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Extracellular vesicles from steatotic hepatocytes promote endothelial dysfunction and atherogenesis via miR-30b-5p/ELOVL5 axis.

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Title: Extracellular vesicles from steatotic hepatocytes promote endothelial dysfunction and atherogenesis via miR-30b-5p/ELOVL5 axis.
Authors: Rhee M; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea., Lee J; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea., Jung CW; College of Pharmacy, Seoul National University, Seoul 08826, Korea., Yang J; Department of Biochemistry and Convergence Medical Science, Institute of Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, Korea., Choi WG; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea., You YH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea., Park HS; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea., Lee EY; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea., Lee EK; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea., Kwon SW; College of Pharmacy, Seoul National University, Seoul 08826, Korea., Kim YB; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA., Lee SH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. Electronic address: hwanx2@catholic.ac.kr.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Jun 17. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Extracellular vesicles from steatotic hepatocytes promote endothelial dysfunction and atherogenesis via miR-30b-5p/ELOVL5 axis.
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  Data: <searchLink fieldCode="AU" term="%22Rhee+M%22">Rhee M</searchLink>; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.<br /><searchLink fieldCode="AU" term="%22Jung+CW%22">Jung CW</searchLink>; College of Pharmacy, Seoul National University, Seoul 08826, Korea.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Department of Biochemistry and Convergence Medical Science, Institute of Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, Korea.<br /><searchLink fieldCode="AU" term="%22Choi+WG%22">Choi WG</searchLink>; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.<br /><searchLink fieldCode="AU" term="%22You+YH%22">You YH</searchLink>; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.<br /><searchLink fieldCode="AU" term="%22Park+HS%22">Park HS</searchLink>; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.<br /><searchLink fieldCode="AU" term="%22Lee+EY%22">Lee EY</searchLink>; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.<br /><searchLink fieldCode="AU" term="%22Lee+EK%22">Lee EK</searchLink>; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+SW%22">Kwon SW</searchLink>; College of Pharmacy, Seoul National University, Seoul 08826, Korea.<br /><searchLink fieldCode="AU" term="%22Kim+YB%22">Kim YB</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Lee+SH%22">Lee SH</searchLink>; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. Electronic address: hwanx2@catholic.ac.kr.
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        Value: 10.1016/j.ymthe.2026.06.031
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      – TitleFull: Extracellular vesicles from steatotic hepatocytes promote endothelial dysfunction and atherogenesis via miR-30b-5p/ELOVL5 axis.
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              Text: 2026 Jun 17
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