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Electroacupuncture alleviates myocardial ischemia-reperfusion injury by targeting and inhibiting NLRP3 inflammasome-mediated cardiomyocyte pyroptosis via serum exosomal miR-22-3p.

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Title: Electroacupuncture alleviates myocardial ischemia-reperfusion injury by targeting and inhibiting NLRP3 inflammasome-mediated cardiomyocyte pyroptosis via serum exosomal miR-22-3p.
Authors: Xiong J; College of Acupuncture, Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.; Sichuan Clinical Research Center for Acupuncture and Moxibustion Medicine, Chengdu, Sichuan, China.; Key Laboratory of Acupuncture and Moxibustion for Prevention and Treatment of Geriatric Diseases, Ministry of Education, Chengdu, Sichuan, China., Wei Y; College of Acupuncture, Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China., Liu Y; College of Acupuncture, Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China., Ling F; College of Acupuncture, Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China., Zhao Y; College of Acupuncture, Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China., Liu Y; College of Acupuncture, Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China., Sun Y; College of Acupuncture, Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China., Li D; College of Acupuncture, Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.; Sichuan Clinical Research Center for Acupuncture and Moxibustion Medicine, Chengdu, Sichuan, China.; Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China., Sun M; College of Acupuncture, Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.; Sichuan Clinical Research Center for Acupuncture and Moxibustion Medicine, Chengdu, Sichuan, China.; Key Laboratory of Acupuncture and Moxibustion for Prevention and Treatment of Geriatric Diseases, Ministry of Education, Chengdu, Sichuan, China., Cai D; College of Acupuncture, Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.; Sichuan Clinical Research Center for Acupuncture and Moxibustion Medicine, Chengdu, Sichuan, China.; Key Laboratory of Acupuncture and Moxibustion for Prevention and Treatment of Geriatric Diseases, Ministry of Education, Chengdu, Sichuan, China., Qi W; College of Acupuncture, Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.; Sichuan Clinical Research Center for Acupuncture and Moxibustion Medicine, Chengdu, Sichuan, China.; Key Laboratory of Acupuncture and Moxibustion for Prevention and Treatment of Geriatric Diseases, Ministry of Education, Chengdu, Sichuan, China., Zheng Q; College of Acupuncture, Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.; Sichuan Clinical Research Center for Acupuncture and Moxibustion Medicine, Chengdu, Sichuan, China.; Key Laboratory of Acupuncture and Moxibustion for Prevention and Treatment of Geriatric Diseases, Ministry of Education, Chengdu, Sichuan, China., Liang F; College of Acupuncture, Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.; Sichuan Clinical Research Center for Acupuncture and Moxibustion Medicine, Chengdu, Sichuan, China.; Key Laboratory of Acupuncture and Moxibustion for Prevention and Treatment of Geriatric Diseases, Ministry of Education, Chengdu, Sichuan, China.
Source: Frontiers in immunology [Front Immunol] 2026 Jun 01; Vol. 17, pp. 1824799. Date of Electronic Publication: 2026 Jun 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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        Value: 10.3389/fimmu.2026.1824799
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