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Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells.

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Title: Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells.
Authors: Kim H; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center , New York, NY, USA.; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center , New York, NY, USA., Grassmann S; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center , New York, NY, USA., Wong W; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center , New York, NY, USA.; Tri-Institutional Training Program in Computational Biology and Medicine , New York, NY, USA., Adams NM; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center , New York, NY, USA., Kanno Y; Lymphocyte Cell Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA., O'Shea JJ; Lymphocyte Cell Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA., Leslie CS; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center , New York, NY, USA., Rogatsky I; Hospital for Special Surgery Research Institute, David Z. Rosensweig Genomics Center , New York, NY, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medical College , New York, NY, USA., Sun JC; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center , New York, NY, USA.; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center , New York, NY, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medical College , New York, NY, USA.
Source: The Journal of experimental medicine [J Exp Med] 2026 Aug 03; Vol. 223 (8). Date of Electronic Publication: 2026 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells.
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  Data: <searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center , New York, NY, USA.; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center , New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Grassmann+S%22">Grassmann S</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center , New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wong+W%22">Wong W</searchLink>; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center , New York, NY, USA.; Tri-Institutional Training Program in Computational Biology and Medicine , New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Adams+NM%22">Adams NM</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center , New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kanno+Y%22">Kanno Y</searchLink>; Lymphocyte Cell Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22O'Shea+JJ%22">O'Shea JJ</searchLink>; Lymphocyte Cell Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Leslie+CS%22">Leslie CS</searchLink>; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center , New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rogatsky+I%22">Rogatsky I</searchLink>; Hospital for Special Surgery Research Institute, David Z. Rosensweig Genomics Center , New York, NY, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medical College , New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sun+JC%22">Sun JC</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center , New York, NY, USA.; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center , New York, NY, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medical College , New York, NY, USA.
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  Data: <searchLink fieldCode="JN" term="%222985109R%22">The Journal of experimental medicine</searchLink> [J Exp Med] 2026 Aug 03; Vol. 223 (8). <i>Date of Electronic Publication: </i>2026 Jun 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Rockefeller+University+Press%22">Rockefeller University Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985109R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1540-9538 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200221007%22">00221007 </searchLink><i>NLM ISO Abbreviation: </i>J Exp Med <i>Subsets: </i>MEDLINE
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        Value: 10.1084/jem.20250995
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        Text: English
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              Text: 2026 Aug 03
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