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IDH1-R132H enhances oncolytic HSV-1 therapy by facilitating viral entry and immune activation in glioma.

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Title: IDH1-R132H enhances oncolytic HSV-1 therapy by facilitating viral entry and immune activation in glioma.
Authors: Panagioti E; Harvey Cushing Neuro-oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. epanagio@bidmc.harvard.edu.; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. epanagio@bidmc.harvard.edu., Kelley HJ; Harvey Cushing Neuro-oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Ling AL; Harvey Cushing Neuro-oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sejour L; Department of Pathology, HMS Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Cancer Research Institute, Boston, MA, USA., Saini S; Harvey Cushing Neuro-oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Goins WF; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Roberts D; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Sotiriou S; Department of Pathology, Aristotle University of Thessaloniki, Thessaloniki, Greece., Bryan Iorgulescu J; Molecular Diagnostics Laboratory, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dixon KO; Gene Lay Institute for Immunology and Inflammation at Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA., Yaffe MB; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; David. H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, US.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Gynecology Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; Departments of Internal Medicine and Immunology, Moffitt Cancer Center, Tampa, FL, USA., Vlachos IS; Department of Pathology, HMS Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Cancer Research Institute, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Castro MG; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Lawler SE; Department of Pathology and Laboratory Medicine, Legorreta Cancer Center, Brown University, Providence, RI, USA., Freeman GJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Kuchroo VK; Gene Lay Institute for Immunology and Inflammation at Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA.; Center for Neurologic Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Antonio Chiocca E; Harvey Cushing Neuro-oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. eachiocca@mgb.org., Cook CH; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. chcook@bidmc.harvard.edu.
Source: Nature communications [Nat Commun] 2026 Jun 17. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: IDH1-R132H enhances oncolytic HSV-1 therapy by facilitating viral entry and immune activation in glioma.
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  Data: <searchLink fieldCode="AU" term="%22Panagioti+E%22">Panagioti E</searchLink>; Harvey Cushing Neuro-oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. epanagio@bidmc.harvard.edu.; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. epanagio@bidmc.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Kelley+HJ%22">Kelley HJ</searchLink>; Harvey Cushing Neuro-oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ling+AL%22">Ling AL</searchLink>; Harvey Cushing Neuro-oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sejour+L%22">Sejour L</searchLink>; Department of Pathology, HMS Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Cancer Research Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Saini+S%22">Saini S</searchLink>; Harvey Cushing Neuro-oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Goins+WF%22">Goins WF</searchLink>; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+D%22">Roberts D</searchLink>; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sotiriou+S%22">Sotiriou S</searchLink>; Department of Pathology, Aristotle University of Thessaloniki, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Bryan+Iorgulescu+J%22">Bryan Iorgulescu J</searchLink>; Molecular Diagnostics Laboratory, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Dixon+KO%22">Dixon KO</searchLink>; Gene Lay Institute for Immunology and Inflammation at Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yaffe+MB%22">Yaffe MB</searchLink>; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; David. H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, US.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Gynecology Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; Departments of Internal Medicine and Immunology, Moffitt Cancer Center, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Vlachos+IS%22">Vlachos IS</searchLink>; Department of Pathology, HMS Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Cancer Research Institute, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Castro+MG%22">Castro MG</searchLink>; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Lawler+SE%22">Lawler SE</searchLink>; Department of Pathology and Laboratory Medicine, Legorreta Cancer Center, Brown University, Providence, RI, USA.<br /><searchLink fieldCode="AU" term="%22Freeman+GJ%22">Freeman GJ</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kuchroo+VK%22">Kuchroo VK</searchLink>; Gene Lay Institute for Immunology and Inflammation at Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA.; Center for Neurologic Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Antonio+Chiocca+E%22">Antonio Chiocca E</searchLink>; Harvey Cushing Neuro-oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. eachiocca@mgb.org.<br /><searchLink fieldCode="AU" term="%22Cook+CH%22">Cook CH</searchLink>; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. chcook@bidmc.harvard.edu.
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