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Multi-omics profiling identifies ACP2 as a lysosome-associated biomarker linked to immune dynamics and clinical outcomes in glioma.

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Title: Multi-omics profiling identifies ACP2 as a lysosome-associated biomarker linked to immune dynamics and clinical outcomes in glioma.
Authors: Palekkode N; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei 11031, Taiwan; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan; Department of Biotechnology, Mother Teresa Women's University, Kodaikanal, Tamil Nadu 624101, India., Liu CH; Department of Nursing, Ditmanson Medical Foundation Chia-Yi Christian Hospita, Chiayi City 600, Taiwan., Chen JB; Clinical Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City 60002, Taiwan., Solomon DD; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei 11031, Taiwan; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan; Yogananda School of AI Computers and Data Sciences, Shoolini University, Solan 173229, India., Kumar S; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei 11031, Taiwan; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan; Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Himachal Pradesh, India., Ko CC; Department of Medical Imaging, Chi-Mei Medical Center, Tainan 710402, Taiwan; Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan; School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan., Yen MC; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan., Yeh IJ; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan., Xuan DTM; Faculty of Pharmacy, Van Lang University, 69/68 Dang Thuy Tram Street, Binh Loi Trung Ward, Ho Chi Minh City 70000, Viet Nam., Lin HY; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei 11031, Taiwan; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan; Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University, Taipei 11031, Taiwan; Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA., Fathima A; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei 11031, Taiwan; Computer Engineering with specialization in Artificial Intelligence and Machine Learning, Presidency University, Yelahanka, Bengaluru 560064, India., Lee YK; School of Medicine, National Defense Medical University, Taipei 11490, Taiwan; Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan; Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei 11490, Taiwan; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan., Chang KF; Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan; Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei 11490, Taiwan., Lin HR; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan; Nursing Department, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan., Wang CY; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei 11031, Taiwan; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan. Electronic address: chihyang@tmu.edu.tw., Shih CL; Clinical Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City 60002, Taiwan., Nguyen NUN; Center for Regenerative Medicine, University of South Florida Health Heart Institute, Tampa, FL 33602, USA; Division of Cardiology, Department of Internal Medicine, Morsani School of Medicine, University of South Florida, Tampa, FL 33602, USA.
Source: Computational biology and chemistry [Comput Biol Chem] 2026 Jun 07; Vol. 124 (Pt 2), pp. 109165. Date of Electronic Publication: 2026 Jun 07.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101157394 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-928X (Electronic) Linking ISSN: 14769271 NLM ISO Abbreviation: Comput Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multi-omics profiling identifies ACP2 as a lysosome-associated biomarker linked to immune dynamics and clinical outcomes in glioma.
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  Data: <searchLink fieldCode="AU" term="%22Palekkode+N%22">Palekkode N</searchLink>; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei 11031, Taiwan; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan; Department of Biotechnology, Mother Teresa Women's University, Kodaikanal, Tamil Nadu 624101, India.<br /><searchLink fieldCode="AU" term="%22Liu+CH%22">Liu CH</searchLink>; Department of Nursing, Ditmanson Medical Foundation Chia-Yi Christian Hospita, Chiayi City 600, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+JB%22">Chen JB</searchLink>; Clinical Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City 60002, Taiwan.<br /><searchLink fieldCode="AU" term="%22Solomon+DD%22">Solomon DD</searchLink>; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei 11031, Taiwan; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan; Yogananda School of AI Computers and Data Sciences, Shoolini University, Solan 173229, India.<br /><searchLink fieldCode="AU" term="%22Kumar+S%22">Kumar S</searchLink>; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei 11031, Taiwan; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan; Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Himachal Pradesh, India.<br /><searchLink fieldCode="AU" term="%22Ko+CC%22">Ko CC</searchLink>; Department of Medical Imaging, Chi-Mei Medical Center, Tainan 710402, Taiwan; Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan; School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yen+MC%22">Yen MC</searchLink>; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+IJ%22">Yeh IJ</searchLink>; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.<br /><searchLink fieldCode="AU" term="%22Xuan+DTM%22">Xuan DTM</searchLink>; Faculty of Pharmacy, Van Lang University, 69/68 Dang Thuy Tram Street, Binh Loi Trung Ward, Ho Chi Minh City 70000, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Lin+HY%22">Lin HY</searchLink>; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei 11031, Taiwan; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan; Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University, Taipei 11031, Taiwan; Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA.<br /><searchLink fieldCode="AU" term="%22Fathima+A%22">Fathima A</searchLink>; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei 11031, Taiwan; Computer Engineering with specialization in Artificial Intelligence and Machine Learning, Presidency University, Yelahanka, Bengaluru 560064, India.<br /><searchLink fieldCode="AU" term="%22Lee+YK%22">Lee YK</searchLink>; School of Medicine, National Defense Medical University, Taipei 11490, Taiwan; Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan; Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei 11490, Taiwan; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+KF%22">Chang KF</searchLink>; Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan; Division of Experimental Surgery Center, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei 11490, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+HR%22">Lin HR</searchLink>; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan; Nursing Department, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+CY%22">Wang CY</searchLink>; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei 11031, Taiwan; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan. Electronic address: chihyang@tmu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Shih+CL%22">Shih CL</searchLink>; Clinical Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City 60002, Taiwan.<br /><searchLink fieldCode="AU" term="%22Nguyen+NUN%22">Nguyen NUN</searchLink>; Center for Regenerative Medicine, University of South Florida Health Heart Institute, Tampa, FL 33602, USA; Division of Cardiology, Department of Internal Medicine, Morsani School of Medicine, University of South Florida, Tampa, FL 33602, USA.
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  Data: <searchLink fieldCode="JN" term="%22101157394%22">Computational biology and chemistry</searchLink> [Comput Biol Chem] 2026 Jun 07; Vol. 124 (Pt 2), pp. 109165. <i>Date of Electronic Publication: </i>2026 Jun 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101157394 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-928X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214769271%22">14769271 </searchLink><i>NLM ISO Abbreviation: </i>Comput Biol Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.compbiolchem.2026.109165
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        Text: English
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              Text: 2026 Jun 07
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