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HydrOcortisone and fludRocortisoNe for critical ILLness-related corticosteroid insufficiency (HORNbILL): study protocol for a multicentre randomised placebo-controlled trial.

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Title: HydrOcortisone and fludRocortisoNe for critical ILLness-related corticosteroid insufficiency (HORNbILL): study protocol for a multicentre randomised placebo-controlled trial.
Authors: Heming N; Department of Intensive Care, APHP University Versailles Saint Quentin-University Paris Saclay, Hopital Raymond-Poincare, Garches, France nicholas.heming@aphp.fr.; Institut Hospitalo Universitaire IHU-3 SEPSIS Institute, Garches, France.; Laboratory of Infection & Inflammation-U1173, School of Medicine, INSERM, University Versailles Saint Quentin-University Paris Saclay, Garches, France., Baron E; Sorbonne University, GRC 29, AP-HP, DMU DREAM, Department of Anaesthesiology and Critical Care, Pitié-Salpêtrière Hospital, Paris, France., Muller G; Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire (CHU) d'Orléans, Orleans, France.; LI²RSO, Université d'Orléans, Château de la Source, Orléans, France., Badie J; Service de Médecine Intensive Réanimation, Hôpital Nord Franche-Comté - Site de Belfort, Belfort, France., Preau S; U1167 - RID-AGE - Facteurs de Risque Et Déterminants Moléculaires Des Maladies Liées Au Vieillissement, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.; Division of Intensive Care, Hôpital Roger Salengro, CHU de Lille, Lille, France., Siami S; General Intensive Care Unit, Sud Essonne Hospital, Etampes, France., Pouplet C; Médecine Intensive-Réanimation, District Hospital Center, La Roche-sur-Yon, France., Berger A; Médecine Intensive-Réanimation, CH de Haguenau, Haguenau, France., Damoisel C; Service de Réanimation Polyvalente et Surveillance Continue, Assistance Publique-Hôpitaux de Paris, Université Paris Saclay, Hôpital Antoine Béclère, Clamart, France., Argaud L; Service de Médecine Intensive Réanimation, HCL de Lyon, Hôpital Edouard Herriot, Lyon, France., Rigaud JP; Service de Réanimation, CH de Dieppe, Dieppe, France., Lambiotte F; Service de Réanimation Polyvalente, Centre Hospitalier de Valenciennes, Valenciennes, France., Klouche K; Service Médecine Intensive et Réanimation, CHU de Montpellier, Montpellier, France., Bruel C; Service de Réanimation Polyvalente, Groupe hospitalier Paris Saint-Joseph, Paris, France., Clere-Jehl R; Medical Intensive Care Unit, Strasbourg University Nouvel Hôpital Civil, Strasbourg, France., Darmon M; Medical Intensive Care Unit Department, AP-HP, Saint-Louis University Hospital, Paris-Cité University, Paris, France.; INSERM UMR1342, Institut de Recherche Saint-Louis, Paris, France., Maizel J; Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, France., Quenot JP; Service de Médecine Intensive-Réanimation, Université Bourgogne-Europe, CHU Dijon-Bourgogne, Dijon, France.; Centre d'Investigation Clinique, module épidémiologie clinique, INSERM, CIC 1432, Université Bourgogne Europe, CHU Dijon Bourgogne, Dijon, France.; Equipe Lipness UMR 1231, 21, Université Bourgogne-Europe, CHU Dijon-Bourgogne, Dijon, France., Robin C; Agence générale des équipements et produits de santé, Assistance Publique Hôpitaux de Paris, Paris, France., Fleuriet J; Institut Hospitalo Universitaire IHU-3 SEPSIS Institute, Garches, France., Jacota M; Paris Saclay Ouest Clinical Research Unit, Ambroise Paré Hospital, AP-HP, Boulogne-Billancourt, France., Paoletti X; Université Versailles St Quentin and INSERM U1331 STAMPM, Institut Curie, Paris, France., Annane D; Department of Intensive Care, APHP University Versailles Saint Quentin-University Paris Saclay, Hopital Raymond-Poincare, Garches, France.; Institut Hospitalo Universitaire IHU-3 SEPSIS Institute, Garches, France.; Laboratory of Infection & Inflammation-U1173, School of Medicine, INSERM, University Versailles Saint Quentin-University Paris Saclay, Garches, France.
Corporate Authors: HORNBILL consortium, CRICS-TRIGGERSEP network
Source: BMJ open [BMJ Open] 2026 Jun 17; Vol. 16 (6), pp. e119187. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: HydrOcortisone and fludRocortisoNe for critical ILLness-related corticosteroid insufficiency (HORNbILL): study protocol for a multicentre randomised placebo-controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Heming+N%22">Heming N</searchLink>; Department of Intensive Care, APHP University Versailles Saint Quentin-University Paris Saclay, Hopital Raymond-Poincare, Garches, France nicholas.heming@aphp.fr.; Institut Hospitalo Universitaire IHU-3 SEPSIS Institute, Garches, France.; Laboratory of Infection & Inflammation-U1173, School of Medicine, INSERM, University Versailles Saint Quentin-University Paris Saclay, Garches, France.<br /><searchLink fieldCode="AU" term="%22Baron+E%22">Baron E</searchLink>; Sorbonne University, GRC 29, AP-HP, DMU DREAM, Department of Anaesthesiology and Critical Care, Pitié-Salpêtrière Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Muller+G%22">Muller G</searchLink>; Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire (CHU) d'Orléans, Orleans, France.; LI²RSO, Université d'Orléans, Château de la Source, Orléans, France.<br /><searchLink fieldCode="AU" term="%22Badie+J%22">Badie J</searchLink>; Service de Médecine Intensive Réanimation, Hôpital Nord Franche-Comté - Site de Belfort, Belfort, France.<br /><searchLink fieldCode="AU" term="%22Preau+S%22">Preau S</searchLink>; U1167 - RID-AGE - Facteurs de Risque Et Déterminants Moléculaires Des Maladies Liées Au Vieillissement, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.; Division of Intensive Care, Hôpital Roger Salengro, CHU de Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Siami+S%22">Siami S</searchLink>; General Intensive Care Unit, Sud Essonne Hospital, Etampes, France.<br /><searchLink fieldCode="AU" term="%22Pouplet+C%22">Pouplet C</searchLink>; Médecine Intensive-Réanimation, District Hospital Center, La Roche-sur-Yon, France.<br /><searchLink fieldCode="AU" term="%22Berger+A%22">Berger A</searchLink>; Médecine Intensive-Réanimation, CH de Haguenau, Haguenau, France.<br /><searchLink fieldCode="AU" term="%22Damoisel+C%22">Damoisel C</searchLink>; Service de Réanimation Polyvalente et Surveillance Continue, Assistance Publique-Hôpitaux de Paris, Université Paris Saclay, Hôpital Antoine Béclère, Clamart, France.<br /><searchLink fieldCode="AU" term="%22Argaud+L%22">Argaud L</searchLink>; Service de Médecine Intensive Réanimation, HCL de Lyon, Hôpital Edouard Herriot, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Rigaud+JP%22">Rigaud JP</searchLink>; Service de Réanimation, CH de Dieppe, Dieppe, France.<br /><searchLink fieldCode="AU" term="%22Lambiotte+F%22">Lambiotte F</searchLink>; Service de Réanimation Polyvalente, Centre Hospitalier de Valenciennes, Valenciennes, France.<br /><searchLink fieldCode="AU" term="%22Klouche+K%22">Klouche K</searchLink>; Service Médecine Intensive et Réanimation, CHU de Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Bruel+C%22">Bruel C</searchLink>; Service de Réanimation Polyvalente, Groupe hospitalier Paris Saint-Joseph, Paris, France.<br /><searchLink fieldCode="AU" term="%22Clere-Jehl+R%22">Clere-Jehl R</searchLink>; Medical Intensive Care Unit, Strasbourg University Nouvel Hôpital Civil, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Darmon+M%22">Darmon M</searchLink>; Medical Intensive Care Unit Department, AP-HP, Saint-Louis University Hospital, Paris-Cité University, Paris, France.; INSERM UMR1342, Institut de Recherche Saint-Louis, Paris, France.<br /><searchLink fieldCode="AU" term="%22Maizel+J%22">Maizel J</searchLink>; Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, France.<br /><searchLink fieldCode="AU" term="%22Quenot+JP%22">Quenot JP</searchLink>; Service de Médecine Intensive-Réanimation, Université Bourgogne-Europe, CHU Dijon-Bourgogne, Dijon, France.; Centre d'Investigation Clinique, module épidémiologie clinique, INSERM, CIC 1432, Université Bourgogne Europe, CHU Dijon Bourgogne, Dijon, France.; Equipe Lipness UMR 1231, 21, Université Bourgogne-Europe, CHU Dijon-Bourgogne, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Robin+C%22">Robin C</searchLink>; Agence générale des équipements et produits de santé, Assistance Publique Hôpitaux de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Fleuriet+J%22">Fleuriet J</searchLink>; Institut Hospitalo Universitaire IHU-3 SEPSIS Institute, Garches, France.<br /><searchLink fieldCode="AU" term="%22Jacota+M%22">Jacota M</searchLink>; Paris Saclay Ouest Clinical Research Unit, Ambroise Paré Hospital, AP-HP, Boulogne-Billancourt, France.<br /><searchLink fieldCode="AU" term="%22Paoletti+X%22">Paoletti X</searchLink>; Université Versailles St Quentin and INSERM U1331 STAMPM, Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Annane+D%22">Annane D</searchLink>; Department of Intensive Care, APHP University Versailles Saint Quentin-University Paris Saclay, Hopital Raymond-Poincare, Garches, France.; Institut Hospitalo Universitaire IHU-3 SEPSIS Institute, Garches, France.; Laboratory of Infection & Inflammation-U1173, School of Medicine, INSERM, University Versailles Saint Quentin-University Paris Saclay, Garches, France.
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