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Human iPSC-derived neurons stimulated with IFNγ present HLA class I-restricted antigens to cytotoxic CD8+ T cells.

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Title: Human iPSC-derived neurons stimulated with IFNγ present HLA class I-restricted antigens to cytotoxic CD8+ T cells.
Authors: Clarkson BD; Translational Neuroimmunology Laboratory, Mayo Clinic, Guggenheim 1542C; 200 First St SW, Rochester, MN, 55905, USA.; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA., Pucci S; Translational Neuroimmunology Laboratory, Mayo Clinic, Guggenheim 1542C; 200 First St SW, Rochester, MN, 55905, USA., Overlee BL; Translational Neuroimmunology Laboratory, Mayo Clinic, Guggenheim 1542C; 200 First St SW, Rochester, MN, 55905, USA., Shrestha RB; Translational Neuroimmunology Laboratory, Mayo Clinic, Guggenheim 1542C; 200 First St SW, Rochester, MN, 55905, USA., Mangalaparthi KK; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Raja R; Department of Immunology, Mayo Clinic, Phoenix, AZ, USA., Shang P; Translational Neuroimmunology Laboratory, Mayo Clinic, Guggenheim 1542C; 200 First St SW, Rochester, MN, 55905, USA., Curtis M; Department of Immunology, Mayo Clinic, Phoenix, AZ, USA.; Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Phoenix, AZ, USA., Pandey A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Manipal Academy of Higher Education, Manipal, Karnataka, India.; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA., Howe CL; Translational Neuroimmunology Laboratory, Mayo Clinic, Guggenheim 1542C; 200 First St SW, Rochester, MN, 55905, USA. howe@mayo.edu.; Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA. howe@mayo.edu.; Division of Experimental Neurology, Mayo Clinic, Rochester, MN, USA. howe@mayo.edu.; Department of Neurology, Mayo Clinic, Rochester, MN, USA. howe@mayo.edu.; Department of Immunology, Mayo Clinic, Rochester, MN, USA. howe@mayo.edu.
Source: Journal of neuroinflammation [J Neuroinflammation] 2026 Jun 17. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Human iPSC-derived neurons stimulated with IFNγ present HLA class I-restricted antigens to cytotoxic CD8<superscript>+</superscript> T cells.
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  Data: <searchLink fieldCode="AU" term="%22Clarkson+BD%22">Clarkson BD</searchLink>; Translational Neuroimmunology Laboratory, Mayo Clinic, Guggenheim 1542C; 200 First St SW, Rochester, MN, 55905, USA.; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Pucci+S%22">Pucci S</searchLink>; Translational Neuroimmunology Laboratory, Mayo Clinic, Guggenheim 1542C; 200 First St SW, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Overlee+BL%22">Overlee BL</searchLink>; Translational Neuroimmunology Laboratory, Mayo Clinic, Guggenheim 1542C; 200 First St SW, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Shrestha+RB%22">Shrestha RB</searchLink>; Translational Neuroimmunology Laboratory, Mayo Clinic, Guggenheim 1542C; 200 First St SW, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Mangalaparthi+KK%22">Mangalaparthi KK</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Raja+R%22">Raja R</searchLink>; Department of Immunology, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Shang+P%22">Shang P</searchLink>; Translational Neuroimmunology Laboratory, Mayo Clinic, Guggenheim 1542C; 200 First St SW, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Curtis+M%22">Curtis M</searchLink>; Department of Immunology, Mayo Clinic, Phoenix, AZ, USA.; Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Pandey+A%22">Pandey A</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Manipal Academy of Higher Education, Manipal, Karnataka, India.; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Howe+CL%22">Howe CL</searchLink>; Translational Neuroimmunology Laboratory, Mayo Clinic, Guggenheim 1542C; 200 First St SW, Rochester, MN, 55905, USA. howe@mayo.edu.; Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA. howe@mayo.edu.; Division of Experimental Neurology, Mayo Clinic, Rochester, MN, USA. howe@mayo.edu.; Department of Neurology, Mayo Clinic, Rochester, MN, USA. howe@mayo.edu.; Department of Immunology, Mayo Clinic, Rochester, MN, USA. howe@mayo.edu.
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  Data: <searchLink fieldCode="JN" term="%22101222974%22">Journal of neuroinflammation</searchLink> [J Neuroinflammation] 2026 Jun 17. <i>Date of Electronic Publication: </i>2026 Jun 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101222974 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1742-2094 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217422094%22">17422094 </searchLink><i>NLM ISO Abbreviation: </i>J Neuroinflammation <i>Subsets: </i>MEDLINE
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        Text: English
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              Text: 2026 Jun 17
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