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Deep learning-enabled discovery of antibiotics effective against Neisseria gonorrhoeae.

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Title: Deep learning-enabled discovery of antibiotics effective against Neisseria gonorrhoeae.
Authors: Anahtar MN; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Departments of Pathology and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Valeri JA; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Modaresi SM; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Krishnan A; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Donghia NM; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA., Palace SG; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA., Zheng EJ; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.; Program in Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Gulati A; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA., Jorgenson A; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA., Junaid A; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA., Bandyopadhyay P; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Luttens A; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Suresh K; Harvard Medical School, Boston, MA 02115, USA., Edwards P; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Wong F; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Integrated Biosciences Inc., Redwood City, CA 94065, USA., Zhang Y; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Ritz D; Proteomics Core Facility, Biozentrum, University of Basel, Basel CH-4056, Switzerland., Gaborieau M; Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden., Loh E; Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden.; Clinical Microbiology, Karolinska University Hospital, 171 76 Stockholm, Sweden., Gaetani M; Division of Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17 177 Stockholm, Sweden.; Chemical Proteomics Unit, Science for Life Laboratory (SciLifeLab), 171 77 Stockholm, Sweden., Aschtgen MS; Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden., Saei AA; Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden., Grad YH; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA., Ingber DE; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.; Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02539, USA., Collins JJ; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Source: Science translational medicine [Sci Transl Med] 2026 Jun 17; Vol. 18 (854), pp. eads4699. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Deep learning-enabled discovery of antibiotics effective against Neisseria gonorrhoeae.
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  Data: <searchLink fieldCode="AU" term="%22Anahtar+MN%22">Anahtar MN</searchLink>; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Departments of Pathology and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Valeri+JA%22">Valeri JA</searchLink>; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Modaresi+SM%22">Modaresi SM</searchLink>; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Krishnan+A%22">Krishnan A</searchLink>; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Donghia+NM%22">Donghia NM</searchLink>; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Palace+SG%22">Palace SG</searchLink>; Department of Immunology and Infectious Diseases, Harvard T. 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Chan School of Public Health, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+EJ%22">Zheng EJ</searchLink>; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.; Program in Chemical Biology, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Gulati+A%22">Gulati A</searchLink>; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Jorgenson+A%22">Jorgenson A</searchLink>; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Junaid+A%22">Junaid A</searchLink>; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Bandyopadhyay+P%22">Bandyopadhyay P</searchLink>; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Luttens+A%22">Luttens A</searchLink>; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Suresh+K%22">Suresh K</searchLink>; Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Edwards+P%22">Edwards P</searchLink>; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Wong+F%22">Wong F</searchLink>; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Integrated Biosciences Inc., Redwood City, CA 94065, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.; Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Ritz+D%22">Ritz D</searchLink>; Proteomics Core Facility, Biozentrum, University of Basel, Basel CH-4056, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gaborieau+M%22">Gaborieau M</searchLink>; Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Loh+E%22">Loh E</searchLink>; Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden.; Clinical Microbiology, Karolinska University Hospital, 171 76 Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Gaetani+M%22">Gaetani M</searchLink>; Division of Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17 177 Stockholm, Sweden.; Chemical Proteomics Unit, Science for Life Laboratory (SciLifeLab), 171 77 Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Aschtgen+MS%22">Aschtgen MS</searchLink>; Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Saei+AA%22">Saei AA</searchLink>; Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Grad+YH%22">Grad YH</searchLink>; Department of Immunology and Infectious Diseases, Harvard T. 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