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Early life social isolation stress and pain vulnerability: unraveling neuroimmune mechanisms and central sensitization.

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Title: Early life social isolation stress and pain vulnerability: unraveling neuroimmune mechanisms and central sensitization.
Authors: Belardo C; Department of Life Science, Health and Health Professions, Link Campus University, Rome, Italy.; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Trotta MC; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Ricciardi F; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Perrone M; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Morace AM; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Limongelli R; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Bonsale R; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., D'Agostino E; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Di Martino E; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Fusco A; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Natoli S; Department of Clinicial-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.; Pain Unit, Fondazione IRCSS Policlinico San Matteo, Pavia, Italy., Guida F; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Maione S; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Luongo L; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 Jun 01; Vol. 17, pp. 1844087. Date of Electronic Publication: 2026 Jun 01 (Print Publication: 2026).
Publication Type: Journal Article; Review
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Early life social isolation stress and pain vulnerability: unraveling neuroimmune mechanisms and central sensitization.
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  Data: <searchLink fieldCode="AU" term="%22Belardo+C%22">Belardo C</searchLink>; Department of Life Science, Health and Health Professions, Link Campus University, Rome, Italy.; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Trotta+MC%22">Trotta MC</searchLink>; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Ricciardi+F%22">Ricciardi F</searchLink>; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Perrone+M%22">Perrone M</searchLink>; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Morace+AM%22">Morace AM</searchLink>; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Limongelli+R%22">Limongelli R</searchLink>; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Bonsale+R%22">Bonsale R</searchLink>; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22D'Agostino+E%22">D'Agostino E</searchLink>; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Martino+E%22">Di Martino E</searchLink>; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Fusco+A%22">Fusco A</searchLink>; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Natoli+S%22">Natoli S</searchLink>; Department of Clinicial-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.; Pain Unit, Fondazione IRCSS Policlinico San Matteo, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Guida+F%22">Guida F</searchLink>; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Maione+S%22">Maione S</searchLink>; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Luongo+L%22">Luongo L</searchLink>; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101548923%22">Frontiers in pharmacology</searchLink> [Front Pharmacol] 2026 Jun 01; Vol. 17, pp. 1844087. <i>Date of Electronic Publication: </i>2026 Jun 01 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Media]%22">Frontiers Media] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101548923 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1663-9812 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216639812%22">16639812 </searchLink><i>NLM ISO Abbreviation: </i>Front Pharmacol <i>Subsets: </i>PubMed not MEDLINE
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