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White matter hyperintensities are associated with locus coeruleus atrophy and astrocytic β2-adrenergic receptor expression.

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Title: White matter hyperintensities are associated with locus coeruleus atrophy and astrocytic β2-adrenergic receptor expression.
Authors: Vidal V; Brain and Mind Centre, The University of Sydney, Sydney, Australia., Farías G; Departamento de Neurociencia Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Hospital Clínico de la Universidad de Chile, Santiago, Chile., Delgado C; Departamento de Neurociencia Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Hospital Clínico de la Universidad de Chile, Santiago, Chile., Delano PH; Departamento de Neurociencia Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Hospital Clínico de la Universidad de Chile, Santiago, Chile., Vergara RC; Departamento de Kinesiología, Universidad Metropolitana de Ciencias de la Educación, Santiago, Chile.; Centro Nacional de Inteligencia Artificial (CENIA), Santiago, Chile., Orellana P; Hospital Clínico de la Universidad de Chile, Santiago, Chile., Ossandón T; Departamento de Psiquiatría Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.; Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile., Crossley NA; Departamento de Psiquiatría Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile., Gonzalez-Campo C; Centro de Neurociencia Cognitiva, Universidad de San Andrés, Buenos Aires, Argentina., Naismith SL; Brain and Mind Centre, The University of Sydney, Sydney, Australia., Gonzalez-Gomez R; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile., Coronel-Oliveros C; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.; Global Brain Health Institute (GBHI), University of California, US, Trinity College Dublin, Dublin, Ireland., Ibáñez A; Centro de Neurociencia Cognitiva, Universidad de San Andrés, Buenos Aires, Argentina.; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.; Global Brain Health Institute (GBHI), University of California, US, Trinity College Dublin, Dublin, Ireland.; Department of Biophysics, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain., Wainstein G; Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile., Sanders RD; Brain and Mind Centre, The University of Sydney, Sydney, Australia., Shine JM; Brain and Mind Centre, The University of Sydney, Sydney, Australia., Medel V; Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Jun; Vol. 22 (6), pp. e71583.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: White matter hyperintensities are associated with locus coeruleus atrophy and astrocytic β<subscript>2</subscript>-adrenergic receptor expression.
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  Data: <searchLink fieldCode="AU" term="%22Vidal+V%22">Vidal V</searchLink>; Brain and Mind Centre, The University of Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Farías+G%22">Farías G</searchLink>; Departamento de Neurociencia Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Hospital Clínico de la Universidad de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Delgado+C%22">Delgado C</searchLink>; Departamento de Neurociencia Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Hospital Clínico de la Universidad de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Delano+PH%22">Delano PH</searchLink>; Departamento de Neurociencia Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Hospital Clínico de la Universidad de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Vergara+RC%22">Vergara RC</searchLink>; Departamento de Kinesiología, Universidad Metropolitana de Ciencias de la Educación, Santiago, Chile.; Centro Nacional de Inteligencia Artificial (CENIA), Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Orellana+P%22">Orellana P</searchLink>; Hospital Clínico de la Universidad de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Ossandón+T%22">Ossandón T</searchLink>; Departamento de Psiquiatría Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.; Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Crossley+NA%22">Crossley NA</searchLink>; Departamento de Psiquiatría Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Campo+C%22">Gonzalez-Campo C</searchLink>; Centro de Neurociencia Cognitiva, Universidad de San Andrés, Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Naismith+SL%22">Naismith SL</searchLink>; Brain and Mind Centre, The University of Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Gomez+R%22">Gonzalez-Gomez R</searchLink>; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Coronel-Oliveros+C%22">Coronel-Oliveros C</searchLink>; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.; Global Brain Health Institute (GBHI), University of California, US, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Ibáñez+A%22">Ibáñez A</searchLink>; Centro de Neurociencia Cognitiva, Universidad de San Andrés, Buenos Aires, Argentina.; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.; Global Brain Health Institute (GBHI), University of California, US, Trinity College Dublin, Dublin, Ireland.; Department of Biophysics, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Wainstein+G%22">Wainstein G</searchLink>; Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Sanders+RD%22">Sanders RD</searchLink>; Brain and Mind Centre, The University of Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Shine+JM%22">Shine JM</searchLink>; Brain and Mind Centre, The University of Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Medel+V%22">Medel V</searchLink>; Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2026 Jun; Vol. 22 (6), pp. e71583.
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        Value: 10.1002/alz.71583
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