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Non-ICANS neurotoxicity after BCMA-directed CAR-T therapy: Clinical spectrum, outcomes, and a framework for neurology-oncology co-management.

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Title: Non-ICANS neurotoxicity after BCMA-directed CAR-T therapy: Clinical spectrum, outcomes, and a framework for neurology-oncology co-management.
Authors: Werner JM; Department of Neurology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany., Gödel P; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany., Galldiks N; Department of Neurology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.; Institute of Neuroscience and Medicine (INM-3, INM-4) Research Center Juelich Juelich Germany., Krone C; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany., Schroeter M; Department of Neurology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany., Holtick U; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany., Flümann R; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany., Wunderlich G; Department of Neurology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.; Center for Rare Diseases, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany., Hallek M; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany., Fink GR; Department of Neurology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.; Institute of Neuroscience and Medicine (INM-3, INM-4) Research Center Juelich Juelich Germany., Scheid C; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany., Onur OA; Department of Neurology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany., Richardson T; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.
Source: HemaSphere [Hemasphere] 2026 Jun 15; Vol. 10 (6), pp. e70404. Date of Electronic Publication: 2026 Jun 15 (Print Publication: 2026).
Publication Type: Letter
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101740619 Publication Model: eCollection Cited Medium: Internet ISSN: 2572-9241 (Electronic) Linking ISSN: 25729241 NLM ISO Abbreviation: Hemasphere Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Non-ICANS neurotoxicity after BCMA-directed CAR-T therapy: Clinical spectrum, outcomes, and a framework for neurology-oncology co-management.
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  Data: <searchLink fieldCode="AU" term="%22Werner+JM%22">Werner JM</searchLink>; Department of Neurology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.<br /><searchLink fieldCode="AU" term="%22Gödel+P%22">Gödel P</searchLink>; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.<br /><searchLink fieldCode="AU" term="%22Galldiks+N%22">Galldiks N</searchLink>; Department of Neurology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.; Institute of Neuroscience and Medicine (INM-3, INM-4) Research Center Juelich Juelich Germany.<br /><searchLink fieldCode="AU" term="%22Krone+C%22">Krone C</searchLink>; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.<br /><searchLink fieldCode="AU" term="%22Schroeter+M%22">Schroeter M</searchLink>; Department of Neurology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.<br /><searchLink fieldCode="AU" term="%22Holtick+U%22">Holtick U</searchLink>; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.<br /><searchLink fieldCode="AU" term="%22Flümann+R%22">Flümann R</searchLink>; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.<br /><searchLink fieldCode="AU" term="%22Wunderlich+G%22">Wunderlich G</searchLink>; Department of Neurology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.; Center for Rare Diseases, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.<br /><searchLink fieldCode="AU" term="%22Hallek+M%22">Hallek M</searchLink>; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.<br /><searchLink fieldCode="AU" term="%22Fink+GR%22">Fink GR</searchLink>; Department of Neurology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.; Institute of Neuroscience and Medicine (INM-3, INM-4) Research Center Juelich Juelich Germany.<br /><searchLink fieldCode="AU" term="%22Scheid+C%22">Scheid C</searchLink>; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.<br /><searchLink fieldCode="AU" term="%22Onur+OA%22">Onur OA</searchLink>; Department of Neurology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.<br /><searchLink fieldCode="AU" term="%22Richardson+T%22">Richardson T</searchLink>; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany.
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