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Ampyrone is a direct agonist of human tyrosinase and a potential therapeutic for hypopigmentation disorders.

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Title: Ampyrone is a direct agonist of human tyrosinase and a potential therapeutic for hypopigmentation disorders.
Authors: Dolinska MB; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America., Wang YA; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America., Coussens NP; National Center for Advancing Translational Sciences, NIH, Rockville, United States of America., Kalaskar VK; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America., Eraslan Z; Department of Dermatology, Weill Cornell School of Medicine, New York, United States of America., Grondin SJ; Department of Pharmacology, Weill Cornell School of Medicine, New York, United States of America., Bonica J; Department of Dermatology, Weill Cornell School of Medicine, New York, United States of America., Toay S; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America., Hall MD; National Center for Advancing Translational Sciences, NIH, Rockville, United States of America., Shen M; National Center for Advancing Translational Sciences, NIH, Rockville, United States of America., Boxer M; National Center for Advancing Translational Sciences, NIH, Rockville, United States of America., Chen Q; Department of Pharmacology, Weill Cornell School of Medicine, New York, United States of America., Gross SS; Department of Pharmacology, Weill Cornell School of Medicine, New York, United States of America., Attarwala N; Department of Pharmacology, Weill Cornell School of Medicine, New York, United States of America., Jittayasothorn Y; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America., Alur RP; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America., Shukla D; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America., Kee R; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America., DeYoung C; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America., Sha C; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America., Adams DR; National Human Genome Research Institute, NIH, Bethesda, United States of America., Loftus SK; National Human Genome Research Institute, NIH, Bethesda, United States of America., Cogliati T; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America., Sergeev YV; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America., Zippin JH; Department of Dermatology, Weill Cornell School of Medicine, New York, United States of America., Brooks BP; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America.
Source: JCI insight [JCI Insight] 2026 Jun 18. Date of Electronic Publication: 2026 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Ampyrone is a direct agonist of human tyrosinase and a potential therapeutic for hypopigmentation disorders.
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  Data: <searchLink fieldCode="AU" term="%22Dolinska+MB%22">Dolinska MB</searchLink>; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Wang+YA%22">Wang YA</searchLink>; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Coussens+NP%22">Coussens NP</searchLink>; National Center for Advancing Translational Sciences, NIH, Rockville, United States of America.<br /><searchLink fieldCode="AU" term="%22Kalaskar+VK%22">Kalaskar VK</searchLink>; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Eraslan+Z%22">Eraslan Z</searchLink>; Department of Dermatology, Weill Cornell School of Medicine, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Grondin+SJ%22">Grondin SJ</searchLink>; Department of Pharmacology, Weill Cornell School of Medicine, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Bonica+J%22">Bonica J</searchLink>; Department of Dermatology, Weill Cornell School of Medicine, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Toay+S%22">Toay S</searchLink>; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Hall+MD%22">Hall MD</searchLink>; National Center for Advancing Translational Sciences, NIH, Rockville, United States of America.<br /><searchLink fieldCode="AU" term="%22Shen+M%22">Shen M</searchLink>; National Center for Advancing Translational Sciences, NIH, Rockville, United States of America.<br /><searchLink fieldCode="AU" term="%22Boxer+M%22">Boxer M</searchLink>; National Center for Advancing Translational Sciences, NIH, Rockville, United States of America.<br /><searchLink fieldCode="AU" term="%22Chen+Q%22">Chen Q</searchLink>; Department of Pharmacology, Weill Cornell School of Medicine, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Gross+SS%22">Gross SS</searchLink>; Department of Pharmacology, Weill Cornell School of Medicine, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Attarwala+N%22">Attarwala N</searchLink>; Department of Pharmacology, Weill Cornell School of Medicine, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Jittayasothorn+Y%22">Jittayasothorn Y</searchLink>; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Alur+RP%22">Alur RP</searchLink>; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Shukla+D%22">Shukla D</searchLink>; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Kee+R%22">Kee R</searchLink>; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22DeYoung+C%22">DeYoung C</searchLink>; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Sha+C%22">Sha C</searchLink>; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Adams+DR%22">Adams DR</searchLink>; National Human Genome Research Institute, NIH, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Loftus+SK%22">Loftus SK</searchLink>; National Human Genome Research Institute, NIH, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Cogliati+T%22">Cogliati T</searchLink>; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Sergeev+YV%22">Sergeev YV</searchLink>; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America.<br /><searchLink fieldCode="AU" term="%22Zippin+JH%22">Zippin JH</searchLink>; Department of Dermatology, Weill Cornell School of Medicine, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Brooks+BP%22">Brooks BP</searchLink>; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, United States of America.
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        Text: English
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