IDH1-R132H enhances oncolytic HSV-1 therapy by facilitating viral entry and immune activation in glioma.

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Title: IDH1-R132H enhances oncolytic HSV-1 therapy by facilitating viral entry and immune activation in glioma.
Authors: Panagioti E; Harvey Cushing Neuro-oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. epanagio@bidmc.harvard.edu.; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. epanagio@bidmc.harvard.edu., Kelley HJ; Harvey Cushing Neuro-oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Ling AL; Harvey Cushing Neuro-oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sejour L; Department of Pathology, HMS Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Cancer Research Institute, Boston, MA, USA., Saini S; Harvey Cushing Neuro-oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Goins WF; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Roberts D; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Sotiriou S; Department of Pathology, Aristotle University of Thessaloniki, Thessaloniki, Greece., Bryan Iorgulescu J; Molecular Diagnostics Laboratory, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dixon KO; Gene Lay Institute for Immunology and Inflammation at Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA., Yaffe MB; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; David. H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, US.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Gynecology Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; Departments of Internal Medicine and Immunology, Moffitt Cancer Center, Tampa, FL, USA., Vlachos IS; Department of Pathology, HMS Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Cancer Research Institute, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Castro MG; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Lawler SE; Department of Pathology and Laboratory Medicine, Legorreta Cancer Center, Brown University, Providence, RI, USA., Freeman GJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Kuchroo VK; Gene Lay Institute for Immunology and Inflammation at Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA.; Center for Neurologic Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Antonio Chiocca E; Harvey Cushing Neuro-oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. eachiocca@mgb.org., Cook CH; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. chcook@bidmc.harvard.edu.
Source: Nature communications [Nat Commun] 2026 Jun 17. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-73974-5