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Engineering functional ventral midbrain dopaminergic neurons in human organoids through WNT modulation and bioreactor culture.

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Title: Engineering functional ventral midbrain dopaminergic neurons in human organoids through WNT modulation and bioreactor culture.
Authors: Raji H; Institut Imagine Paris - Inserm U1163, 24 boulevard du Montparnasse, 75015, Paris, France.; Université Paris Cité, 85 boulevard Saint-Germain, 75006, Paris, France.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Bertoli F; Institut Imagine Paris - Inserm U1163, 24 boulevard du Montparnasse, 75015, Paris, France.; Université Paris Cité, 85 boulevard Saint-Germain, 75006, Paris, France.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Perez MJ; Institut Imagine Paris - Inserm U1163, 24 boulevard du Montparnasse, 75015, Paris, France.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Lam A; Institut Imagine Paris - Inserm U1163, 24 boulevard du Montparnasse, 75015, Paris, France., Volpicelli-Daley L; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.; Killion Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, 1719 6th Ave South, Birmingham, AL, 35294, USA., Deleidi M; Institut Imagine Paris - Inserm U1163, 24 boulevard du Montparnasse, 75015, Paris, France. michela.deleidi@institutimagine.org.; Université Paris Cité, 85 boulevard Saint-Germain, 75006, Paris, France. michela.deleidi@institutimagine.org.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA. michela.deleidi@institutimagine.org.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Jun 17. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Engineering functional ventral midbrain dopaminergic neurons in human organoids through WNT modulation and bioreactor culture.
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  Data: <searchLink fieldCode="AU" term="%22Raji+H%22">Raji H</searchLink>; Institut Imagine Paris - Inserm U1163, 24 boulevard du Montparnasse, 75015, Paris, France.; Université Paris Cité, 85 boulevard Saint-Germain, 75006, Paris, France.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.<br /><searchLink fieldCode="AU" term="%22Bertoli+F%22">Bertoli F</searchLink>; Institut Imagine Paris - Inserm U1163, 24 boulevard du Montparnasse, 75015, Paris, France.; Université Paris Cité, 85 boulevard Saint-Germain, 75006, Paris, France.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.<br /><searchLink fieldCode="AU" term="%22Perez+MJ%22">Perez MJ</searchLink>; Institut Imagine Paris - Inserm U1163, 24 boulevard du Montparnasse, 75015, Paris, France.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.<br /><searchLink fieldCode="AU" term="%22Lam+A%22">Lam A</searchLink>; Institut Imagine Paris - Inserm U1163, 24 boulevard du Montparnasse, 75015, Paris, France.<br /><searchLink fieldCode="AU" term="%22Volpicelli-Daley+L%22">Volpicelli-Daley L</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.; Killion Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, 1719 6th Ave South, Birmingham, AL, 35294, USA.<br /><searchLink fieldCode="AU" term="%22Deleidi+M%22">Deleidi M</searchLink>; Institut Imagine Paris - Inserm U1163, 24 boulevard du Montparnasse, 75015, Paris, France. michela.deleidi@institutimagine.org.; Université Paris Cité, 85 boulevard Saint-Germain, 75006, Paris, France. michela.deleidi@institutimagine.org.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA. michela.deleidi@institutimagine.org.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group+Specialist+Journals%22">Nature Publishing Group Specialist Journals </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9607835 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5578 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213594184%22">13594184 </searchLink><i>NLM ISO Abbreviation: </i>Mol Psychiatry <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41380-026-03667-4
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              Text: 2026 Jun 17
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