiang@simm.ac.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Jun 16. Date of Electronic Publication: 2026 Jun 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A dual-antigen mRNA-lipid polyplex vaccine elicits durable multistage immunity and sterile protection against malaria in mice.
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  Data: <searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China. xxwang1@simm.ac.cn.<br /><searchLink fieldCode="AU" term="%22Wang+A%22">Wang A</searchLink>; State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Huang+W%22">Huang W</searchLink>; State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Tian+P%22">Tian P</searchLink>; State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Cao+L%22">Cao L</searchLink>; State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Xiao+B%22">Xiao B</searchLink>; State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Han+J%22">Han J</searchLink>; State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Huang+Z%22">Huang Z</searchLink>; State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China. zhhuang@simm.ac.cn.<br /><searchLink fieldCode="AU" term="%22Jiang+L%22">Jiang L</searchLink>; State Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China. lbjiang@simm.ac.cn.
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  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2026 Jun 16. <i>Date of Electronic Publication: </i>2026 Jun 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100956087 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-7254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216714083%22">16714083 </searchLink><i>NLM ISO Abbreviation: </i>Acta Pharmacol Sin <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41401-026-01850-5
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        Text: English
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              Text: 2026 Jun 16
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