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Donor bone marrow together with recipient regulatory T cells induces chimerism without irradiation in kidney transplantation.

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Title: Donor bone marrow together with recipient regulatory T cells induces chimerism without irradiation in kidney transplantation.
Authors: Wekerle T; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Muckenhuber M; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Heinzel A; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria., Weijler AM; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., David AF; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria., Kainz V; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Hu K; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria., Mucha J; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Mengrelis K; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Reindl-Schwaighofer R; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria., Böhmig GA; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria., Watschinger B; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria., Györi G; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Soliman T; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Salat A; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Schwarz C; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Muhm M; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Heinze G; Institute of Clinical Biometrics, Center for Medical Data Science, Informatics, and Intelligent Systems, Medical University of Vienna, 1090 Vienna, Austria., Wolzt M; Clinical Trials Coordination Centre, Medical University of Vienna, 1090 Vienna, Austria., Worel N; Department of Transfusion Medicine and Cell Therapy, Medical University of Vienna, 1090 Vienna, Austria., Fortschegger M; St Anna Children's Cancer Research Institute, 1090 Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090 Vienna, Austria.; Labdia Labordiagnostik GmbH, 1090 Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, 1090 Vienna, Austria., Lion T; St Anna Children's Cancer Research Institute, 1090 Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090 Vienna, Austria.; Labdia Labordiagnostik GmbH, 1090 Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, 1090 Vienna, Austria., Regele H; Clinical Institute of Pathology, Medical University of Vienna, 1090 Vienna, Austria., Berlakovich G; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria., Halloran PF; Division of Nephrology and Immunology, University of Alberta, Edmonton, AB T6G 2S2, Canada., Edinger M; University Hospital Regensburg, Department of Internal Medicine III, José Carreras Centrum for Somatic Cell Therapy, Leibniz Institute of Immunotherapy, 93053 Regensburg, Germany., Oberbauer R; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria.
Source: Science translational medicine [Sci Transl Med] 2026 Jun 17; Vol. 18 (854), pp. eaee6850. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Donor bone marrow together with recipient regulatory T cells induces chimerism without irradiation in kidney transplantation.
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  Data: <searchLink fieldCode="AU" term="%22Wekerle+T%22">Wekerle T</searchLink>; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Muckenhuber+M%22">Muckenhuber M</searchLink>; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Heinzel+A%22">Heinzel A</searchLink>; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Weijler+AM%22">Weijler AM</searchLink>; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22David+AF%22">David AF</searchLink>; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Kainz+V%22">Kainz V</searchLink>; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Hu+K%22">Hu K</searchLink>; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Mucha+J%22">Mucha J</searchLink>; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Mengrelis+K%22">Mengrelis K</searchLink>; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Reindl-Schwaighofer+R%22">Reindl-Schwaighofer R</searchLink>; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Böhmig+GA%22">Böhmig GA</searchLink>; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Watschinger+B%22">Watschinger B</searchLink>; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Györi+G%22">Györi G</searchLink>; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Soliman+T%22">Soliman T</searchLink>; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Salat+A%22">Salat A</searchLink>; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Schwarz+C%22">Schwarz C</searchLink>; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Muhm+M%22">Muhm M</searchLink>; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Heinze+G%22">Heinze G</searchLink>; Institute of Clinical Biometrics, Center for Medical Data Science, Informatics, and Intelligent Systems, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Wolzt+M%22">Wolzt M</searchLink>; Clinical Trials Coordination Centre, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Worel+N%22">Worel N</searchLink>; Department of Transfusion Medicine and Cell Therapy, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Fortschegger+M%22">Fortschegger M</searchLink>; St Anna Children's Cancer Research Institute, 1090 Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090 Vienna, Austria.; Labdia Labordiagnostik GmbH, 1090 Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Lion+T%22">Lion T</searchLink>; St Anna Children's Cancer Research Institute, 1090 Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090 Vienna, Austria.; Labdia Labordiagnostik GmbH, 1090 Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Regele+H%22">Regele H</searchLink>; Clinical Institute of Pathology, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Berlakovich+G%22">Berlakovich G</searchLink>; Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Halloran+PF%22">Halloran PF</searchLink>; Division of Nephrology and Immunology, University of Alberta, Edmonton, AB T6G 2S2, Canada.<br /><searchLink fieldCode="AU" term="%22Edinger+M%22">Edinger M</searchLink>; University Hospital Regensburg, Department of Internal Medicine III, José Carreras Centrum for Somatic Cell Therapy, Leibniz Institute of Immunotherapy, 93053 Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Oberbauer+R%22">Oberbauer R</searchLink>; Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2026 Jun 17; Vol. 18 (854), pp. eaee6850. <i>Date of Electronic Publication: </i>2026 Jun 17.
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