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Citrus depressa peel extract and its polymethoxyflavones mitigate acetaminophen-induced chronic liver injury in mice through antioxidant activation, epigenetic regulation, and gut microbiota modulation.

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Title: Citrus depressa peel extract and its polymethoxyflavones mitigate acetaminophen-induced chronic liver injury in mice through antioxidant activation, epigenetic regulation, and gut microbiota modulation.
Authors: Tsai PY; Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan City, Taiwan., Lin ZH; Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan City, Taiwan., Wei GJ; Institute of Food Safety and Health Risk Assessment, National Yang Ming Chiao Tung University, Taipei City, Taiwan., Wu LY; Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan City, Taiwan., Wu TY; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei City, Taiwan., Tung YC; Department of Food Science, National Ilan University, Yilan County, Taiwan., Huang SH; Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan City, Taiwan., Su ZY; Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan City, Taiwan.
Source: Journal of the science of food and agriculture [J Sci Food Agric] 2026 Jun 17. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons Country of Publication: England NLM ID: 0376334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0010 (Electronic) Linking ISSN: 00225142 NLM ISO Abbreviation: J Sci Food Agric Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Citrus depressa peel extract and its polymethoxyflavones mitigate acetaminophen-induced chronic liver injury in mice through antioxidant activation, epigenetic regulation, and gut microbiota modulation.
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  Data: <searchLink fieldCode="AU" term="%22Tsai+PY%22">Tsai PY</searchLink>; Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+ZH%22">Lin ZH</searchLink>; Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wei+GJ%22">Wei GJ</searchLink>; Institute of Food Safety and Health Risk Assessment, National Yang Ming Chiao Tung University, Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+LY%22">Wu LY</searchLink>; Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+TY%22">Wu TY</searchLink>; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tung+YC%22">Tung YC</searchLink>; Department of Food Science, National Ilan University, Yilan County, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+SH%22">Huang SH</searchLink>; Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Su+ZY%22">Su ZY</searchLink>; Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan City, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%220376334%22">Journal of the science of food and agriculture</searchLink> [J Sci Food Agric] 2026 Jun 17. <i>Date of Electronic Publication: </i>2026 Jun 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%22">John Wiley & Sons </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0376334 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-0010 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200225142%22">00225142 </searchLink><i>NLM ISO Abbreviation: </i>J Sci Food Agric <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1002/jsfa.70785
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      – Code: eng
        Text: English
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      – TitleFull: Citrus depressa peel extract and its polymethoxyflavones mitigate acetaminophen-induced chronic liver injury in mice through antioxidant activation, epigenetic regulation, and gut microbiota modulation.
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            NameFull: Tsai PY
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            NameFull: Lin ZH
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            – D: 17
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              Text: 2026 Jun 17
              Type: published
              Y: 2026
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            – Type: issn-electronic
              Value: 1097-0010
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            – TitleFull: Journal of the science of food and agriculture
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